Caged Compounds
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| Author | : Gerard Marriott |
| Publisher | : Academic Press |
| Total Pages | : 584 |
| Release | : 1998-06-22 |
| Genre | : Medical |
| ISBN | : |
The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. More than 285 volumes have been published (all of them still in print) and much of the material is relevant even today--truly an essential publication for researchers in all fields of life sciences.
| Author | : Robert A. Scott |
| Publisher | : John Wiley & Sons |
| Total Pages | : 597 |
| Release | : 2007-12-10 |
| Genre | : Science |
| ISBN | : 0470032170 |
Modern spectroscopic and instrumental techniques are essential to the practice of inorganic and bioinorganic chemistry. This first volume in the new Wiley Encyclopedia of Inorganic Chemistry Methods and Applications Series provides a consistent and comprehensive description of the practical applicability of a large number of techniques to modern problems in inorganic and bioinorganic chemistry. The outcome is a text that provides invaluable guidance and advice for inorganic and bioinorganic chemists to select appropriate techniques, whilst acting as a source to the understanding of these methods. This volume is also available as part of Encyclopedia of Inorganic Chemistry, 5 Volume Set. This set combines all volumes published as EIC Books from 2007 to 2010, representing areas of key developments in the field of inorganic chemistry published in the Encyclopedia of Inorganic Chemistry. Find out more.
| Author | : D. Lansing Taylor |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 437 |
| Release | : 2008-02-04 |
| Genre | : Science |
| ISBN | : 1597452173 |
There has always been some tension between proponents of hypothesis-driven and discovery-driven research in the broad field of life sciences. Academic research has been primarily focused on hypothesis-driven research. However, the success of the human genome project, a discovery-driven research approach, has opened the door to adding other types of discovery-driven research to a continuum of research approaches. In contrast, drug discovery research in the pharmaceutical industry has embraced discovery-driven research for many years. A good example has been the discovery of active compounds from large chemical libraries, through screening campaigns. The success of the human genome project has also demonstrated the need for both academic researchers and industrial researchers to now understand the functions of genes and gene products. The cell is the basic unit of life and it has been at the cellular level where function can be demonstrated most cost-effectively and rapidly. High content screening (HCS) was developed by Cellomics Inc. in the mid-1990s to address the need for a platform that could be used in the discovery-driven research and development required to understand the functions of genes and gene products at the level of the cell.
| Author | : |
| Publisher | : Academic Press |
| Total Pages | : 417 |
| Release | : 1995-10-10 |
| Genre | : Science |
| ISBN | : 0080536468 |
This practical book provides the detailed methodology and expert guidance required for measuring and manipulating cytosolic ion concentrations. In addition, the strengths, weaknesses, and pitfalls of various techniques are presented. It is an invaluable source for those needing an objective evaluation of current methodologies and for those contemplating setting up such procedures. - A one-source reference for measuring and manipulating intracellular ions and for comparing and evaluating current methodologies - Includes overviews of Optical probes and reagents - Fabrication and use of ion-selective microelectrodes - Use of NMR spectroscopy - Ionophores
| Author | : |
| Publisher | : Academic Press |
| Total Pages | : 330 |
| Release | : 2020-05-13 |
| Genre | : Medical |
| ISBN | : 0128201886 |
From Structure to Clinical Development: Allosteric Modulation of G Protein-Coupled Receptors, Volume 88, the latest release in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this updated edition include Targeting muscarinic M1 receptor in neurodegeneration, Photo-switchable allosteric ligands, Computational approaches for the design of mGlu receptor allosteric modulators, Allosteric modulation of GLP-1 receptor in metabolic disorders, Group II mGluR roles in the nervous system and their roles in addiction, RAMPs as allosteric modulators of Class B GPCRs, Structure-based discovery and development of mGlu5 NAMs, and much more. - Includes the authority and expertise of leading contributors in pharmacology - Presents the latest release in the Advances in Pharmacology series
| Author | : Ravi Iyengar |
| Publisher | : Elsevier |
| Total Pages | : 492 |
| Release | : 1994-09-08 |
| Genre | : Medical |
| ISBN | : 9780121821395 |
This volume of Methods in Enzymology and its companion Volume 237 include molecular, biological, and biochemical methods for the study of cell surface heterotrimeric G proteins and their effectors. Methods unique to signal transducing G proteins and general techniques that have been applied to the study of G protein systems are covered.
