Centenarians—A Model to Study the Molecular Basis of Lifespan and Healthspan

Centenarians—A Model to Study the Molecular Basis of Lifespan and Healthspan
Author: Annibale Puca
Publisher: MDPI
Total Pages: 204
Release: 2021-06-15
Genre: Science
ISBN: 3036509801
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People around the world are living longer. For the first time in history, most humans will live to be sixty and beyond. By 2050, the world's population aged 60 and over will reach a total of 2 billion, up from 900 million in 2015. Today, 125 million people are 80 years of age or older. By 2050, there will be 434 million people in this age group worldwide. In addition, the pace of aging of the world population is also increasing. However, there is not enough evidence to show that older people have better health than their parents. While rates of severe disability have declined over the past 30 years (but only in high-income countries), there have been no significant changes in mild to moderate disability over the same period of time. Indeed, the increase in the duration of life (lifespan) does not coincide with the increase in the duration of health (healthspan), that is, the period of life free from serious chronic diseases and disabilities. Therefore, the identification of the factors that predispose to a long and healthy life, as discussed in the papers of this book, is of enormous interest for translational medicine.

Handbook of Anti-Aging Medicine

Handbook of Anti-Aging Medicine
Author: Prof Dr Mike KS Chan
Publisher: EUROPEAN WELLNESS ACADEMY
Total Pages: 607
Release: 2023-01-16
Genre: Medical
ISBN: 1662930216
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This handbook focuses on different aspects of anti-aging and both preventive and regenerative medicine. It includes analysis of the paradigm of ageing and concepts of anti-aging medicine. Standards and technologies are highlighted in over twenty chapters all authored by international experts in regenerative medicine. Topics covered include: • Ageing, aging, and anti-aging: A Decalogue for anti-aging medicine • Lessons from Sicilian centenarians for anti-aging medicine • Molecular biomarkers and genetic aspects of aging • Future of peptides in clinical practice • Mitochondrial approaches in anti-aging medicine and in SARS-CoV2 infection • Tissue-specific autoantibodies in preventive medicine • Chronic stress as a psycho-neuro-immunological dysfunction • Gut-associated immune system and its health implications • Regenerative medicine with platelet-rich-plasma • Alzheimer’s disease: Preventive and anti-aging neurology • Autistic spectrum disorder and mitochondrial medicine • Integrative hormonal approach in anti-aging medicine • Preventive cardiology and phlebology • Aesthetic and anti-aging medicine • Preventive ophthalmology • Preventive oncology • Nutrition in healthy aging • Physical activity and fitness paradigms for anti-aging and longevity Recommended reading for clinicians working in anti-aging medicine as well as ageing people. The authors hope it will set a new “standard of anti-aging medicine” and as a tool in planning for the inevitable challenges we all will face caring for ageing patients and creating preventive-health programs.

Nanotechnology Based Delivery of Phytoconstituents and Cosmeceuticals

Nanotechnology Based Delivery of Phytoconstituents and Cosmeceuticals
Author: Deep Pooja
Publisher: Springer Nature
Total Pages: 353
Release: 2024-01-10
Genre: Medical
ISBN: 9819953146
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This book explores the role of nanotechnology in the delivery of natural phytoconstituents and cosmeceuticals. It presents polymeric nanocarriers, lipid-based nanocarriers, metal/metal oxide nanocarriers, protein nanocarriers, and dendrimers for the delivery of phytoconstituents. Further, it focuses on the usage of phytocompounds in various cosmeceutical products and nano delivery technologies used in the delivery of various cosmeceuticals. Finally, the book reviews the toxicity issues of nanoparticles in the delivery of phytoconstituents and cosmeceuticals and regulatory aspects for clinical applications of nano phytomedicines. This book is helpful for academicians and researchers working in pharmaceutical sciences, nano science, material science, plant science, and cosmetic science.

Exceptional Longevity

Exceptional Longevity
Author: Bernard Jeune
Publisher:
Total Pages: 180
Release: 1995
Genre: Health & Fitness
ISBN:
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States that the number of genuine long-livers is exploding and a substantial proportion of new-borns in developed countries may survive to celebrate their 100th birthday. This book examines the storied realms of exceptional longevity.

