Care, Use, and Welfare of Marmosets as Animal Models for Gene Editing-Based Biomedical Research

Care, Use, and Welfare of Marmosets as Animal Models for Gene Editing-Based Biomedical Research
Author: National Academies of Sciences, Engineering, and Medicine
Publisher: National Academies Press
Total Pages: 123
Release: 2019-08-26
Genre: Science
ISBN: 0309488516

The marmoset, a type of small monkey native to South America, is a research model of increasing importance for biomedical research in the United States and globally. Marmosets offer a range of advantages as animal models in neuroscience, aging, infectious diseases, and other fields of study. They may be particularly useful for the development of new disease models using genetic engineering and assisted reproductive technologies. However, concerns have been voiced with respect to the development of new marmoset-based models of disease, ethical considerations for their use, the supply of marmosets available for research, and gaps in guidance for their care and management. To explore and address these concerns, the Roundtable on Science and Welfare in Laboratory Animal Use hosted a public workshop on October 22-23, 2018, in Washington, DC. The workshop focused on the availability of marmosets in the United States and abroad; animal welfare and ethical considerations stemming from the use of wildtype and genetically modified marmosets; and standards of housing and care, dietary needs, and feeding requirements for marmosets in captivity. This publication summarizes the presentations and discussions from the workshop.

Care, Use, and Welfare of Marmosets As Animal Models for Gene Editing-Based Biomedical Research

Care, Use, and Welfare of Marmosets As Animal Models for Gene Editing-Based Biomedical Research
Author: Engineering National Academies of Sciences (and Medicine)
Publisher:
Total Pages: 107
Release: 2019
Genre: Gene editing
ISBN: 9780309488525

"The marmoset, a type of small monkey native to South America, is a research model of increasing importance for biomedical research in the United States and globally. Marmosets offer a range of advantages as animal models in neuroscience, aging, infectious diseases, and other fields of study. They may be particularly useful for the development of new disease models using genetic engineering and assisted reproductive technologies. However, concerns have been voiced with respect to the development of new marmoset-based models of disease, ethical considerations for their use, the supply of marmosets available for research, and gaps in guidance for their care and management. To explore and address these concerns, the Roundtable on Science and Welfare in Laboratory Animal Use hosted a public workshop on October 22-23, 2018, in Washington, DC. The workshop focused on the availability of marmosets in the United States and abroad; animal welfare and ethical considerations stemming from the use of wildtype and genetically modified marmosets; and standards of housing and care, dietary needs, and feeding requirements for marmosets in captivity. This publication summarizes the presentations and discussions from the workshop"--Publisher's description

Genome Editing in Neurosciences

Genome Editing in Neurosciences
Author: Rudolf Jaenisch
Publisher:
Total Pages: 128
Release: 2020-10-08
Genre: Medical
ISBN: 9781013268564

Innovations in molecular biology are allowing neuroscientists to study the brain with unprecedented resolution, from the level of single molecules to integrated gene circuits. Chief among these innovations is the CRISPR-Cas genome editing technology, which has the precision and scalability to tackle the complexity of the brain. This Colloque Médecine et Recherche has brought together experts from around the world that are applying genome editing to address important challenges in neuroscience, including basic biology in model organisms that has the power to reveal systems-level insight into how the nervous system develops and functions as well as research focused on understanding and treating human neurological disorders. This work was published by Saint Philip Street Press pursuant to a Creative Commons license permitting commercial use. All rights not granted by the work's license are retained by the author or authors.

Management of Animal Care and Use Programs in Research, Education, and Testing

Management of Animal Care and Use Programs in Research, Education, and Testing
Author: Robert H. Weichbrod
Publisher: CRC Press
Total Pages: 917
Release: 2017-09-07
Genre: Medical
ISBN: 1498748457

AAP Prose Award Finalist 2018/19 Management of Animal Care and Use Programs in Research, Education, and Testing, Second Edition is the extensively expanded revision of the popular Management of Laboratory Animal Care and Use Programs book published earlier this century. Following in the footsteps of the first edition, this revision serves as a first line management resource, providing for strong advocacy for advancing quality animal welfare and science worldwide, and continues as a valuable seminal reference for those engaged in all types of programs involving animal care and use. The new edition has more than doubled the number of chapters in the original volume to present a more comprehensive overview of the current breadth and depth of the field with applicability to an international audience. Readers are provided with the latest information and resource and reference material from authors who are noted experts in their field. The book: - Emphasizes the importance of developing a collaborative culture of care within an animal care and use program and provides information about how behavioral management through animal training can play an integral role in a veterinary health program - Provides a new section on Environment and Housing, containing chapters that focus on management considerations of housing and enrichment delineated by species - Expands coverage of regulatory oversight and compliance, assessment, and assurance issues and processes, including a greater discussion of globalization and harmonizing cultural and regulatory issues - Includes more in-depth treatment throughout the book of critical topics in program management, physical plant, animal health, and husbandry. Biomedical research using animals requires administrators and managers who are knowledgeable and highly skilled. They must adapt to the complexity of rapidly-changing technologies, balance research goals with a thorough understanding of regulatory requirements and guidelines, and know how to work with a multi-generational, multi-cultural workforce. This book is the ideal resource for these professionals. It also serves as an indispensable resource text for certification exams and credentialing boards for a multitude of professional societies Co-publishers on the second edition are: ACLAM (American College of Laboratory Animal Medicine); ECLAM (European College of Laboratory Animal Medicine); IACLAM (International Colleges of Laboratory Animal Medicine); JCLAM (Japanese College of Laboratory Animal Medicine); KCLAM (Korean College of Laboratory Animal Medicine); CALAS (Canadian Association of Laboratory Animal Medicine); LAMA (Laboratory Animal Management Association); and IAT (Institute of Animal Technology).

