Cell Fate
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| Author | : |
| Publisher | : Academic Press |
| Total Pages | : 544 |
| Release | : 2019-05-24 |
| Genre | : Science |
| ISBN | : 0128148802 |
Epigenetics and Regeneration compiles the first foundational reference on epigenetic mechanisms governing tissue development, repair, homeostasis, and regeneration, as well as pathways to employ these mechanisms in clinical practice and translational science. In this book, life science researchers, clinicians, and students will discover an interdisciplinary resource bringing together common themes in the field, background overviews, research methods, recent advances, and opportunities for drug discovery. Throughout this volume, special attention is paid to pre-clinical and first clinical studies aimed at increasing the regenerative potential of damaged tissues by epigenetic drugs, as well as innovative, discipline spanning strategies to enhance cell reprogramming. As an all-inclusive, evidence-based volume, Epigenetics and Regeneration will stimulate discussion and boost new research in this fascinating and impactful area of translational epigenetics. - Provides a foundational overview of epigenetics in regenerative medicine - Examines epigenetic components of tissue regeneration for a variety of organ systems and tissue types, as well as current attempts to employ these mechanisms in clinical practice - Offers researchers, students, clinicians, and pharmacologists the tools they need to enhance tissue development, repair, homeostasis, and regeneration and explore new epigenetic therapeutic pathways - Features chapter contributions from leading international researchers and clinicians in the fields of epigenetics and regenerative medicine
| Author | : Stanley Fields |
| Publisher | : MIT Press |
| Total Pages | : 235 |
| Release | : 2010-09-24 |
| Genre | : Science |
| ISBN | : 0262289008 |
How tiny variations in our personal DNA can determine how we look, how we behave, how we get sick, and how we get well. News stories report almost daily on the remarkable progress scientists are making in unraveling the genetic basis of disease and behavior. Meanwhile, new technologies are rapidly reducing the cost of reading someone's personal DNA (all six billion letters of it). Within the next ten years, hospitals may present parents with their newborn's complete DNA code along with her footprints and APGAR score. In Genetic Twists of Fate, distinguished geneticists Stanley Fields and Mark Johnston help us make sense of the genetic revolution that is upon us. Fields and Johnston tell real life stories that hinge on the inheritance of one tiny change rather than another in an individual's DNA: a mother wrongly accused of poisoning her young son when the true killer was a genetic disorder; the screen siren who could no longer remember her lines because of Alzheimer's disease; and the president who was treated with rat poison to prevent another heart attack. In an engaging and accessible style, Fields and Johnston explain what our personal DNA code is, how a few differences in its long list of DNA letters makes each of us unique, and how that code influences our appearance, our behavior, and our risk for such common diseases as diabetes or cancer.
| Author | : |
| Publisher | : Academic Press |
| Total Pages | : 406 |
| Release | : 2018-02-21 |
| Genre | : Science |
| ISBN | : 0128043350 |
Cell Fate in Mammalian Development, Volume 128, the latest release in the Current Topics in Developmental Biology series, provides reviews on cell fate in mammalian development. Each chapter is written by an international board of authors, with this release including sections on the Specification of extra-embryonic lineages during mouse pre-implantation development, Cell polarity and fate specification, The circuitry that drives trophectoderm identity, Breaking symmetry and the dynamics of transcription factors directing cell fate specification, Mechanics and cell fate, How physical properties of cells change in development and their effect on cell fate decisions, and more. - Provides the authority and expertise of leading contributors from an international board of authors - Includes new sections on the specification of extra-embryonic lineages during mouse pre-implantation development, cell polarity and fate specification, the circuitry that drives trophectoderm identity, and more - Presents the latest release in the Current Topics in Developmental Biology series
| Author | : Herbert Levine |
| Publisher | : Academic Press |
| Total Pages | : 773 |
| Release | : 2020-06-10 |
| Genre | : Medical |
| ISBN | : 012817997X |
Phenotypic Switching: Implications in Biology and Medicine provides a comprehensive examination of phenotypic switching across biological systems, including underlying mechanisms, evolutionary significance, and its role in biomedical science. Contributions from international leaders discuss conceptual and theoretical aspects of phenotypic plasticity, its influence over biological development, differentiation, biodiversity, and potential applications in cancer therapy, regenerative medicine and stem cell therapy, among other treatments. Chapters discuss fundamental mechanisms of phenotypic switching, including transition states, cell fate decisions, epigenetic factors, stochasticity, protein-based inheritance, specific areas of human development and disease relevance, phenotypic plasticity in melanoma, prostate cancer, breast cancer, non-genetic heterogeneity in cancer, hepatitis C, and more. This book is essential for active researchers, basic and translational scientists, clinicians, postgraduates and students in genetics, human genomics, pathology, bioinformatics, developmental biology, evolutionary biology and adaptive opportunities in yeast. - Thoroughly addresses the conceptual, experimental and translational aspects that underlie phenotypic plasticity - Emphasizes quantitative approaches, nonlinear dynamics, mechanistic insights and key methodologies to advance phenotypic plasticity studies - Features a diverse range of chapter contributions from international leaders in the field
| Author | : |
| Publisher | : |
| Total Pages | : 0 |
| Release | : 2002 |
| Genre | : Cells |
| ISBN | : 9780815332183 |
| Author | : Ashley Moffett |
| Publisher | : |
| Total Pages | : 272 |
| Release | : 2006 |
| Genre | : Trophoblast |
| ISBN | : 9781107154209 |
This is the first dedicated, in-depth account of trophoblast: the tissue derived from the fertilized egg that nourishes and protects the developing fetus. Disorders of trophoblast during development manifest themselves in several clinical conditions during pregnancy, including gestational trophoblastic disease and pre-eclampsia.