| Author | : Michael Barany |
| Publisher | : Elsevier |
| Total Pages | : 455 |
| Release | : 1996-01-04 |
| Genre | : Science |
| ISBN | : 0080527892 |
This valuable resource provides a systematic account of the biochemistry of smooth muscle contraction. As a comprehensive guide to this rapidly growing area of research, it covers the structure and characteristic properties of contractile and regulatory proteins, with special emphasis on their predicted function in the live muscle. Also included in this book are intermediate filament proteins, and desmin and vimentin, whose function in smooth muscle is unknown; and several enzymes involved in the phosphorylation-dephosphorylation of contractile and other proteins.
| Author | : |
| Publisher | : Academic Press |
| Total Pages | : 300 |
| Release | : 2019-07-30 |
| Genre | : Science |
| ISBN | : 0128170298 |
Optochemical Biology, Volume 624, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters on a variety of topics, including Cell Lineage Tracing in Zebrafish Embryos with an Expanded Genetic Code, Optical Control of Tumor Induction in the Zebrafish, Optogenetic Control by Pulsed Illumination, Optimizing the Photocontrol of bZIP Coiled Coils with Azobenzene Crosslinkers: Role of the Crosslinking Site, Site-Directed RNA Editing in Vivo Can Be Triggered by the Light-Driven Assembly of an Artificial Riboprotein, In Situ Formation of an Azo Bridge on Proteins Controllable by Visible Light, and much more. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in the Methods in Enzymology series - Includes the latest information on optochemical biology
| Author | : Royal Society (Great Britain) |
| Publisher | : Oxford [England] ; New York : Oxford University Press |
| Total Pages | : 194 |
| Release | : 1992 |
| Genre | : Language Arts & Disciplines |
| ISBN | : 9780198557814 |
The papers presented in this volume report the striking progress X-ray diffraction has facilitated in the study of structural molecular biology. Coupled with the revival of the Laue method, the advent of high-intensity synchrotron radiation sources has made possible the rapid collection of X-ray crystallography data, thereby allowing protein and virus crystallography to progress from studies of equilibrium structures to time-resolved studies of structures at reaction stages. The book also details the many recent technological developments in physics, chemistry and biochemistry that have been critical for the full exploitation of the synchrotron Laue method in the study of dynamic events in crystals. Necessary future developments are discussed.
| Author | : Zbigniew L. Pianowski |
| Publisher | : John Wiley & Sons |
| Total Pages | : 1577 |
| Release | : 2022-06-01 |
| Genre | : Science |
| ISBN | : 3527827617 |
A comprehensive overview about the emerging field of photoswitches and their applications in materials science and biology Molecular Photoswitches guides the reader through the basic molecular structures of photochromic compounds and their applications in the area of photoresponsive materials as well as in the biological context. The initial chapters describe individual classes of molecular photoswitches, introducing their principles of photochromism, typical switching wavelengths, thermal stability of photoisomers and other key information, which is ordinarily spread in the literature. These classes comprise i.a. azobenzenes, diazocines, arylazoheterocycles, arylhydrazones, indigoids, photochromic imines, or acylhydrazones. The book also covers: Catalysis with molecular switches Applications in photochromic porous materials, liquid crystals, or nanoparticles Light-responsive molecular machines, logic devices, and molecular magnets Photomodulation of biological systems: photoswitchable biopolymers, lightmodulated antibiotics, cytotoxins, ion channel inhibitors, light-propelled artificial muscles, and computationally designed photochromic proteins This two-volume work is a valuable guide for researchers and non-experts working in the field of photochemistry, organic chemistry, catalysis, materials science, biology, and medicine.
