Chemistry And Applications Of Benzimidazole And Its Derivatives
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| Author | : Maria Marinescu |
| Publisher | : BoD – Books on Demand |
| Total Pages | : 230 |
| Release | : 2019-10-02 |
| Genre | : Science |
| ISBN | : 1789845521 |
Finding new strategies for synthesizing benzimidazole derivatives and functionalizing the benzimidazole core has proved to be important due to the compound's various applications in medicine, chemistry, and other areas. The multitude of benzimidazole derivatives marketed as drugs has led to intensive research in the field for the discovery of new biologically active structures. The general applications of benzimidazole derivatives in materials chemistry, electronics, technology, dyes, pigments, and agriculture open up new research horizons. This book guides the rational design of benzimidazole derivatives synthesis with certain applications. Chapters cover such topics as therapeutic use of benzimidazole in conditions like diabetes, viruses, and parasitic diseases; X-ray crystal structure of selected benzimidazole derivatives; benzimidazole compounds for cancer therapy; and others.
| Author | : Aksel A. Vestergaard |
| Publisher | : |
| Total Pages | : 0 |
| Release | : 2020 |
| Genre | : Benzimidazoles |
| ISBN | : 9781536169867 |
Benzimidazole: Preparation and Applications first defines the structure, physical and chemical properties of the benzimidazole compound class. Further conventional and alternative synthesis methods and important reactions of these compound derivatives are illustrated with examples. The authors provide an overview of benzimidazole-based synthetic medicine and their significant applications in treating various ailments. The chemical reactions of benzimidazole with other heterocyclic compounds/chemical reagents produce a lot of new substituted molecules, which have potential pharmaceutical applications. A literature review is presented focusing on the synthesis of chiral compounds and their subsequent applications as therapeutic compounds in order to better evaluate the results so far. Additionally, the authors discuss how nenzimidazole derivatives play a vital role in organic light emitting diodes as emissive materials, host materials, electron transport materials, hole blocking materials, etc., and have pharmaceutical applications such as antimicrobial, antihypertensive, anti-HIV and anticancer. Following this, this collection examines classes of potential chemosensors possessing benzimidazole moieties which are capable of both visual and optical estimation of target analytes over a broad concentration range and without interference of contemporary analytes. Important methodologies used for the synthesis of variedly substituted benzimidazoles are presented along with their multi-target therapeutic uses. The latest research on anti-tumor and antimicrobial benzimidazole compounds, as well as structure-activity correlations, drug design, clinical and preclinical studies is also presented. Benzimidazole-based polymers with various architecture and copolymers are discussed with a variation of properties such as mechanical, thermal stability, thermo-oxidative stability and enhanced performance. The penultimate chapter covers a critical analysis of the recent developments in benzimidazole framework research and the future scope of benzimidazole framework in ligand designing. In closing, the synthesis and biological properties of coordination compounds containing benzimidazole derivatives are presented and discussed.
| Author | : Vakhid A. Mamedov |
| Publisher | : Springer |
| Total Pages | : 451 |
| Release | : 2016-04-26 |
| Genre | : Science |
| ISBN | : 3319297732 |
This book reviews the fundamental aspects of quinoxaline chemistry: synthesis, reactions, mechanisms, structure, properties, and uses. The first four chapters present a survey of the developments in quinoxaline chemistry since the publication of the monograph on “Condensed Pyrazines” by Cheeseman and Cookson in 1979. These chapters give comprehensive coverage of all the methods of the synthesis of quinoxalines and the important quinoxaline-containing ring systems such as thiazolo[3,4-a]-, pyrrolo[1,2-a]-, and imidazo[1,5-a]quinoxalines. Chapter five describes many new methods for the construction of quinoxaline macrocycles, which are important in applications such as optical devices and materials. The final chapter reviews all previously known rearrangements of heterocyclic systems that lead to benzimidazole derivatives. Mamedov critically analyses these transformations to reveal a novel acid-catalyzed rearrangement of quinoxalinones giving 2-heteroarylbenzimidazoles and 1-heteroarylbenzimidazolones in the presence of nucleophilic reactants (MAMEDOV Heterocycle Rearrangement). This book is of interest to researchers in the fields of heterocyclic and synthetic organic chemistry.
| Author | : Chandrabhan Verma |
| Publisher | : John Wiley & Sons |
| Total Pages | : 530 |
| Release | : 2021-12-02 |
| Genre | : Technology & Engineering |
| ISBN | : 111979448X |
Provides comprehensive coverage of organic corrosion inhibitors used in modern industrial platforms, including current developments in the design of promising classes of organic corrosion inhibitors Corrosion is the cause of significant economic and safety-related problems that span across industries and applications, including production and processing operations, transportation and public utilities infrastructure, and oil and gas exploration. The use of organic corrosion inhibitors is a simple and cost-effective method for protecting processes, machinery, and materials while remaining environmentally acceptable. Organic Corrosion Inhibitors: Synthesis, Characterization, Mechanism, and Applications provides up-to-date coverage of all aspects of organic corrosion inhibitors, including their fundamental characteristics, synthesis, characterization, inhibition mechanism, and industrial applications. Divided into five sections, the text first covers the basics of corrosion and prevention, experimental and computational testing, and the differences between organic and inorganic corrosion inhibitors. The next section describes various heterocyclic and non-heterocyclic corrosion inhibitors, followed by discussion of the corrosion inhibition characteristics of carbohydrates, amino acids, and other organic green corrosion inhibitors. The final two sections examine the corrosion inhibition properties of carbon nanotubes and graphene oxide, and review the application of natural and synthetic polymers as corrosion inhibitors. Featuring contributions by leading researchers and scientists from academia and industry, this authoritative volume: Discusses the latest developments and issues in the area of corrosion inhibition, including manufacturing challenges and new industrial applications Explores the development and implementation of environmentally-friendly alternatives to traditional toxic corrosion inhibitors Covers both established and emerging classes of corrosion inhibitors as well as future research directions Describes the anticorrosive mechanisms and effects of acyclic, cyclic, natural, and synthetic corrosion inhibitors Offering an interdisciplinary approach to the subject, Organic Corrosion Inhibitors: Synthesis, Characterization, Mechanism, and Applications is essential reading for chemists, chemical engineers, researchers, industry professionals, and advanced students working in fields such as corrosion inhibitors, corrosion engineering, materials science, and applied chemistry.
