Chemical Product Design And Formulation
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| Author | : E. L. Cussler |
| Publisher | : Cambridge University Press |
| Total Pages | : 453 |
| Release | : 2011-05-12 |
| Genre | : Technology & Engineering |
| ISBN | : 113949791X |
The chemical industry is changing, going beyond commodity chemicals to a palette of higher value added products. This groundbreaking book, now revised and expanded, documents this change and shows how to meet the challenges implied. Presenting a four-step design process - needs, ideas, selection, manufacture - the authors supply readers with a simple design template that can be applied to a wide variety of products. Four new chapters on commodities, devices, molecules/drugs and microstructures show how this template can be applied to products including oxygen for emphysema patients, pharmaceuticals like taxol, dietary supplements like lutein, and beverages which are more satisfying. For different groups of products the authors supply both strategies for design and summaries of relevant science. Economic analysis is expanded, emphasizing the importance of speed-to-market, selling ideas to investors and an expectation of limited time in the market. Extra examples, homework problems and a solutions manual are available.
| Author | : Ulrich Bröckel |
| Publisher | : John Wiley & Sons |
| Total Pages | : 367 |
| Release | : 2013-08-02 |
| Genre | : Technology & Engineering |
| ISBN | : 3527654763 |
Covering the whole value chain - from product requirements and properties via process technologies and equipment to real-world applications - this reference represents a comprehensive overview of the topic. The editors and majority of the authors are members of the European Federation of Chemical Engineering, with backgrounds from academia as well as industry. Therefore, this multifaceted area is highlighted from different angles: essential physico-chemical background, latest measurement and prediction techniques, and numerous applications from cosmetic up to food industry. Recommended reading for process, pharma and chemical engineers, chemists in industry, and those working in the pharmaceutical, food, cosmetics, dyes and pigments industries.
| Author | : E. L. Cussler |
| Publisher | : Cambridge University Press |
| Total Pages | : 152 |
| Release | : 2001-04-16 |
| Genre | : Science |
| ISBN | : 9780521791830 |
Until recently, the chemical industry has been dominated by the manufacture of bulk commodity chemicals such as benzene, ammonia, and polypropylene. However, over the last decade a significant shift occurred. Now most chemical companies devote any new resources to the design and manufacture of specialty, high value-added chemical products such as pharmaceuticals, cosmetics, and electronic coatings. Although the jobs held by chemical engineers have also changed to reflect this altered business, their training has remained static, emphasizing traditional commodities. This ground-breaking text starts to redress the balance between commodities and higher value-added products. It expands the scope of chemical engineering design to encompass both process design and product design. The authors use a four-step procedure for chemical product design - needs, ideas, selection, manufacture - drawing numerous examples from industry to illustrate the discussion. The book concludes with a brief review of the economic issues. Chemical engineering students and beginning chemical engineers will find this text an inviting introduction to chemical product design.
| Author | : Mary T. am Ende |
| Publisher | : John Wiley & Sons |
| Total Pages | : 1435 |
| Release | : 2019-04-08 |
| Genre | : Technology & Engineering |
| ISBN | : 111928550X |
A guide to the important chemical engineering concepts for the development of new drugs, revised second edition The revised and updated second edition of Chemical Engineering in the Pharmaceutical Industry offers a guide to the experimental and computational methods related to drug product design and development. The second edition has been greatly expanded and covers a range of topics related to formulation design and process development of drug products. The authors review basic analytics for quantitation of drug product quality attributes, such as potency, purity, content uniformity, and dissolution, that are addressed with consideration of the applied statistics, process analytical technology, and process control. The 2nd Edition is divided into two separate books: 1) Active Pharmaceutical Ingredients (API’s) and 2) Drug Product Design, Development and Modeling. The contributors explore technology transfer and scale-up of batch processes that are exemplified experimentally and computationally. Written for engineers working in the field, the book examines in-silico process modeling tools that streamline experimental screening approaches. In addition, the authors discuss the emerging field of continuous drug product manufacturing. This revised second edition: Contains 21 new or revised chapters, including chapters on quality by design, computational approaches for drug product modeling, process design with PAT and process control, engineering challenges and solutions Covers chemistry and engineering activities related to dosage form design, and process development, and scale-up Offers analytical methods and applied statistics that highlight drug product quality attributes as design features Presents updated and new example calculations and associated solutions Includes contributions from leading experts in the field Written for pharmaceutical engineers, chemical engineers, undergraduate and graduation students, and professionals in the field of pharmaceutical sciences and manufacturing, Chemical Engineering in the Pharmaceutical Industry, Second Edition contains information designed to be of use from the engineer's perspective and spans information from solid to semi-solid to lyophilized drug products.
