Intake of caffeine and other methylxanthines during pregnancy and risk for adverse effects in pregnant women and their foetuses

Intake of caffeine and other methylxanthines during pregnancy and risk for adverse effects in pregnant women and their foetuses
Author: H. C. Andersson
Publisher: Nordic Council of Ministers
Total Pages: 390
Release: 2004
Genre: Medical
ISBN: 9289310987

The first part of the report deals with occurrence of methylxanthines in foods, beverages, and medicines, and estimates of caffeine intake. In addition, a short review of the pharmacological and toxicological actions of caffeine is given. The second and main part of the report reviews available information from epidemiological studies on the potential health hazards to the human foetus associated with parental intake during pregnancy of caffeine and related methylxanthines in foods, beverages and medicines. The studied adverse effects are influence on fertility, spontaneous abortion, congenital malformation, pre-term delivery, foetal growth retardation, foetal behaviour and effects on neonates, infants and young children. The conclusion of the report demonstrates the need for limiting caffeine exposure during pregnancy. The Nordic Working Group on Food Toxicology and Risk Evaluation (NNT) recognizes that the human exposure to caffeine and related compounds causes a spectrum of pharmacological effects, for instance cardiovascular, renal, neurological and behavioural effects. The increasing use of caffeine and related methylxanthines in various foods and beverages consumed by children and adolescents cause concern. NNT recommends that a full hazard characterization of caffeine and related methylxanthines should be performed with the aim to reach a conclusion about the upper safe level of intake of these compounds.

Proceedings from a Nordic Seminar

Proceedings from a Nordic Seminar
Author: Anja Hallikainen
Publisher: Nordic Council of Ministers
Total Pages: 158
Release: 2003
Genre: Potato industry
ISBN: 9789289308762

Yhteenveto. - Resumé. - Samantekt.

Biodiversity

Biodiversity
Author: Ewan J T Chrystal
Publisher: Royal Society of Chemistry
Total Pages: 322
Release: 2007-10-31
Genre: Science
ISBN: 1847550231

The continuing quest for new drugs and agrochemicals has seen researchers looking to the natural world for potential products. Plants and microorganisms have long been investigated as sources of new lead compounds, but the scope of this book has been widened to include substances derived from marine organisms. Advances in genetic engineering, high throughput screening and structure elucidation have also opened up further avenues for exploration. Competitive pressure from the field of combinatorial chemistry has expedited new approaches to natural product analysis and stimulated debate on the industrial utilization of natural products. Biodiversity: New Leads for the Pharmaceutical and Agrochemical Industries reviews and discusses aspects of modern natural products research. The central theme of many articles is the sustainable use of global biodiversity. Microbial, plant and marine products are presented as the sources of new drugs, including antifungal products, antibiotics, anticancer agents and animal health products. There is also coverage of the biosynthesis of polyketides and the chemical synthesis of natural products and their derivatives. A unique blend of industrial and academic perspectives on the importance of biodiversity and natural products, this book will prove an important source of state-of-the-art information for researchers, teachers and graduates in the chemical and biological sciences.

Alkaloids in edible lupin seeds

Alkaloids in edible lupin seeds
Author: Kirsten Pilegaard
Publisher: Nordic Council of Ministers
Total Pages: 74
Release: 2008
Genre: Science
ISBN: 9289318023

The report reviews the toxicity data on inherent natural toxicants in lupin seeds, especially quinolizidin alkaloids. Lupin seeds are increasingly used in the Nordic countries, partially substituting wheat flour in certain foods. An estimation of the risk by consuming foods containing lupin seeds in the Nordic countries and recommendations to better ensure the safe use of these seeds in foods are given.

Tropane Alkaloids

Tropane Alkaloids
Author: Vikas Srivastava
Publisher: Springer Nature
Total Pages: 179
Release: 2021-01-27
Genre: Medical
ISBN: 9813345357

This book covers the current research on the plant-based tropane alkaloids (TA) and TA-bearing plants. The first part includes an overview of “tropane alkaloids in context to diversity, biosynthesis and significance. The second part covers aspects of in-vitro and allied interventions in these alkaloids. TAs belong to one of the world’s oldest phytomedicines with their valuable ethno-pharmacological applications. The book compiles scientific ideas, perspectives and challenges in this area. Further, the book attempts to investigate the loopholes in existing methodologies, challenges and possible solutions through well thought-out scientific discussions from various eminent research groups. This book is of high interest to students and researchers in biotechnology, plant biology and pharmacology. As the TAs are of high commercial medicinal value, this book is also a relevant collection of articles for industry experts.

Toxic Plants and Other Natural Toxicants

Toxic Plants and Other Natural Toxicants
Author: Tam Garland
Publisher: CABI
Total Pages: 601
Release: 1998-01-01
Genre: Science
ISBN: 0851992633

Toxic plants and other natural toxicants have a variety of roles in the fields of human health, medical research and the production of safe food and also represent an economic problem in terms of animal health and crop production. Estimates of economic impact on livestock have ranged in the millions of dollars in countries such as Australia and the United States. This book brings together applied and fundamental research from botanists, chemists, biochemists, agricultural scientists, veterinarians and physicians and advice from regulatory bodies. It consists of more than 100 edited papers from the Fifth International Symposium on Poisonous Plants, held in Texas in May 1997. All aspects of poisonous plants, mycotoxicoses and herbal intoxications are covered. Their adverse effects are described, such as fatalities, reduced or failed reproduction, fetotoxicity, spontaneous abortions, deformities, reduced productivity and organ-specific toxicity. Methods of detection, isolation and identification of the chemical compounds responsible are included. The biochemistry of the plant-associated toxins and elucidation of their mechanism of action is investigated, including the protocols for management or eradication, immunization programs, behaviour modification, withholding periods for metabolic detoxification, regulatory advice concerning human usage of natural products and advice concerning toxin-residue in agricultural produce. The development of non-toxic strains of plants for use as fodder is also discussed. This book is essential reading for toxicologists concerned with animal and human health, food industry regulators and plant scientists.