| Author | : Chin-Hsing Annie Lin |
| Publisher | : Frontiers Media SA |
| Total Pages | : 104 |
| Release | : 2016-06-24 |
| Genre | : Genetics |
| ISBN | : 2889198529 |
The fundamental question of how an undifferentiated progenitor cell adopts a more specialized cell fate that then contributes to the development of specialized tissues, organs, organ systems and ultimately a unique individual of a given species has intrigued cell and developmental biologists for many years. Advances in molecular and cell biology have enabled investigators to identify genetic and epigenetic factors that contribute to these processes with increasing detail and also to define the various molecular characteristics of each cell fate with greater precision. Understanding these processes have also provided greater insights into disorders in which the normal mechanisms of cell fate determination are altered, such as in cancer and inherited malformations. With these advances have come techniques that facilitate the manipulation of cell fate, which have the potential to revolutionize the field of medicine by facilitating the repair and/or regeneration of diseased organs. Given the rapid advances that are occurring in the field, the articles in this eBook are both relevant and timely. These articles originally appeared online as part of the Research Topic “Cell Fate” overseen by my colleagues Dr. Lin, Dr. Buttitta, Dr. Maves, Dr. Dilworth, Dr. Paladini and myself and have been viewed extensively. Because of their popularity, they are now made available as an eBook, in a more easily downloadable form. Michael T. Chin
| Author | : C.H. Waddington |
| Publisher | : Routledge |
| Total Pages | : 231 |
| Release | : 2014-04-29 |
| Genre | : History |
| ISBN | : 1317657543 |
First published in 1957, this essential classic work bridged the gap between analytical and theoretical biology, thus setting the insights of the former in a context which more sensitively reflects the ambiguities surrounding many of its core concepts and objectives. Specifically, these five essays are concerned with some of the major problems of classical biology: the precise character of biological organisation, the processes which generate it, and the specifics of evolution. With regard to these issues, some thinkers suggest that biological organisms are not merely distinguishable from inanimate ‘things’ in terms of complexity, but are in fact radically different qualitatively: they exemplify some constitutive principle which is not elsewhere manifested. It is the desire to bring such ideas into conformity with our understanding of analytical biology which unifies these essays. They explore the contours of a conceptual framework sufficiently wide to embrace all aspects of living systems.
| Author | : Douglas W Houston |
| Publisher | : Academic Press |
| Total Pages | : 238 |
| Release | : 2017-11-14 |
| Genre | : Science |
| ISBN | : 0128125918 |
Cell Polarity in Development and Disease offers insights into the basic molecular mechanisms of common diseases that arise as a result of a loss of ordered organization and intrinsic polarity. Included are diseases affecting highly polarized epithelial tissues in the lung and kidney, as well as loss and gain of cell polarity in the onset and progression of cancer. This book provides a basic resource for understanding the biology of polarity, offering a starting point for those thinking of targeting cell polarity for translational medical research. - Provides basic science understanding of cell polarity disease and development - Covers diseases affecting polarized epithelial tissues in the lung and kidney, also covering the progression of cancer - Includes historical context of cell polarity research for potential future breakthroughs
| Author | : Leon W. Browder |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 448 |
| Release | : 2012-12-06 |
| Genre | : Science |
| ISBN | : 146156817X |
This series was established to create comprehensive treatises on specific topics in developmental biology. Such volumes serve a useful role in developmental biology, which is a very diverse field that receives contributions from a wide variety of disciplines. This series is a meeting ground for the various practi tioners of this science, facilitating an integration of heterogeneous information on specific topics. Each volume is comprised of chapters selected to provide the conceptual basis for a comprehensive understanding of its topic as well as an analysis of the key experiments upon which that understanding is based. The specialist in any aspect of developmental biology should understand the experimental back ground of the specialty and be able to place that body of information in context, in order to ascertain where additional research would be fruitful. The creative process then generates new experiments. This series is intended to be a vital link in that ongoing process of learning and discovery.
