Cell Press Reviews Cancer Therapeutics
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| Author | : Cell Press |
| Publisher | : Elsevier |
| Total Pages | : 323 |
| Release | : 2013-12-10 |
| Genre | : Medical |
| ISBN | : 0127999175 |
Cell Press Reviews: Cancer Therapeutics informs, inspires, and connects cancer researchers at all stages in their careers with timely, comprehensive reviews written by leaders in the field and curated by Cell Press editors. The publicatio offers a broad view of some of the most compelling topics in cancer therapeutics including: - Genetic approaches for personal oncology - Targeting epigenetic dysregulation and protein interaction networks - Vaccines and antibodies in cancer immunotherapy - Tumor heterogeneity and chemotherapy resistance - Tumor associated macrophages in anticancer treatment Contributions come from leading voices in the field, including: - Daniel A. Haber, Director of Massachusetts General Hospital Cancer Center and Professor at Harvard Medical School - Tony Kouzarides, Professor at the University of Cambridge, Deputy Director of the Wellcome Trust/Cancer Research UK Gurdon Institute, and a founder of the cancer drug discovery company Chroma Therapeutics - Charles L. Sawyers, Chair of the Human Oncology and Pathogenesis Program at Memorial Sloan Kettering Cancer Center, President of the American Association for Cancer Research, member of the presidentially appointed National Cancer Advisory Board, and recipient of the 2013 Breakthrough Prize in Life Sciences Cell Press Reviews: Cancer Therapeutics is part of the Cell Press Reviews series, which features reviews published in Cell Press primary research and Trends reviews journals. - Provides timely, comprehensive articles on a wide range of topics in cancer therapeutics - Offers insight from experts on genetic, molecular, and cellular aspects of cancer therapy - Features reviews on basic science advances translated into drug discovery and therapeutic approaches - Includes articles originally published in Cell, Cancer Cell, Trends in Genetics, Trends in Molecular Medicine, and Trends in Pharmacological Sciences
| Author | : Lauren Pecorino |
| Publisher | : Oxford University Press, USA |
| Total Pages | : 365 |
| Release | : 2012-04-26 |
| Genre | : Medical |
| ISBN | : 019957717X |
Demonstrating how the malfunction of normal molecular pathways and components can lead to cancer, this text explores how our understanding of these defective mechanisms can be harnessed to develop new targeted therapeutic agents.
| Author | : Athena Aktipis |
| Publisher | : Princeton University Press |
| Total Pages | : 256 |
| Release | : 2020-03-24 |
| Genre | : Medical |
| ISBN | : 0691163847 |
A fundamental and groundbreaking reassessment of how we view and manage cancer When we think of the forces driving cancer, we don’t necessarily think of evolution. But evolution and cancer are closely linked because the historical processes that created life also created cancer. The Cheating Cell delves into this extraordinary relationship, and shows that by understanding cancer’s evolutionary origins, researchers can come up with more effective, revolutionary treatments. Athena Aktipis goes back billions of years to explore when unicellular forms became multicellular organisms. Within these bodies of cooperating cells, cheating ones arose, overusing resources and replicating out of control, giving rise to cancer. Aktipis illustrates how evolution has paved the way for cancer’s ubiquity, and why it will exist as long as multicellular life does. Even so, she argues, this doesn’t mean we should give up on treating cancer—in fact, evolutionary approaches offer new and promising options for the disease’s prevention and treatments that aim at long-term management rather than simple eradication. Looking across species—from sponges and cacti to dogs and elephants—we are discovering new mechanisms of tumor suppression and the many ways that multicellular life-forms have evolved to keep cancer under control. By accepting that cancer is a part of our biological past, present, and future—and that we cannot win a war against evolution—treatments can become smarter, more strategic, and more humane. Unifying the latest research from biology, ecology, medicine, and social science, The Cheating Cell challenges us to rethink cancer’s fundamental nature and our relationship to it.
| Author | : |
| Publisher | : |
| Total Pages | : 21 |
| Release | : 1964 |
| Genre | : |
| ISBN | : |
| Author | : Heide Schatten |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 382 |
| Release | : 2013-09-27 |
| Genre | : Science |
| ISBN | : 1627036342 |
Highlighting recent advances in our understanding of breast cancer, this book is intended for a wide audience as a reference book. Included are reviews of genetics, epigenetics, various aspects of cell and molecular biology, and several other areas of breast cancer that are aimed at determining new intervention sites for treatments and cures of the disease. The chapters are written by internationally recognized experts and include reviews of key topics in breast cancer research. Each chapter highlights the new aspects of specific research topics and the various impacts of designing new strategies as well as identifies new targets for therapeutic intervention. The topics addressed are selected to be of interest to patients, scientists, students, teachers, and anyone else interested in expanding their knowledge of breast cancer imaging, diagnostics, therapeutics, or basic biomedical research on breast cancer.