Epigenetics of Aging

Epigenetics of Aging
Author: Trygve O. Tollefsbol
Publisher: Springer Science & Business Media
Total Pages: 462
Release: 2009-11-11
Genre: Medical
ISBN: 1441906398
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Recent studies have indicated that epigenetic processes may play a major role in both cellular and organismal aging. These epigenetic processes include not only DNA methylation and histone modifications, but also extend to many other epigenetic mediators such as the polycomb group proteins, chromosomal position effects, and noncoding RNA. The topics of this book range from fundamental changes in DNA methylation in aging to the most recent research on intervention into epigenetic modifications to modulate the aging process. The major topics of epigenetics and aging covered in this book are: 1) DNA methylation and histone modifications in aging; 2) Other epigenetic processes and aging; 3) Impact of epigenetics on aging; 4) Epigenetics of age-related diseases; 5) Epigenetic interventions and aging: and 6) Future directions in epigenetic aging research. The most studied of epigenetic processes, DNA methylation, has been associated with cellular aging and aging of organisms for many years. It is now apparent that both global and gene-specific alterations occur not only in DNA methylation during aging, but also in several histone alterations. Many epigenetic alterations can have an impact on aging processes such as stem cell aging, control of telomerase, modifications of telomeres, and epigenetic drift can impact the aging process as evident in the recent studies of aging monozygotic twins. Numerous age-related diseases are affected by epigenetic mechanisms. For example, recent studies have shown that DNA methylation is altered in Alzheimer’s disease and autoimmunity. Other prevalent diseases that have been associated with age-related epigenetic changes include cancer and diabetes. Paternal age and epigenetic changes appear to have an effect on schizophrenia and epigenetic silencing has been associated with several of the progeroid syndromes of premature aging. Moreover, the impact of dietary or drug intervention into epigenetic processes as they affect normal aging or age-related diseases is becoming increasingly feasible.

Current Perspectives on Centenarians

Current Perspectives on Centenarians
Author: Raya Elfadel Kheirbek
Publisher: Springer Nature
Total Pages: 273
Release: 2023-10-23
Genre: Social Science
ISBN: 3031309154
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This book explores various aspects related to human longevity and aging beyond 100 years old. It examines all domains of health and well-being of this elite group including the current demographics, genetics and epigenetics of exceptional longevity, cardiovascular risk factors, dementia, nutrition, physical activity, African American and Hispanic centenarians, financial planning, religion, spirituality, whole health, wellness, oral health, and nature. The book also delves into the lives of supercentenarians, defined as expert survivors who have lived beyond 110 years old. The implications of the Age-Friendly Healthcare Systems (AFHS) Movement on the care of centenarians are also discussed. This book is a valuable resource for healthcare professionals, epidemiologists, public health professionals, policy makers, and anyone interested in the study of aging and longevity.

Business Engagement in Building Healthy Communities

Business Engagement in Building Healthy Communities
Author: Institute of Medicine
Publisher: National Academies Press
Total Pages: 139
Release: 2015-05-08
Genre: Medical
ISBN: 0309316693
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Business Engagement in Building Healthy Communities is the summary of a workshop convened by the Institute of Medicine's Roundtable on Population Health Improvement in July 2014 to consider the role of business in improving population health beyond the usual worksite wellness and health promotion activities. The workshop followed previous roundtable discussions on the importance of applying a health lens to decision making in non-health sectors and the need for cross-sector collaborations to advance population health. Invited speakers included representatives from several businesses that have taken action to improve the health of their communities and representatives of business coalitions on health. The workshop was designed to discuss why engaging in population health improvement is good for business; explore how businesses can be effective key leaders in improving the health of communities; and discuss ways in which businesses can engage in population health improvement. This report is a record of the presentations and discussion of the event

Molecular Basis and Emerging Strategies for Anti-aging Interventions

Molecular Basis and Emerging Strategies for Anti-aging Interventions
Author: Syed Ibrahim Rizvi
Publisher: Springer
Total Pages: 386
Release: 2018-11-02
Genre: Medical
ISBN: 9811316996
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This book describes the nature of aging, age-related disorders, and the molecular principles of emerging strategies for anti-aging interventions, while also discussing the discovery of targets for geroprotective drugs. Although significant medical advances in the treatment and eradication of life-threatening conditions such as cardiovascular and infectious disease have been made over the past five decades, the prevalence of age-related disorders still remains high in older populations. Intervening into aging is the next frontier in contemporary medicine, and will be of increasing importance over time, as other sources of poor health are combated more and more successfully. Given the universal interest in anti-aging strategies, the book will appeal to a very broad audience. It addresses a diverse range of anti-aging interventions – including stem cells, autophagy, senolytics, anti-inflammatory methods, and telomerase induction – that will be of interest to scientists and researchers from various disciplines in the life sciences.