| Author | : Ka M. Ng |
| Publisher | : Elsevier |
| Total Pages | : 513 |
| Release | : 2006-10-24 |
| Genre | : Technology & Engineering |
| ISBN | : 0080466745 |
Chemical Product Design: Towards a Perspective through Case Studies provides a framework for chemical product design problems which are clearly defined together with different solution approaches. This book covers the latest methods and tools currently available in the field and discusses future challenges that the chemical industry is faced with. It focuses on important issues of chemical product design and provides a good overview on industrial chemical product design problems through case studies supplied by leading experts. The editors of Chemical Product Design teach chemical product design at graduate level courses and also serve as consultants for various chemical companies. They have also developed experimental techniques for chemical product design as well as computer-aided design methods and tools. - Highlights important issues of chemical product design through case studies - Case studies supplied by leading experts in chemical product design - Provides a complete framework for chemical product design
| Author | : Ali Elkamel |
| Publisher | : John Wiley & Sons |
| Total Pages | : 229 |
| Release | : 2023-04-03 |
| Genre | : Technology & Engineering |
| ISBN | : 3527332642 |
Chemical Product Formulation Design and Optimization Explore the cutting-edge in chemical product formulation and design In Chemical Product Formulation Design and Optimization: Methods, Techniques, and Case Studies, a team of renowned technologists and engineers delivers a practice guide to chemical product design. Offering real-world case studies for disinfectant formulation, the optimization of defined media, and the formulation of biocomposites, the book contains introduction to the current product design process. In addition to the background of related statistical techniques, readers will find: Clear illustrations, figures, and tables that improve understanding and retention of critical topics Thorough introductions to the mathematical principles of chemical product design A complete examination of intellectual property considerations in the chemical product design process Ideal for process and chemical engineers, Chemical Product Formulation Design and Optimization: Methods, Techniques, and Case Studies is a must-read resource for professionals in the pharmaceutical and cosmetics industry as well as chemical engineers working in the food, paint, and dye industries who seek a one-stop resource that includes the latest advances in chemical product formulation.
| Author | : David J. am Ende |
| Publisher | : John Wiley & Sons |
| Total Pages | : 1172 |
| Release | : 2019-04-23 |
| Genre | : Technology & Engineering |
| ISBN | : 1119285860 |
A guide to the development and manufacturing of pharmaceutical products written for professionals in the industry, revised second edition The revised and updated second edition of Chemical Engineering in the Pharmaceutical Industry is a practical book that highlights chemistry and chemical engineering. The book’s regulatory quality strategies target the development and manufacturing of pharmaceutically active ingredients of pharmaceutical products. The expanded second edition contains revised content with many new case studies and additional example calculations that are of interest to chemical engineers. The 2nd Edition is divided into two separate books: 1) Active Pharmaceutical Ingredients (API’s) and 2) Drug Product Design, Development and Modeling. The active pharmaceutical ingredients book puts the focus on the chemistry, chemical engineering, and unit operations specific to development and manufacturing of the active ingredients of the pharmaceutical product. The drug substance operations section includes information on chemical reactions, mixing, distillations, extractions, crystallizations, filtration, drying, and wet and dry milling. In addition, the book includes many applications of process modeling and modern software tools that are geared toward batch-scale and continuous drug substance pharmaceutical operations. This updated second edition: Contains 30new chapters or revised chapters specific to API, covering topics including: manufacturing quality by design, computational approaches, continuous manufacturing, crystallization and final form, process safety Expanded topics of scale-up, continuous processing, applications of thermodynamics and thermodynamic modeling, filtration and drying Presents updated and expanded example calculations Includes contributions from noted experts in the field Written for pharmaceutical engineers, chemical engineers, undergraduate and graduate students, and professionals in the field of pharmaceutical sciences and manufacturing, the second edition of Chemical Engineering in the Pharmaceutical Industryf ocuses on the development and chemical engineering as well as operations specific to the design, formulation, and manufacture of drug substance and products.
