C Elegans
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| Author | : Donald L. Riddle |
| Publisher | : Firefly Books |
| Total Pages | : 1252 |
| Release | : 1997 |
| Genre | : Medical |
| ISBN | : 9780879695323 |
Defines the current status of research in the genetics, anatomy, and development of the nematode C. elegans, providing a detailed molecular explanation of how development is regulated and how the nervous system specifies varied aspects of behavior. Contains sections on the genome, development, neural networks and behavior, and life history and evolution. Appendices offer genetic nomenclature, a list of laboratory strain and allele designations, skeleton genetic maps, a list of characterized genes, a table of neurotransmitter assignments for specific neurons, and information on codon usage. Includes bandw photos. For researchers in worm studies, as well as the wider community of researchers in cell and molecular biology. Annotation copyrighted by Book News, Inc., Portland, OR
| Author | : |
| Publisher | : |
| Total Pages | : 1222 |
| Release | : 1997 |
| Genre | : Caenorhabditis elegans |
| ISBN | : 9780879694883 |
| Author | : Donald L. Riddle |
| Publisher | : |
| Total Pages | : 1222 |
| Release | : 1996-12-31 |
| Genre | : Science |
| ISBN | : 9780879694883 |
Studies of the cells and genes of the nematode C. elegans have become a cornerstone of current biology. This monograph defines the current status of the field, providing a molecular explanation of how development is regulated and the nervous system specifies various aspects of behaviour.
| Author | : Jerry J. Buccafusco |
| Publisher | : CRC Press |
| Total Pages | : 341 |
| Release | : 2000-08-29 |
| Genre | : Medical |
| ISBN | : 1420041819 |
Using the most well-studied behavioral analyses of animal subjects to promote a better understanding of the effects of disease and the effects of new therapeutic treatments on human cognition, Methods of Behavior Analysis in Neuroscience provides a reference manual for molecular and cellular research scientists in both academia and the pharmaceutic
| Author | : William Barry Wood |
| Publisher | : |
| Total Pages | : 694 |
| Release | : 1988 |
| Genre | : Science |
| ISBN | : |
| Author | : David H. Hall |
| Publisher | : CSHL Press |
| Total Pages | : 353 |
| Release | : 2008 |
| Genre | : Caenorhabditis elegans |
| ISBN | : 0879697156 |
Derived from the acclaimed online “WormAtlas,†C. elegansAtlas is a large-format, full-color atlas of the hermaphroditic form of the model organism C. elegans, known affectionately as “the worm†by workers in the field. Prepared by the editors of the WormAtlas Consortium, David H. Hall and Zeynep F. Altun, this book combines explanatory text with copious, labeled, color illustrations and electron micrographs of the major body systems of C. elegans. Also included are electron microscopy cross sections of the worm. This laboratory reference is essential for the working worm biologist, at the bench and at the microscope, and provides a superb companion to the C. elegansII monograph. It is also a valuable tool for investigators in the fields of developmental biology, neurobiology, reproductive biology, gene expression, and molecular biology.
| Author | : Dayong Wang |
| Publisher | : Springer |
| Total Pages | : 447 |
| Release | : 2019-01-24 |
| Genre | : Medical |
| ISBN | : 9811336334 |
This book will focus on the molecular basis of oxidative stress induced by toxicants or stresses and various molecular signalling pathways in regulating the toxicity of toxicants or stresses in Caenorhabditis elegans. It will also cover the discussion on the aspects of response signals, G-protein coupled receptors and ion channels, specific molecular signals, and epigenetic signals involved in the regulation of toxicity from toxicants or stresses. The molecular basis for adaptive response for transgenerational toxicity of environmental toxicants or stresses will be further discussed. Nematode Caenorhabditis elegans is a classic model animal with well-described genetic and developmental backgrounds based on the study of life science, and has been further successfully and widely used in both toxicity assessment and toxicological study of various environmental toxicants or stresses. Based on related available data, this book aims at providing a systematic understanding of the knowledge system of molecular toxicology in C. elegans.
| Author | : Ian A. Hope |
| Publisher | : OUP Oxford |
| Total Pages | : 306 |
| Release | : 1999-12-09 |
| Genre | : Science |
| ISBN | : 019159198X |
Caenorhabditis Elegans has been a popular model organism for biological research for over thirty years and has been used to investigate many aspects of animal development, for example apoptosis, the Hox genes, signal transduction pathways, and the development of the nervous system. It has recently taken on new importance with the publication of the entire genome sequence in 1998. The first chapter gives all the basic information on C. elegans required to use it: it's natural history, anatomy, life cycle, development, and evolution. Information on how to obtain, grow, and maintain C. elegans for use as a model system is given in Chapter 4. Chapters 2 and 3 describe the genome project and show how to use genome sequence information by searching the database for homologues using different search methods and then how to analyse the search data. The next chapter gives the essential practical details of transformation and common uses for the technique. Chapter 6 covers reverse genetics and describes strategies for gene inactivation that are known to work in C elegans: epigenetic inactivation and mutational germ line inactivation. Chapter 7 is designed to help the user analyse phenotype by microscopy and includes Normaski, fluorescence, 4-dimensional, and electron microscopy. Techniques for studying the neurobiology of C. elegans are given in chapter 8. Chapter 9 describes the three commonly used approaches for studying gene expression and Chapter 10 deals with the common methods of molecular biology essential for gene characterization. C. elegans is not the ideal organism for biochemical studies, but chapter 11 describes several procedures for producing biochemically useful quantities of pure tissues. The final chapter is about conventional genetics and details the standard procedures for selfing and crossing; mutagenesis and mutant screening; characterization of mutants; gene mapping; temperature-shift experiments and mosaic analysis. Caenorhabditis Elegans: A Practical Approach will therefore provide all the background information necessary for use of C. elegans as a model system.
| Author | : Henry F. Epstein |
| Publisher | : Academic Press |
| Total Pages | : 687 |
| