Cardiac Energetics
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| Author | : R. Jacob |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 410 |
| Release | : 2013-04-17 |
| Genre | : Medical |
| ISBN | : 3662112892 |
Assessment of cardiac energetics at the level of ATP-synthesis, chemomechanical energy transformation and whole organ dynamics as a function of haemodynamic load, ventricular configuration and oxygen- and substrates supply is basic to understanding cardiac function under physiological and pathophysiological (hypertrophy, hypoxia, ischaemia and heart failure) conditions. Moreover, cardiac energetics should be an important consideration in the choice and application of drugs especially in the case of vasodilators, inotropic agents and in cardioprotective measures. Only by considering energetics at the subcellular, cellular, and whole-heart level we can arrive at a better understanding of cardiac performance and ultimately better clinical judgement and drug therapy. Quantification of myocardial energetics will also help to determine the optimal time for surgical interventions such as valvular replacement or aneurysm resection. The present volume is the outcome of an international symposium on cardiac energetics held in Gargellen/Montafon (Austria), June 1986. The contributions will certainly help bridge the existing gap between basic research involving isolated structures and that involving the whole organ, on the one hand, and render the results derived from basic research applicable to clinical problems, on the other hand.
| Author | : Gary D. Lopaschuk |
| Publisher | : Springer |
| Total Pages | : 301 |
| Release | : 2014-08-22 |
| Genre | : Science |
| ISBN | : 1493912275 |
The heart has a very high energy demand but very little energy reserves. In order to sustain contractile function, the heart has to continually produce a large amount of ATP. The heart utilizes free fatty acids mainly and carbohydrates to some extent as substrates for making energy and any change in this energy supply can seriously compromise cardiac function. It has emerged that alterations in cardiac energy metabolism are a major contributor to the development of a number of different forms of heart disease. It is also now known that optimizing energy metabolism in the heart is a viable and important approach to treating various forms of heart disease. Cardiac Energy Metabolism in Health and Disease describes the research advances that have been made in understanding what controls cardiac energy metabolism at molecular, transcriptional and physiological levels. It also describes how alterations in energy metabolism contribute to the development of heart dysfunction and how optimization of energy metabolism can be used to treat heart disease. The topics covered include a discussion of the effects of myocardial ischemia, diabetes, obesity, hypertrophy, heart failure, and genetic disorders of mitochondrial oxidative metabolism on cardiac energetics. The treatment of heart disease by optimizing energy metabolism is also discussed, which includes increasing overall energy production as well as increasing the efficiency of energy production and switching energy substrate preference of the heart. This book will be a valuable source of information to graduate students, postdoctoral fellows, and investigators in the field of experimental cardiology as well as biochemists, physiologists, pharmacologists, cardiologists, cardiovascular surgeons and other health professionals.
| Author | : Andrew L. Clark |
| Publisher | : Oxford University Press |
| Total Pages | : 897 |
| Release | : 2022 |
| Genre | : Medical |
| ISBN | : 019876622X |
Taking the reader from an understanding of the basic mechanisms of heart failure through to an appreciation of the complexities of heart failure management and the remarkable improvements possible with good treatment, the Oxford Textbook of Heart Failure 2e covers all aspects necessary to manage a patient with heart failure. In full colour throughout, containing over 300 illustrations, and supported by detailed referencing from the huge evidence base that has developed over the last two decades, the textbook also includes extensive chapters on common co-morbidities. The new edition has been completely updated in line with new British and European Guidelines and contains new chapters on; Natriuretic Peptides and Novel Biomarkers in Heart Failure, The Future of Heart Failure, and Regenerative Therapies. Essential reading for consultant cardiologists and those in training, general physicians and those caring of the elderly, cardiothoracic surgeons, primary care doctors, pharmacists, and specialist nurses.
| Author | : Volkmar Weissig |
| Publisher | : Humana |
| Total Pages | : 468 |
| Release | : 2021-06-03 |
| Genre | : Medical |
| ISBN | : 9781071612699 |
This second edition offers 88 chapters divided among three volumes providing the most comprehensive source of know-how in the wide-ranging field of Mitochondrial Medicine. Volume III guides readers through chapters on intercellular mitochondrial transfer, Cytoplasmic transfer methods, Ndufs4 knockout mouse, in vivo assessment of mitochondrial oxygen consumption, mitochondrial network analysis by imaging, mitochondrial respiration in platelets, Heterologous Inferential Analysis (HIA), bioenergetic profiling, integrative methods for studying cardiac energetics, and isolation and deep sequencing of mitochondrial DNA.Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, application details for both the expert and non-expert reader, and tips on troubleshooting and avoiding known pitfalls. Authoritative and accessible, Mitochondrial Medicine, Second Edition, Volume 3: Manipulating Mitochondria and Disease- Specific Approaches aims to be a comprehensive source of know-how in the wide-ranging field of Mitochondrial Medicine.
| Author | : Michael Schwarzer |
| Publisher | : Academic Press |
| Total Pages | : 241 |
| Release | : 2015-11-04 |
| Genre | : Science |
| ISBN | : 0128026146 |
The Scientists Guide to Cardiac Metabolism combines the basic concepts of substrate metabolism, regulation, and interaction within the cell and the organism to provide a comprehensive introduction into the basics of cardiac metabolism. This important reference is the perfect tool for newcomers in cardiac metabolism, providing a basic understanding of the metabolic processes and enabling the newcomer to immediately communicate with the expert as substrate/energy metabolism becomes part of projects. The book is written by established experts in the field, bringing together all the concepts of cardiac metabolism, its regulation, and the impact of disease. - Provides a quick and comprehensive introduction into cardiac metabolism - Contains an integrated view on cardiac metabolism and its interrelation in metabolism with other organs - Presents insights into substrate metabolism in relation to intracellular organization and structure as well as whole organ function - Includes historical perspectives that reference important investigators that have contributed to the development of the field
| Author | : Albert Dahan |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 230 |
| Release | : 2011-06-27 |
| Genre | : Medical |
| ISBN | : 9401151296 |
On 15 November 1997, the first international symposium "Neural and Chemical Control of Breathing: Pharmacological and Clinical Aspects" was held at Leiden University Medical Center on the occasion of the retirement of one of the members of the Control of Breathing Research Group of the Departments of Physiology and Anesthesiology, Dr. Aad Berkenbosch. Among others, Dr. Berkenbosch, played an important role in this research group, which made a large and significant contribution to scientific research on the regulation of breathing. This book presents the proceedings of that meeting together with papers of several authors who have strong bonds with the Leiden Departments of Physiology and Anesthesiology. All studies represent state of the art work on the subject of respiratory control and cardiovascular medicine, with emphasis on the physiological, pharmacological and anesthesiological aspects of both fields. The book is divided in several sections: Oxygen Physiology. Prof. John Severinghaus presents among other things his ideas on oxygen sensing and high altitude related diseases. Prof. Honda gives results from studies in a unique set of subjects without carotid bodies. The findings of Honda's group support the idea that an intact hypoxic drive from the carotid bodies is necessary for the generation of central hypoxic depression. Dr. Hans van Beek discusses the effects of hypoxia and hypercapnia on cardiac contractility in animal models. Prof. Oeseburg demonstrates the feasibility of Near Infra Red Oximetry for monitoring tissue oxygenation in patients. Central Chemoreception.
| Author | : Paul P. Pearsall |
| Publisher | : Harmony |
| Total Pages | : 440 |
| Release | : 1999-03-10 |
| Genre | : Health & Fitness |
| ISBN | : 0767999428 |
A fascinating synthesis of ancient wisdom, modern medicine, scientific research, and personal experiences that proves that the human heart, not the brain, holds the secrets that link body, mind, and spirit. You know that the heart loves and feels, but did you know that the heart also thinks, remembers, communicates with other hearts, helps regulate immunity, and contains stored information that continually pulses through your body? In The Heart's Code, Dr. Paul Pearsall explains the theory and science behind energy cardiology, the emerging field that is uncovering one of the most significant medical, social, and spiritual discoveries of our time: The heart is more than just a pump; it conducts the cellular symphony that is the very essence of our being. Full of amazing anecdotes and data, The Heart's Code presents the latest research on cellular memory and the power of the heart's energy and explores what these breakthroughs mean about how we should live our lives. By unlocking the heart's code we can discover new ways of understanding human healing and consciousness and create a new model for living that leads to better health, happiness, and self-knowledge.
| Author | : Euan A. Ashley |
| Publisher | : Remedica |
| Total Pages | : 258 |
| Release | : 2004 |
| Genre | : Cardiology |
| ISBN | : 1901346226 |
One of the most time-consuming tasks in clinical medicine is seeking the opinions of specialist colleagues. There is a pressure not only to make referrals appropriate but also to summarize the case in the language of the specialist. This book explains basic physiologic and pathophysiologic mechanisms of cardiovascular disease in a straightforward manner, gives guidelines as to when referral is appropriate, and, uniquely, explains what the specialist is likely to do. It is ideal for any hospital doctor, generalist, or even senior medical student who may need a cardiology opinion, or for that ma.
| Author | : David J. Christini |
| Publisher | : |
| Total Pages | : 0 |
| Release | : 2020 |
| Genre | : Electrocardiography |
| ISBN | : 9780750320641 |
This book provides a thorough introduction to the topic of mathematical modeling of electrical activity in the heart, from molecular details of ionic channel dynamics to clinically derived patient-specific models. It discusses how cellular ionic models are formulated, introduces commonly used models and explains why there are so many different models available. The chapters cover modeling of the intracellular calcium handling that underlies cellular contraction as well as modeling molecular-level details of cardiac ion channels, and also focus on specialized topics such as cardiomyocyte energetics and signalling pathways. It is an excellent resource for experienced and specialised researchers in the field, but also biological scientists with a limited background in mathematical modelling and computational methods. Part of Biophysical Society-IOP series.
| Author | : H. Böhles |
| Publisher | : CRC Press |
| Total Pages | : 188 |
| Release | : 2004 |
| Genre | : Medical |
| ISBN | : 9783887631048 |
During the last years the understanding for the aetiology of cardiomyopathies could be greatly improved. A great deal of information has accumulated in the field of inherited metabolic diseases, which provides a new basis for our understanding of many heart muscle problems and their corresponding clinical disease entities. This book is meant to give the reader a comprehensive overview of the cardiological manifestations of inborn errors of metabolism. Latest information, such as cardiomyopathy in Fabry disease or in patients with CDG-syndrome is included. It should be helpful, not only to cardiologists, paediatricians, internists and general practicioners, but also to all those interested in a better understanding of the metabolic basis of clinical disease entities.
