Caveolae And Lipid Rafts Roles In Signal Transduction And The Pathogenesis Of Human Disease
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Author | : Edward Bittar |
Publisher | : Elsevier |
Total Pages | : 269 |
Release | : 2005-10-07 |
Genre | : Science |
ISBN | : 0080458602 |
Caveolae (latin for little caves) are small structures found at the surface of cells. They are responsible for the regulation of important metabolic pathway. As a consequence, they may play a critical role in several human diseases such as atherosclerosis, cancer, diabetes, and muscular dystrophies. This book analyzes the role and function of caveolae in these aspects and serves as the first textbook currently available on caveolae/caveolin.
Author | : Mark P. Mattson |
Publisher | : Springer Science & Business Media |
Total Pages | : 219 |
Release | : 2007-10-27 |
Genre | : Science |
ISBN | : 159259803X |
Cutting-edge articles review our current understanding of lipid microdomain signaling mechanisms and their physiological and pathological importance. The book describes the role of lipid rafts in learning, memory, and cancer, presents the emerging evidence that lipid rafts play critical roles in signaling pathways and the regulation of synaptic function in the nervous system, and shows how alterations in lipid raft metabolism are implicated in the pathogenesis of neurodegenerative disorders. Techniques are also described for the isolation of lipid rafts, the analysis of the lipid and protein components of lipid rafts, the imaging of lipid rafts in living cells, and the analysis of signal transduction in lipid rafts.
Author | : Christopher J. Fielding |
Publisher | : John Wiley & Sons |
Total Pages | : 294 |
Release | : 2006-12-13 |
Genre | : Science |
ISBN | : 3527607501 |
This keenly awaited first overview of the field represents a complete guide to the structure and function of the most important mammalian cell membrane organelles. Filling a huge gap in the primary literature, this book is the first to cover the subject in detail. Following an introduction by Kai Simons, the discoverer of lipid rafts and the most prominent scientist in the field, chapters include: Historical background Distinct structures and functions Structural basis Signaling Viral entry and virion budding Cholesterol transport Caveolins Lipid shells Cell polarity and intracellular trafficking Cancer cells Of prime importance to molecular and cell biologists, biochemists, membrane scientists, cancer researchers, and virologists.
Author | : Edward Bittar |
Publisher | : Elsevier Science |
Total Pages | : 270 |
Release | : 1992 |
Genre | : Science |
ISBN | : 9781559382090 |
The fourth volume of the Advances in Molecular and Cell Biology series. Cell biology is a rapidly-developing discipline, bringing together many separate biological sciences. The interrelations of cell structure and function at molecular and subcellular levels are the central theme of the series.
Author | : Lawrence W. Miller |
Publisher | : John Wiley & Sons |
Total Pages | : 204 |
Release | : 2008-09-02 |
Genre | : Science |
ISBN | : 9783527315666 |
The only resource to systematically review current experimental methods, this handy reference enables researchers to select the best solution for their experimental problems. For each method covered, the book provides step-by-step protocols, illustrated by typical research applications. After an initial section on probing the lipid bilayer, the text moves on to discuss probing proteins -- including membrane proteins -- and nucleic acids. The first single publication to incorporate chemical markers, fluorescent probes and genetic tags allows a well-informed comparison of different solutions for the same problem in molecular analytics.
Author | : J. Robin Harris |
Publisher | : Springer Science & Business Media |
Total Pages | : 641 |
Release | : 2010-03-10 |
Genre | : Science |
ISBN | : 9048186226 |
Knowledge of cholesterol and its interaction with protein molecules is of fundamental importance in both animal and human biology. This book contains 22 chapters, dealing in depth with structural and functional aspects of the currently known and extremely diverse unrelated families of cholesterol-binding and cholesterol transport proteins. By drawing together this range of topics the Editor has attempted to correlate this broad field of study for the first time. Technical aspects are given considerable emphasis, particularly in relation cholesterol reporter molecules and to the isolation and study of membrane cholesterol- and sphingomyelin-rich "raft" domains. Cell biological, biochemical and clinical topics are included in this book, which serve to emphasize the acknowledged and important benefits to be gained from the study of cholesterol and cholesterol-binding proteins within the biomedical sciences and the involvement of cholesterol in several clinical disorders. It is hoped that by presenting this topic in this integrated manner that an appreciation of the fact that there is much more that needs to be taken into account, studied and understood than the widely discussed "bad and good cholesterol" associated, respectively, with the low- and high-density lipoproteins, LDL and HDL.
Author | : Cai Huang |
Publisher | : BoD – Books on Demand |
Total Pages | : 482 |
Release | : 2012-09-06 |
Genre | : Medical |
ISBN | : 9535107372 |
15 chapters on protein phosphorylation and human health written by expert scientists. Covers most important research hot points, such as Akt, AMPK and mTOR. Bridges the basic protein phosphorylation pathways with human health and diseases. Detailed and comprehensive text with excellent figure illustration.
Author | : Arnold von Eckardstein |
Publisher | : Springer |
Total Pages | : 0 |
Release | : 2015-01-13 |
Genre | : Medical |
ISBN | : 9783319096643 |
In this Handbook of Experimental Pharmacology on “High Density Lipoproteins – from biological understanding to clinical exploitation” contributing authors (members of COST Action BM0904/HDLnet) summarize in more than 20 chapters our current knowledge on the structure, function, metabolism and regulation of HDL in health and several diseases as well as the status of past and ongoing attempts of therapeutic exploitation. The book is of interest to researchers in academia and industry focusing on lipoprotein metabolism, cardiovascular diseases and immunology as well as clinical pharmacologists, cardiologists, diabetologists, nephrologists and other clinicians interested in metabolic or inflammatory diseases.
Author | : Stavros J. Baloyannis |
Publisher | : |
Total Pages | : 0 |
Release | : 2021 |
Genre | : Brain |
ISBN | : 9781839680984 |
Cerebral and Cerebellar Cortex - Interaction and Dynamics in Health and Disease discusses several important issues of cerebro-cerebellar collaboration and interactions. The morphological and functional study of the cerebral and cerebellar cortices and their interaction has considerable value for interpreting the clinical phenomenology of cortical degenerations in the initial stage of the disease. In addition, the analysis of cerebro-cerebellar interactions strongly supports the concept of the close functional unity and harmonization of the brain and the cerebellum, underlining the important role that the cerebellar cortex plays in the performance of higher mental faculties, creativity, emotional processes, and homeostatic equilibrium of the human body.
Author | : Daniel G.S. Capelluto |
Publisher | : Springer Science & Business Media |
Total Pages | : 227 |
Release | : 2013-06-17 |
Genre | : Medical |
ISBN | : 940076331X |
This book provides the most updated information of how membrane lipids mediate protein signaling from studies carried out in animal and plant cells. Also, there are some chapters that go beyond and expand these studies of protein-lipid interactions at the structural level. The book begins with a literature review from investigations associated to sphingolipids, followed by studies that describe the role of phosphoinositides in signaling and closing with the function of other key lipids in signaling at the plasma membrane and intracellular organelles.