Heart Regeneration
| Author | : Felix B. Engel |
| Publisher | : World Scientific |
| Total Pages | : 393 |
| Release | : 2012 |
| Genre | : Medical |
| ISBN | : 9814299804 |
This title presents the major advances of the last decade in the field of cardiac regeneration.
Cardiac Regeneration
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Cardiac Regeneration
| Author | : Masaki Ieda |
| Publisher | : Springer |
| Total Pages | : 274 |
| Release | : 2017-10-27 |
| Genre | : Medical |
| ISBN | : 3319561065 |
This Volume of the series Cardiac and Vascular Biology offers a comprehensive and exciting, state-of-the-art work on the current options and potentials of cardiac regeneration and repair. Several techniques and approaches have been developed for heart failure repair: direct injection of cells, programming of scar tissue into functional myocardium, and tissue-engineered heart muscle support. The book introduces the rationale for these different approaches in cell-based heart regeneration and discusses the most important considerations for clinical translation. Expert authors discuss when, why, and how heart muscle can be salvaged. The book represents a valuable resource for stem cell researchers, cardiologists, bioengineers, and biomedical scientists studying cardiac function and regeneration.
Cardiac Regeneration and Repair
| Author | : Ren-Ke Li |
| Publisher | : Elsevier |
| Total Pages | : 509 |
| Release | : 2014-02-17 |
| Genre | : Science |
| ISBN | : 0857096710 |
Cardiac Regeneration and Repair, Volume Two reviews the use of biomaterials, alone or combined with cell therapy, in providing tissue-engineered constructs to repair the injured heart and prevent or reverse heart failure. Part one explores the variety of biomaterials available for cardiac repair, including nanomaterials and hydrogels. Further chapters explore the use of biomaterials to enhance stem cell therapy for restoring ventricular function and generating stem cell-modified intravascular stents. Part two focuses on tissue engineering for cardiac repair, including chapters on decellularized biologic scaffolds, synthetic scaffolds, cell sheet engineering, maturation of functional cardiac tissue patches, vascularized engineered tissues for in vivo and in vitro applications, and clinical considerations for cardiac tissue engineering. Finally, part three explores vascular remodeling, including chapters highlighting aortic extracellular matrix remodeling, cell-biomaterial interactions for blood vessel formation, and stem cells for tissue-engineered blood vessels. Cardiac Regeneration and Repair, Volume Two is complemented by an initial volume covering pathology and therapies. Together, the two volumes of Cardiac Regeneration and Repair provide a comprehensive resource for clinicians, scientists, or academicians fascinated with cardiac regeneration, including those interested in cell therapy, tissue engineering, or biomaterials. Surveys the variety of biomaterials available for cardiac repair, including nanomaterials and hydrogels. Focuses on tissue engineering for cardiac repair including clinical considerations for cardiac tissue engineering Explores vascular remodeling, highlighting aortic extracellular matrix remodeling, cell-biomaterial interactions for blood vessel formation, and stem cells for tissue-engineered blood vessels
Heart Regeneration: Stem Cells And Beyond
| Author | : Felix B Engel |
| Publisher | : World Scientific |
| Total Pages | : 393 |
| Release | : 2012-03-22 |
| Genre | : Medical |
| ISBN | : 9814465259 |
Injured mammalian hearts do not regenerate but scar. This is a major medical problem, as ischemic heart disease is among the leading causes of morbidity and mortality worldwide. Essential clues for human heart repair are uncovered when zebrafish and newt are found to regenerate cardiac muscle after injury.This book presents the major advances of the last decade in the field of cardiac regeneration. These recent advances include: demonstration that zebrafish, a genetically tractable system, can regenerate heart; the identification of several new stem cell populations in the heart; demonstration that stem cells can be used to improve heart function; and demonstration that induction of cardiomyocyte proliferation is a realistic future option to repair injured hearts. This book also provides detailed reviews of the research on model organisms capable of heart regeneration as well as innovative translational research to achieve regeneration in mammals, that comprises work on blood born stem cells, endogenous cardiac stem cells, paracrine factors, reawakening of cardiomyocyte proliferation, and bioengineering. More importantly, the book, in the concluding chapter, dovetails the studies with a comprehensive overview of clinical trials.