| Author | : P. B. Medawar |
| Publisher | : Basic Books |
| Total Pages | : 132 |
| Release | : 2008-08-01 |
| Genre | : Science |
| ISBN | : 0786722622 |
To those interested in a life in science, Sir Peter Medawar, Nobel laureate, deflates the myths of invincibility, superiority, and genius; instead, he demonstrates it is common sense and an inquiring mind that are essential to the scientist's calling. He deflates the myths surrounding scientists -- invincibility, superiority, and genius; instead, he argues that it is common sense and an inquiring mind that are essential to the makeup of a scientist. He delivers many wry observations on how to choose a research topic, how to get along wih collaborators and older scientists and administrators, how (and how not) to present a scientific paper, and how to cope with culturally "superior" specialists in the arts and humanities.
| Author | : Robin Hesketh |
| Publisher | : Cambridge University Press |
| Total Pages | : 355 |
| Release | : 2013 |
| Genre | : Medical |
| ISBN | : 1107013984 |
A concise overview of the fundamental concepts of cancer biology, ideal for those with little or no background in the field. From cancer epidemiology and the underlying mechanisms, through to tumour detection and treatment, the comprehensive picture revealed will enable students to move into the cancer field with confidence.
| Author | : Guillermina Lozano |
| Publisher | : |
| Total Pages | : 0 |
| Release | : 2016 |
| Genre | : Medical |
| ISBN | : 9781621821335 |
Decades of research on the tumor suppressor p53 have revealed that it plays a significant role as a "guardian of the genome," protecting cells against genotoxic stress. In recent years, p53 research has begun to move into the clinic in attempts to understand how p53 is frequently inactivated in-and sometimes even promotes-human cancer. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine covers the rapid progress that has recently been made in basic and clinical research on p53. The contributors review new observations about its basic biology, providing updates on the functions of its isoforms and domains, the myriad stresses and signals that trigger its activation or repression, and its downstream effects on genome stability and the cell cycle that enforce tumor suppression in different cell and tissue types. They also discuss how p53 dysfunction contributes to cancer, exploring the various inherited and somatic mutations in the human TP53 gene, the impact of mutant p53 proteins on tumorigenesis, and the prognostic value and clinical outcomes of these mutations. Drugs that are being developed to respond to tumors harboring aberrant p53 are also described. This book is therefore essential reading for all cancer biologists, cell and molecular biologists, and pharmacologists concerned with the treatment of this disease.
| Author | : Melvyn F. Greaves |
| Publisher | : |
| Total Pages | : 294 |
| Release | : 2001 |
| Genre | : Health & Fitness |
| ISBN | : 9780192628343 |
Every day, 1500 Americans die of cancer, and yet for most of us this deadly disease remains mysterious. Why is it so common? Why are there so many different causes? Why does treatment so often fail? What, ultimately, is cancer? In this fascinating new book, a leading cancer researcher offers general readers clear and convincing answers to these and many other questions. Mel Greaves places cancer in its evolutionary context, arguing that we can best answer the big questions about cancer by looking through a Darwinian lens. Drawing on both ancient and more modern evolutionary legacies, he shows how human development has changed the rules of evolutionary games, trapping us in a nature-nurture mismatch. Compelling examples, from the King of Naples intestinal tumor in the 15th century, through the epidemic of scrotal skin cancer in 18th-century chimney sweeps, to the current surge of cases of prostate cancer illustrate his thesis. He also shows why the old paradigms of infectious diseases or genetic disorders have proved fruitless when trying to explain this complex and elusive disease. And finally, he looks at the implications for research, prevention, and treatment of cancer that an evolutionary perspective provides. Drawing on the most recent research, this is the first book to put cancer in its evolutionary framework. At a time when Darwinian perspectives on everything from language acquisition to economics are providing new breakthroughs in understanding, medicine seems to have much to gain from the insights provided by evolutionary biology. Written in an exceptionally lucid and entertaining style, this book will be of broad interest to all those who wish to know more about this dread disease.
| Author | : Thomas Dittmar |
| Publisher | : CRC Press |
| Total Pages | : 330 |
| Release | : 2016-04-19 |
| Genre | : Medical |
| ISBN | : 1466577363 |
This book summarizes the latest findings about the role of cancer stem cells (CSCs) in cancer biology and how this knowledge could be used for novel anticancer therapies. It provides an overview of CSCs in selected malignancies with particular emphasis on hematopoietic neoplasias. It then reviews the role of CSCs in metastasis formation and initiat
