Cell Signal Transduction, Second Messengers, and Protein Phosphorylation in Health and Disease

Cell Signal Transduction, Second Messengers, and Protein Phosphorylation in Health and Disease
Author: A.M. Municio
Publisher: Springer Science & Business Media
Total Pages: 255
Release: 2012-12-06
Genre: Science
ISBN: 1461518792

It is the great glory as it is also the great threat of science that everything which is in principle possible can be done if the intention to do it is sufficiently resolute. Peter Medawar, "The Threat and the Glory" An international symposium on "Cell Signal Transduction, Second Messengers, and Protein Phosphorylation in Health and Disease" was held at EI Escorial (Spain) from July 5-9, 1993 as a summer course of the Complutense University in Madrid. The lectures were delivered by renowned scientists from Europe, America, and Asia and attended by a large number of young scientists and graduate students from many countries. During evolution multicellular organisms have developed the most sophisticated and heterogeneous signals to maintain in harmony their multiple functions. The latest and most controversial aspects and developments in signal transduction were the main focus of this course. The communication among participants was extremely fluid, alive, and warm. This allowed the understanding of the key steps in cellular communication, from their original and historical sources to the main present hypothesis in the borderline of the latest scientific discoveries in this field. Without any doubt, the special atmosphere of the place, the monuments and the old granite stones, the "patio" with the fountain and the rose garden were responsible for the cordial meeting. This book comprises the manuscripts of the participants and we hope it will contribute to our knowledge of cellular signal transduction and be of value to a wider scientific community.

Lipid Second Messengers

Lipid Second Messengers
Author: Ronald P. Rubin
Publisher: CRC Press
Total Pages: 168
Release: 2020-10-14
Genre: Science
ISBN: 1000153592

Lipid Second Messengers provides detailed methodology for analysis of various lipid signaling pathways. Authoritative contributors explain the factors that regulate lipid second messenger production by agonist-activated enzymes and examine their products. Topics discussed include procedures used to measure lipid-derived mediators such as lysophospholipids, arachidonic acid, eicosanoids, anandamide, and ceramides, and the enzymes responsible for generating these messengers, such as phospholipases, prostaglandin endoperoxide synthases, and sphingomyelinase.

Signaling Mechanisms Regulating T Cell Diversity and Function

Signaling Mechanisms Regulating T Cell Diversity and Function
Author: Jonathan Soboloff
Publisher: CRC Press
Total Pages: 258
Release: 2017-03-27
Genre: Medical
ISBN: 149870509X

T cells play a vital role mediating adaptive immunity, a specific acquired resistance to an infectious agent produced by the introduction of an antigen. There are a variety of T cell types with different functions. They are called T cells, because they are derived from the thymus gland. This volume discusses how T cells are regulated through the operation of signaling mechanisms. Topics covered include positive and negative selection, early events in T cell receptor engagement, and various T cell subsets.

Neuromorphic Olfaction

Neuromorphic Olfaction
Author: Krishna C. Persaud
Publisher: CRC Press
Total Pages: 237
Release: 2016-04-19
Genre: Medical
ISBN: 1439871728

Many advances have been made in the last decade in the understanding of the computational principles underlying olfactory system functioning. Neuromorphic Olfaction is a collaboration among European researchers who, through NEUROCHEM (Fp7-Grant Agreement Number 216916)-a challenging and innovative European-funded project-introduce novel computing p

Cellular Signal Transduction in Toxicology and Pharmacology

Cellular Signal Transduction in Toxicology and Pharmacology
Author: Jonathan W. Boyd
Publisher: John Wiley & Sons
Total Pages: 336
Release: 2019-04-16
Genre: Science
ISBN: 1119060265

Covering a key topic due to growing research into the role of signaling mechanisms in toxicology, this book focuses on practical approaches for informatics, big data, and complex data sets. Combines fundamentals / basics with experimental applications that can help those involved in preclinical drug studies and translational research Includes detailed presentations of study methodology and data collection, analysis, and interpretation Discusses tools like experimental design, sample handling, analytical measurement techniques

Zinc Signaling

Zinc Signaling
Author: Toshiyuki Fukada
Publisher: Springer Nature
Total Pages: 412
Release: 2019-12-13
Genre: Medical
ISBN: 9811505578