Cardiac Regeneration and Repair
| Author | : Ren-Ke Li |
| Publisher | : Elsevier |
| Total Pages | : 459 |
| Release | : 2014-02-16 |
| Genre | : Science |
| ISBN | : 0857096702 |
Cardiac Regeneration and Repair, Volume One reviews the pathology of cardiac injury and the latest advances in cell therapy. Chapters in part one explore the pathogenesis of congestive heart failure, the mechanisms responsible for adverse cardiac matrix remodeling, and potential interventions to restore ventricular function. Part two highlights new approaches to cell therapy for cardiac regeneration, and includes chapters covering alternative routes of cell delivery, monitoring cell engraftment, and the feasibility of using allogeneic stem cells to restore cardiac function. Chapters in part three move on to highlight novel stem cells for cardiac repair, including human embryonic stem cells and human pluripotent stem cells, and detail their current status and future potential for cardiac therapy. Finally, part four explores gene therapy, and includes ultrasound-targeted or direct gene delivery as well as cell-based gene therapy for cardiac regeneration. Cardiac Regeneration and Repair, Volume One is complemented by a second volume covering biomaterials and tissue engineering. Together, the two volumes of Cardiac Regeneration and Repair provide a comprehensive resource for clinicians, scientists, or academicians fascinated with cardiac regeneration, including those interested in cell therapy, tissue engineering, or biomaterials. Explores the pathogenesis of congestive heart failure, the mechanisms responsible for adverse cardiac matrix remodeling, and potential interventions to restore ventricular function Highlights new approaches to cell therapy for cardiac regeneration and includes chapters covering alternative routes of cell delivery, monitoring cell engraftment, and the feasibility of using allogeneic stem cells to restore cardiac function Explores gene therapy and includes ultrasound-targeted or direct gene delivery as well as cell-based gene therapy for cardiac regeneration
Stem Cells and Cardiac Regeneration
| Author | : Rosalinda Madonna |
| Publisher | : Springer |
| Total Pages | : 219 |
| Release | : 2015-12-18 |
| Genre | : Science |
| ISBN | : 3319254278 |
This book provides an update of recent advances in the basic and clinical applications of cell-based therapies for myocardial repair and regeneration in ischemic heart disease (IHD) and heart failure (HF). The first sections of the book illuminate basic aspects of stem cells such as definitions, isolation criteria and characterization of embryonic and adult stem cells, as well as pluripotent stem cells and tissue specific progenitor and stem cells. In the following section, the text examines the role of critical regulators of stem cell differentiation in myocardial regeneration, that include circadian rhythyms, microRNAs, epigenetics, microvescicles, and exosomes. The text concludes with a review of the use of stem/progenitor cells in cardiac regeneration and discuss current controversies, unresolved issues, challenges, and future directions. Stem Cells and Cardiac Regeneration is addressed to a wide audience consisting of cardiologists, clinicians, and research scientists, who will learn new concepts in cardiovascular regeneration and repair with special focus on molecular mechanisms and therapeutic potential for cardiovascular regeneration.
Advanced Therapies for Cardiac Regeneration
| Author | : Valeria Chiono |
| Publisher | : Frontiers Media SA |
| Total Pages | : 324 |
| Release | : 2021-04-13 |
| Genre | : Science |
| ISBN | : 2889666956 |
The Research Topic is organized in the framework of the project BIORECAR (grant number: 772168; http://www.biorecar.polito.it/index.html)
Cardiac Regeneration
| Author | : Kenneth Poss |
| Publisher | : Humana |
| Total Pages | : 344 |
| Release | : 2020-11-06 |
| Genre | : Science |
| ISBN | : 9781071606674 |
This detailed book addresses major goals of regenerative medicine and the cardiovascular research community with techniques to replenish lost cardiomyocytes, avoid scar-associated pathology, and improve myocardial infarction (MI) outcomes. The collection begins with a section on cardiac injury models, including zebrafish, neonatal and adult mice, and pigs, and continues with sections covering culturing cardiomyocytes from different species as well as methods for labeling or manipulation of cardiac tissue for the purpose of answering questions in regeneration. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Cardiac Regeneration: Methods and Protocols provides the latest models and methods used in the field of heart regeneration, designed for researchers interested in establishing these assays in their laboratories to reproduce or extend findings, and for familiarizing themselves with the field if it is new to them.
Heart Development and Regeneration
| Author | : Nadia Rosenthal |
| Publisher | : Academic Press |
| Total Pages | : 1126 |
| Release | : 2010-05-28 |
| Genre | : Science |
| ISBN | : 0123813336 |
The development of the cardiovascular system is a rapidly advancing area in biomedical research, now coupled with the burgeoning field of cardiac regenerative medicine. A lucid understanding of these fields is paramount to reducing human cardiovascular diseases of both fetal and adult origin. Significant progress can now be made through a comprehensive investigation of embryonic development and its genetic control circuitry. Heart Development and Regeneration, written by experts in the field, provides essential information on topics ranging from the evolution and lineage origins of the developing cardiovascular system to cardiac regenerative medicine. A reference for clinicians, medical researchers, students, and teachers, this publication offers broad coverage of the most recent advances. Volume One discusses heart evolution, contributing cell lineages; model systems; cardiac growth; morphology and asymmetry; heart patterning; epicardial, vascular, and lymphatic development; and congenital heart diseases. Volume Two includes chapters on transcription factors and transcriptional control circuits in cardiac development and disease; epigenetic modifiers including microRNAs, genome-wide mutagenesis, imaging, and proteomics approaches; and the theory and practice of stem cells and cardiac regeneration. Authored by world experts in heart development and disease New research on epigenetic modifiers in cardiac development Comprehensive coverage of stem cells and prospects for cardiac regeneration Up-to-date research on transcriptional and proteomic circuits in cardiac disease Full-color, detailed illustrations
Cardiovascular Regeneration and Stem Cell Therapy
| Author | : Annarosa Leri |
| Publisher | : John Wiley & Sons |
| Total Pages | : 248 |
| Release | : 2008-04-15 |
| Genre | : Medical |
| ISBN | : 0470994304 |
This book is the definitive reference on two of the most exciting areas of cardiovascular research – myocardial regeneration and stem cell therapy – for the treatment of disease. Edited by pioneers in the area, with contributions from every major investigator worldwide, it covers: The biology of stem cells The actions of stem cells from the bone marrow, the heart, and embryos on the normal restorative and repair functions of the heart and blood vessels How stem cells could contribute to myocardial recovery in the face of injury and aging How adjuvant therapy with growth factors might enhance stem cell activity in regeneration and repair Clinical applications and clinical experiences This fully referenced publication presents the current state of knowledge in both basic science and clinical practice, and is an essential reference for scientists, students, and clinicians.
