Calcium And Cell Physiology
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| Author | : D. Marme |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 398 |
| Release | : 2012-12-06 |
| Genre | : Science |
| ISBN | : 3642700705 |
The purpose of the present volume is to give a comprehensive and up-to-date 2 survey of the nature and role of calcium ions (Ca +) in the regulation of cel 2 lular function. Since Ca + has gained in interest over the past years as a cel lular messenger in signal transduction, and since the discovery of its cellular receptor protein, calmodulin, has helped in understanding its mode of action in molecular terms, we felt that an interdisciplinary selection of topics from the calcium field could provide a good source of information for all those in terested in calcium-mediated physiology. The volume begins with an overview on the synarchic nature of the two 2 cellular messengers, cyclic AMP and Ca +. The next three chapters deal with 2 the various transport mechanisms for Ca +. The biochemistry and molecular biology of calmodulin, as well as the cellular localization of calmodulin and calmodulin-binding proteins, are reviewed. Calcium regulation of smooth muscle contraction introduces the pharmacology of calcium antagonists.
| Author | : Wai Yiu Cheung |
| Publisher | : |
| Total Pages | : 536 |
| Release | : 1980 |
| Genre | : Medical |
| ISBN | : |
| Author | : Gary Fiskum |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 613 |
| Release | : 2013-04-17 |
| Genre | : Medical |
| ISBN | : 1468455982 |
A widespread appreciation for the role that calcium plays in cell physiology and patho physiology has now been achieved due to the pioneering studies of many of the scientists who attended the VIIth International Spring Symposium on Health Sciences at George Washington University in Washington, D. C. The participants in this unique meeting rep resented diverse fields of basic and clinical research, such as molecular physiology, oncology, molecular genetics, cardiology, bioenergetics, pathology, and endocrinology. The content of the proceedings of the symposium represents work in these and other areas of biomedical research. Organization of the book is aimed at striking a balance between the biochemistry 2 and physiology of normal cell Ca + metabolism and the pathological consequences of al 2 terations in cell Ca + homeostasis. The first section of the book is devoted to the transport mechanisms responsible for 2 2 regulating intracellular Ca + and the pharmacological modalities for controlling cell Ca + . Particular attention is given to the molecular basis for plasma membrane transport activities, 2 2 including the ATP-driven Ca + pump, the Na + -Ca + exchange system, and voltage sensitive 2 Ca + channels. The second section covers the exciting relationships between phosphoinositide metab 2 olism, signal transduction, and cell Ca + metabolism. This section begins with an eloquent overview by Professor Michael Berridge, who was the keynote speaker at the symposium and the recipient of the scientific merit award.
| Author | : Michel Félétou |
| Publisher | : Morgan & Claypool Publishers |
| Total Pages | : 309 |
| Release | : 2011 |
| Genre | : Science |
| ISBN | : 1615041230 |
The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in direct contact with the blood/lymph and the circulating cells. The endothelium is a major player in the control of blood fluidity, platelet aggregation and vascular tone, a major actor in the regulation of immunology, inflammation and angiogenesis, and an important metabolizing and an endocrine organ. Endothelial cells controls vascular tone, and thereby blood flow, by synthesizing and releasing relaxing and contracting factors such as nitric oxide, metabolites of arachidonic acid via the cyclooxygenases, lipoxygenases and cytochrome P450 pathways, various peptides (endothelin, urotensin, CNP, adrenomedullin, etc.), adenosine, purines, reactive oxygen species and so on. Additionally, endothelial ectoenzymes are required steps in the generation of vasoactive hormones such as angiotensin II. An endothelial dysfunction linked to an imbalance in the synthesis and/or the release of these various endothelial factors may explain the initiation of cardiovascular pathologies (from hypertension to atherosclerosis) or their development and perpetuation. Table of Contents: Introduction / Multiple Functions of the Endothelial Cells / Calcium Signaling in Vascular Cells and Cell-to-Cell Communications / Endothelium-Dependent Regulation of Vascular Tone / Conclusion / References
| Author | : Juliusz Ashot Kozak |
| Publisher | : CRC Press |
| Total Pages | : 343 |
| Release | : 2017-07-14 |
| Genre | : Science |
| ISBN | : 149875273X |
Calcium Entry Channels in Non-Excitable Cells focuses on methods of investigating the structure and function of non-voltage gated calcium channels. Each chapter presents important discoveries in calcium entry pathways, specifically dealing with the molecular identification of store-operated calcium channels which were reviewed by earlier volumes in the Methods in Signal Transduction series. Crystallographic and pharmacological approaches to the study of calcium channels of epithelial cells are also discussed. Calcium ion is a messenger in most cell types. Whereas voltage gated calcium channels have been studied extensively, the non-voltage gated calcium entry channel genes have only been identified relatively recently. The book will fill this important niche.