This book, now in an extensively revised second edition, describes the crucial role of zinc signaling in biological processes on a molecular and physiological basis. Global leaders in the field review the latest knowledge, including the very significant advances in understanding that have been achieved since publication of the first edition. Detailed information is provided on all the essentials of zinc signaling, covering molecular aspects and the roles of zinc transporters, the zinc sensing receptor, and metallothioneins. Detection techniques for zinc signals, involving genetically encoded and chemical probes, are also described. The critical contributions of the zinc signal in maintaining health and the adverse consequences of any imbalance in the signal are then thoroughly addressed. Here, readers will find up-to-date information on the significance of the zinc signal in a wide range of conditions, including cardiovascular disorders, neurodegenerative diseases, diabetes, autoimmune diseases, inflammatory conditions, skin disease, osteoarthritis, and cancer. The book will be of value for researchers, clinicians, and advanced students.

International Textbook of Diabetes Mellitus

International Textbook of Diabetes Mellitus
Author: R. A. DeFronzo
Publisher: John Wiley & Sons
Total Pages: 1200
Release: 2015-03-11
Genre: Medical
ISBN: 1118387678

The International Textbook of Diabetes Mellitus has been a successful, well-respected medical textbook for almost 20 years, over 3 editions. Encyclopaedic and international in scope, the textbook covers all aspects of diabetes ensuring a truly multidisciplinary and global approach. Sections covered include epidemiology, diagnosis, pathogenesis, management and complications of diabetes and public health issues worldwide. It incorporates a vast amount of new data regarding the scientific understanding and clinical management of this disease, with each new edition always reflecting the substantial advances in the field. Whereas other diabetes textbooks are primarily clinical with less focus on the basic science behind diabetes, ITDM's primary philosophy has always been to comprehensively cover the basic science of metabolism, linking this closely to the pathophysiology and clinical aspects of the disease. Edited by four world-famous diabetes specialists, the book is divided into 13 sections, each section edited by a section editor of major international prominence. As well as covering all aspects of diabetes, from epidemiology and pathophysiology to the management of the condition and the complications that arise, this fourth edition also includes two new sections on NAFLD, NASH and non-traditional associations with diabetes, and clinical trial evidence in diabetes. This fourth edition of an internationally recognised textbook will once again provide all those involved in diabetes research and development, as well as diabetes specialists with the most comprehensive scientific reference book on diabetes available.

Cooperation of Liver Cells in Health and Disease

Cooperation of Liver Cells in Health and Disease
Author: Z. Kmiec
Publisher: Springer Science & Business Media
Total Pages: 154
Release: 2013-06-29
Genre: Science
ISBN: 3642565530

It is only during the last decade that the functions of sinusoidal endothelial cells, Kupffer cells, hepatic stellate cells, pit cells and other intrahepatic lymphocytes have been better understood. The development of methods for isolation and co-culturing various types of liver cells has established that they communicate and cooperate via secretion of various intercellular mediators. This monograph summarizes multiple data that suggest the important role of cellular cross-talk for the functions of both normal and diseased liver. Special features of the book include concise presentation of the majority of detailed data in 19 tables. Original schemes allow for the clear illustration of complicated intercellular relationships. This is the first ever presentation of the newly emerging field of liver biology, which is important for hepatic function in health and disease and opens new avenues for therapeutic interventions.

Calcium Entry Channels in Non-Excitable Cells

Calcium Entry Channels in Non-Excitable Cells
Author: Juliusz Ashot Kozak
Publisher: CRC Press
Total Pages: 343
Release: 2017-07-14
Genre: Science
ISBN: 149875273X

Calcium Entry Channels in Non-Excitable Cells focuses on methods of investigating the structure and function of non-voltage gated calcium channels. Each chapter presents important discoveries in calcium entry pathways, specifically dealing with the molecular identification of store-operated calcium channels which were reviewed by earlier volumes in the Methods in Signal Transduction series. Crystallographic and pharmacological approaches to the study of calcium channels of epithelial cells are also discussed. Calcium ion is a messenger in most cell types. Whereas voltage gated calcium channels have been studied extensively, the non-voltage gated calcium entry channel genes have only been identified relatively recently. The book will fill this important niche.