This guide provides guidance to calibrate the Mechanistic-Empirical Pavement Design Guide (MEPDG) software to local conditions, policies, and materials. It provides the highway community with a state-of-the-practice tool for the design of new and rehabilitated pavement structures, based on mechanistic-empirical (M-E) principles. The design procedure calculates pavement responses (stresses, strains, and deflections) and uses those responses to compute incremental damage over time. The procedure empirically relates the cumulative damage to observed pavement distresses.