| Author | : |
| Publisher | : Academic Press |
| Total Pages | : 307 |
| Release | : 2013-07-24 |
| Genre | : Science |
| ISBN | : 0124079385 |
Store-operated calcium channels are found in most animal cells and regulate many cellular functions including cell division, growth, differentiation, and cell death. This volume provides a concise and informative overview of the principles of store-operated calcium entry and the key developments in the field from researchers who have led these advances. The overall goal of the volume is to provide interested students and investigators with sufficient information to enable a broad understanding of the progress and current excitement in the field. The volume contains a wealth of information that even experienced investigators in the field will find useful. - The volume provides a comprehensive overview of the mechanisms and functions of store-operated calcium channels - Contributors are authoritative researchers who have produced important advances in the field - The volume is well-illustrated with cartoons and data to facilitate easy comprehension of the subject
| Author | : James Sneyd |
| Publisher | : Springer |
| Total Pages | : 214 |
| Release | : 2005-06-13 |
| Genre | : Mathematics |
| ISBN | : 3540314385 |
This book presents a series of models in the general area of cell physiology and signal transduction, with particular attention being paid to intracellular calcium dynamics, and the role played by calcium in a variety of cell types. Calcium plays a crucial role in cell physiology, and the study of its dynamics lends insight into many different cellular processes. In particular, calcium plays a central role in muscular contraction, olfactory transduction and synaptic communication, three of the topics to be addressed in detail in this book. In addition to the models, much of the underlying physiology is presented, so that readers may learn both the mathematics and the physiology, and see how the models are applied to specific biological questions. It is intended primarily as a graduate text or a research reference. It will serve as a concise and up-to-date introduction to all those who wish to learn about the state of calcium dynamics modeling, and how such models are applied to physiological questions.
| Author | : Md. Shahidul Islam |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 1254 |
| Release | : 2012-04-19 |
| Genre | : Medical |
| ISBN | : 9400728875 |
Calcium signaling contains a unique selection of chapters that cover a wide range of contemporary topics in this ubiquitous and diverse system of cell signaling. This book has the flavor of a primary text book, but it is much more than that. It covers topics ranging from the fundamental aspects of calcium signaling to its clinical implications, in a thoughtful and comprehensive way. It discusses cutting edge researches, and critical issues at depth, and it presents many testable hypotheses for future research. It includes the theoretical and the methodological topics as well as topics related to mathematical modeling, and simulations. If you want to read about calcium signaling in different mammalian cells, oocytes, Zebrafishes, and even in plants, in one and the same book, then this book will not disappoint you. From the beginners to the experts in the field of calcium signaling, everybody will find something useful in this very timely book.
| Author | : James Sneyd |
| Publisher | : Springer |
| Total Pages | : 202 |
| Release | : 2009-09-02 |
| Genre | : Mathematics |
| ISBN | : 9783540809579 |
This book presents a series of models in the general area of cell physiology and signal transduction, with particular attention being paid to intracellular calcium dynamics, and the role played by calcium in a variety of cell types. Calcium plays a crucial role in cell physiology, and the study of its dynamics lends insight into many different cellular processes. In particular, calcium plays a central role in muscular contraction, olfactory transduction and synaptic communication, three of the topics to be addressed in detail in this book. In addition to the models, much of the underlying physiology is presented, so that readers may learn both the mathematics and the physiology, and see how the models are applied to specific biological questions. It is intended primarily as a graduate text or a research reference. It will serve as a concise and up-to-date introduction to all those who wish to learn about the state of calcium dynamics modeling, and how such models are applied to physiological questions.
| Author | : Nicholas Sperelakis |
| Publisher | : Elsevier |
| Total Pages | : 1262 |
| Release | : 2012-12-02 |
| Genre | : Science |
| ISBN | : 0080574556 |
This authoritative book gathers together a broad range of ideas and topics that define the field. It provides clear, concise, and comprehensive coverage of all aspects of cellular physiology from fundamental concepts to more advanced topics. The Third Edition contains substantial new material. Most chapters have been thoroughly reworked. The book includes chapters on important topics such as sensory transduction, the physiology of protozoa and bacteria, the regulation of cell division, and programmed cell death. - Completely revised and updated - includes 8 new chapters on such topics as membrane structure, intracellular chloride regulation, transport, sensory receptors, pressure, and olfactory/taste receptors - Includes broad coverage of both animal and plant cells - Appendixes review basics of the propagation of action potentials, electricity, and cable properties - Authored by leading experts in the field - Clear, concise, comprehensive coverage of all aspects of cellular physiology from fundamental concepts to more advanced topics