| Author | : Paul T. Anastas |
| Publisher | : |
| Total Pages | : 446 |
| Release | : 2013 |
| Genre | : |
| ISBN | : |
| Author | : Santhosh Penta |
| Publisher | : Academic Press |
| Total Pages | : 191 |
| Release | : 2015-08-07 |
| Genre | : Science |
| ISBN | : 012803873X |
Advances in Structure and Activity Relationship of Coumarin Derivatives covers the structural behavior of various coumarin derivatives for various potential pharmaceutical applications. Based on substitution targeted for active sites, the book takes a rational approach for designing new and specific potent drugs, optimizing existing ones, and developing novel reactions. This focused primer describes the chemical structure and activity of coumarin derivatives to explore the effects of different substituents at specific positions, and their properties for effective bioactivity. - Accessible and current coverage of coumarin derivatives from structure to potential applications - Application of SAR technology to predict bioactivity of the derivatives based on its chemical structure - Information for researchers in medicinal chemistry, pharmaceutical sciences, and related fields
| Author | : Bimal Banik |
| Publisher | : Elsevier |
| Total Pages | : 1046 |
| Release | : 2020-03-27 |
| Genre | : Science |
| ISBN | : 0128175931 |
Extensive experimentation and high failure rates are a well-recognised downside to the drug discovery process, with the resultant high levels of inefficiency and waste producing a negative environmental impact. Sustainable and Green Approaches in Medicinal Chemistry reveals how medicinal and green chemistry can work together to directly address this issue. After providing essential context to the growth of green chemistry in relation to drug discovery in Part 1, the book goes on to identify a broad range of practical methods and synthesis techniques in Part 2. Part 3 reveals how medicinal chemistry techniques can be used to improve efficiency, mitigate failure and increase the environmental benignity of the entire drug discovery process, whilst Parts 4 and 5 discuss natural products and microwave-induced chemistry. Finally, the role of computers in drug discovery is explored in Part 6. - Identifies novel and cost effective green medicinal chemistry approaches for improved efficiency and sustainability - Reflects on techniques for a broad range of compounds and materials - Highlights sustainable and green chemistry pathways for molecular synthesis
| Author | : K. Murrell |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 520 |
| Release | : 2012-12-06 |
| Genre | : Science |
| ISBN | : 9400958781 |
Until quite recently conditions in industry were often rough. Long hours were worked in insanitary and murky workshops, often with little regard to the effects upon the workpeople who were considered to be expendable. Now, however, these adverse conditions have been recognized and so remedied that there remains little in industrial conditions to disturb the public conscience. This does not mean that conditions of work in office or factory are perfect. The obvious and dramatic abuses of the human frame may have gone, but in their place have arisen stresses and strains which, taking effect only in the long term, are generally undramatic and often unrecognized. They exist none the less. No organized effort to study the effect of working conditions on man's performance was made until the end of World War I, when the Industrial Fatigue Research Board was set up. For the first time, men trained in the human sciences entered industry to study men at work. They made con tributions which set a new standard of scientific investigation into human performance and allowed executive action on the basis of evidence rather than of hunch. The Board's work differed from the contribution of Gilbreth in America in that the principles of Motion Study which he developed were, to a large extent, based on intelligent observation rather than controlled experiment. During the 1920S the National Institute of Industrial Psychology was founded and there was close collaboration between it and the I.F.R.B.
| Author | : Charles Owens Wilson |
| Publisher | : Lippincott Williams & Wilkins |
| Total Pages | : 1150 |
| Release | : 1977 |
| Genre | : Medical |
| ISBN | : |
| Author | : Vishnu Ji Ram |
| Publisher | : Elsevier |
| Total Pages | : 504 |
| Release | : 2019-06-05 |
| Genre | : Science |
| ISBN | : 0081011911 |
Heterocycles are ubiquitously present in nature and occupy a unique place in organic chemistry as they are part of the DNA and haemoglobin that make life possible. The Chemistry of Heterocycles covers an introduction to the topic, followed by a chapter on the nomenclature of all classes of isolated, fused and polycyclic heterocycles. The third chapter delineates the highly strained three membered N,O and S containing aromatic and non-aromatic heterocycles with one and more than one similar and dissimilar heteroatom. The four-membered heterocycles are abundantly present in various natural and synthetic products of pharmacological importance. This chapter describes the natural abundance, synthesis, chemical reactivity, structural features and their medicinal importance. This class of compounds are present as sub-structures in penicillin and cytotoxic Taxol. Lastly, a chapter on the natural abundance, synthesis, chemical reactivity and pharmacological importance of 5-membered heterocycles with N,O,S heteroatom is covered. The chemistry of heterocycles with mixed heteroatom such as, N-S, N-O, N-S etc. is also described. - Gives in-depth, clear information about various systems of nomenclature along with widely acceptable IUPAC system for naming various classes of heterocycles - Provides complete information about natural occurrences, synthesis, chemical reactivity, pharmacological importance of heterocycles and their application in material science - Highly relevant for graduate students and researchers, providing updated information about various isolated and fused N,O and,S containing heterocycles