Molecular Basis of Nutrition and Aging

Molecular Basis of Nutrition and Aging
Author: Marco Malavolta
Publisher: Academic Press
Total Pages: 786
Release: 2016-04-15
Genre: Science
ISBN: 0128018275
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Molecular Basis of Nutrition and Aging: A Volume in the Molecular Nutrition Series focuses on the nutritional issues associated with aging and the important metabolic consequences of diet, nutrition, and health. The book is subdivided into four parts that reflect the impact of nutrition from a biomolecular level to individual health. In Part One, chapters explore the general aspects of aging, aging phenotypes, and relevant aspects of nutrition related to the elderly and healthy aging. Part Two includes molecular and cellular targets of nutrition in aging, with chapters exploring lipid peroxidation, inflammaging, anabolic and catabolic signaling, epigenetics, DNA damage and repair, redox homeostasis, and insulin sensitivity, among others. Part Three looks at system-level and organ targets of nutrition in aging, including a variety of tissues, systems, and diseases, such as immune function, the cardiovascular system, the brain and dementia, muscle, bone, lung, and many others. Finally, Part Four focuses on the health effects of specific dietary compounds and dietary interventions in aging, including vitamin D, retinol, curcumin, folate, iron, potassium, calcium, magnesium, zinc, copper, selenium, iodine, vitamin B, fish oil, vitamin E, resveratrol, polyphenols, vegetables, and fruit, as well as the current nutritional recommendations. - Offers updated information and a perspectives on important future developments to different professionals involved in the basic and clinical research on all major nutritional aspects of aging - Explores how nutritional factors are involved in the pathogenesis of aging across body systems - Investigates the molecular and genetic basis of aging and cellular senescence through the lens of the rapidly evolving field of molecular nutrition

Decoding Longevity: Secrets Of The Centenarians

Decoding Longevity: Secrets Of The Centenarians
Author: GEW SOCIAL SCIENCES GROUP
Publisher: Global East-West
Total Pages: 157
Release: 2024-06-15
Genre: Health & Fitness
ISBN:
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The book explores the multifaceted quest for longevity, delving deeply into the various factors that contribute to living a prolonged, healthy life beyond the average lifespan. 1. The Quest for Longevity: Longevity is not merely about living longer; it encompasses genetics, lifestyle, environment, and medical advancements, all driven by a fundamental human drive to thrive and leave a lasting legacy. It symbolizes resilience, wisdom, and a deeper significance beyond mere numbers. 2. Historical Perspectives on Long Life: The fascination with longevity dates back to ancient Chinese, Indian, and Greek civilizations, which pursued immortality through alchemy, diet, and lifestyle. This pursuit evolved with the Age of Enlightenment and the Industrial Revolution, which brought scientific methods and increased life expectancy. Modern advancements continue to unlock the mysteries of human longevity. 3. The Significance of Reaching a Century: Reaching 100 years old is seen as a mark of a resilient and wise life. Centenarians challenge traditional views on aging, retirement, and healthcare, reflecting societal progress in medical science and life quality. They inspire hope and necessitate new approaches to supporting the elderly. 4. Global Variations in Lifespan: Lifespan varies globally due to socioeconomic disparities, cultural practices, and regional lifestyles. Some 'longevity hotspots' boast high numbers of centenarians, attributed to beneficial lifestyle and social practices. Globalization and the spread of medical knowledge are reshaping longevity patterns around the world. 5. Biological Versus Environmental Factors: Both genetics and environmental factors like diet, exercise, and social interactions play critical roles in longevity. Understanding the balance between these influences offers avenues for tailored interventions to promote healthy aging and prevent diseases. 6. Modern Science and the Pursuit of Extended Life: Modern science is harnessing genomics, regenerative medicine, and advanced technologies like AI and machine learning to extend human life. Personalization in medicine and targeted interventions are making significant strides towards understanding and enhancing longevity. Overall, the book underscores the complex interplay of historical, biological, environmental, and modern technological factors in the human quest for a longer, healthier life.