| Author | : Gavin Towler |
| Publisher | : Elsevier |
| Total Pages | : 1321 |
| Release | : 2012-01-25 |
| Genre | : Technology & Engineering |
| ISBN | : 0080966608 |
Chemical Engineering Design, Second Edition, deals with the application of chemical engineering principles to the design of chemical processes and equipment. Revised throughout, this edition has been specifically developed for the U.S. market. It provides the latest US codes and standards, including API, ASME and ISA design codes and ANSI standards. It contains new discussions of conceptual plant design, flowsheet development, and revamp design; extended coverage of capital cost estimation, process costing, and economics; and new chapters on equipment selection, reactor design, and solids handling processes. A rigorous pedagogy assists learning, with detailed worked examples, end of chapter exercises, plus supporting data, and Excel spreadsheet calculations, plus over 150 Patent References for downloading from the companion website. Extensive instructor resources, including 1170 lecture slides and a fully worked solutions manual are available to adopting instructors. This text is designed for chemical and biochemical engineering students (senior undergraduate year, plus appropriate for capstone design courses where taken, plus graduates) and lecturers/tutors, and professionals in industry (chemical process, biochemical, pharmaceutical, petrochemical sectors). New to this edition: - Revised organization into Part I: Process Design, and Part II: Plant Design. The broad themes of Part I are flowsheet development, economic analysis, safety and environmental impact and optimization. Part II contains chapters on equipment design and selection that can be used as supplements to a lecture course or as essential references for students or practicing engineers working on design projects. - New discussion of conceptual plant design, flowsheet development and revamp design - Significantly increased coverage of capital cost estimation, process costing and economics - New chapters on equipment selection, reactor design and solids handling processes - New sections on fermentation, adsorption, membrane separations, ion exchange and chromatography - Increased coverage of batch processing, food, pharmaceutical and biological processes - All equipment chapters in Part II revised and updated with current information - Updated throughout for latest US codes and standards, including API, ASME and ISA design codes and ANSI standards - Additional worked examples and homework problems - The most complete and up to date coverage of equipment selection - 108 realistic commercial design projects from diverse industries - A rigorous pedagogy assists learning, with detailed worked examples, end of chapter exercises, plus supporting data and Excel spreadsheet calculations plus over 150 Patent References, for downloading from the companion website - Extensive instructor resources: 1170 lecture slides plus fully worked solutions manual available to adopting instructors
| Author | : Vitthal S. Kulkarni |
| Publisher | : Academic Press |
| Total Pages | : 256 |
| Release | : 2015-10-15 |
| Genre | : Science |
| ISBN | : 012801072X |
A needed resource for pharmaceutical scientists and cosmetic chemists, Essential Chemistry for Formulators of Semisolid and Liquid Dosages provides insight into the basic chemistry of mixing different phases and test methods for the stability study of nonsolid formulations. The book covers foundational surface/colloid chemistry, which forms the necessary background for making emulsions, suspensions, solutions, and nano drug delivery systems, and the chemistry of mixing, which is critical for further formulation of drug delivery systems into semisolid (gels, creams, lotions, and ointments) or liquid final dosages. Expanding on these foundational principles, this useful guide explores stability testing methods, such as particle size, rheological/viscosity, microscopy, and chemical, and closes with a valuable discussion of regulatory issues. Essential Chemistry for Formulators of Semisolid and Liquid Dosages offers scientists and students the foundation and practical guidance to make and analyze semisolid and liquid formulations. - Unique coverage of the underlying chemistry that makes possible stable dosages - Quality content written by experienced experts from the drug development industry - Valuable information for academic and industrial scientists developing topical and liquid dosage formulations for pharmaceutical as well as skin care and cosmetic products
| Author | : John Blacker |
| Publisher | : Royal Society of Chemistry |
| Total Pages | : 375 |
| Release | : 2011-08-17 |
| Genre | : Science |
| ISBN | : 1849733074 |
Pharmaceutical process research and development is an exacting, multidisciplinary effort but a somewhat neglected discipline in the chemical curriculum. This book presents an overview of the many facets of process development and how recent advances in synthetic organic chemistry, process technology and chemical engineering have impacted on the manufacture of pharmaceuticals. In 15 concise chapters the book covers such diverse subjects as route selection and economics, the interface with medicinal chemistry, the impact of green chemistry, safety, the crucial role of physical organic measurements in gaining a deeper understanding of chemical behaviour, the role of the analyst, new tools and innovations in reactor design, purification and separation, solid state chemistry and its role in formulation. The book ends with an assessment of future trends and challenges. The book provides a valuable overview of: both early and late stage chemical development, how safe and scaleable synthetic routes are designed, selected and developed, the importance of the chemical engineering, analytical and manufacturing interfaces, the key enabling technologies, including catalysis and biocatalysis, the importance of the green chemical perspective and solid form issues. The book, written and edited by experts in the field, is a contemporary, holistic treatise, with a logical sequence for process development and mini-case histories within the chapters to bring alive different aspects of the process. It is completely pharmaceutical themed, encompassing all essential aspects, from route and reagent selection to manufacture of the active compound. The book is aimed at both graduates and postgraduates interested in a career in the pharmaceutical industry. It informs them about the breadth of the work carried out in chemical research and development departments, and gives them a feel for the challenges involved in the job. The book is also of value to academics who often understand the drug discovery arena, but have far less appreciation of the drug development area, and are thus unable to advise their students about the relative merits of careers in chemical development versus discovery.