Viral Pathogenesis

Viral Pathogenesis
Author: Michael G. Katze
Publisher: Academic Press
Total Pages: 368
Release: 2015-12-30
Genre: Medical
ISBN: 0128011742

Viral Pathogenesis: From Basics to Systems Biology, Third Edition, has been thoroughly updated to cover topical advances in the evolving field of viral pathogenesis, while also providing the requisite classic foundational information for which it is recognized. The book provides key coverage of the newfound ability to profile molecular events on a system-wide scale, which has led to a deeper understanding of virus-host interactions, host signaling and molecular-interaction networks, and the role of host genetics in determining disease outcome. In addition, the content has been augmented with short chapters on seminal breakthroughs and profiles of their progenitors, as well as short commentaries on important or controversial issues in the field. Thus, the reader will be given a view of virology research with perspectives on issues such as biomedical ethics, public health policy, and human health. In summary, the third edition will give the student a sense of the exciting new perspectives on viral pathogenesis that have been provided by recent developments in genomics, computation, modeling, and systems biology. - Covers all aspects of viral infection, including viral entry, replication, and release, as well as innate and adaptive immunity and viral pathogenesis - Provides a fresh perspective on the approaches used to understand how viruses cause disease - Features molecular profiling techniques, whole genome sequencing, and innovative computational methods - Highlights the use of contemporary approaches and the insights they provide to the field

Animal Experimentation

Animal Experimentation
Author: Kathrin Herrmann
Publisher:
Total Pages: 0
Release: 2019
Genre: Animal experimentation
ISBN: 9789004356184

Animal Experimentation: Working Towards a Paradigm Change critically appraises current animal use in science and discusses ways in which we can contribute to a paradigm change towards human-biology based approaches.

Occupational Health and Safety in the Care and Use of Research Animals

Occupational Health and Safety in the Care and Use of Research Animals
Author: Committee on Occupational Safety and Health in Research Animal Facilities
Publisher: National Academies Press
Total Pages: 167
Release: 1997-06-23
Genre: Business & Economics
ISBN: 0309520398

Much has been written about the care of research animals. Yet little guidance has appeared on protecting the health and safety of the people who care for or use these animals. This book, an implementation handbook and companion to Guide For the Care and Use of Laboratory Animals, identifies principles for building a program and discusses the accountability of institutional leaders, managers, and employees for a program's success. It provides a detailed description of risks-- physical and chemical hazards, allergens and zoonoses, and hazards from experiments--which will serve as a continuing reference for the laboratory. The book offers specific recommendations for controlling risk through administrative procedures, facility design, engineering controls, and periodic evaluations. The volume focuses on the worker, with detailed discussions of work practices, the use of personal protective gear, and the development of an emergency response plan. This handbook will be invaluable to administrators, researchers, and employees in any animal research facility. It will also be of interest to personnel in zoos, animal shelters, and veterinary facilities.

The Oxford Handbook of Practical Ethics

The Oxford Handbook of Practical Ethics
Author: Hugh LaFollette
Publisher: Oxford Handbooks Online
Total Pages: 796
Release: 2005-09-15
Genre: Law
ISBN: 9780199284238

This is a guide to contemporary thought on ethical issues in all areas of human activity - personal, medical, sexual, social, political, judicial, and international, from the natural world to the world of business.

Handbook of Primate Husbandry and Welfare

Handbook of Primate Husbandry and Welfare
Author: Sarah Wolfensohn
Publisher: John Wiley & Sons
Total Pages: 176
Release: 2008-04-15
Genre: Medical
ISBN: 1405156155

Handbook of Primate Husbandry and Welfare covers all aspects of primate care and management both in the laboratory environment and in zoos. From the welfare and ethics of primate captivity through to housing and husbandry systems, environmental enrichment, nutritional requirements, breeding issues, primate diseases, and additional information on transportation and quarantine proceedings, this book provides a completely comprehensive guide to good husbandry and management of primates. Designed to be a practical field manual, the authors present the material using lists, tables and illustrations to clarify best practice. Representative species are covered – from marmosets through to macaques One of the first books dedicated to the care of primates in captivity Written by authors with many years of experience working with primates Suitable for those working with primates in either laboratories or zoos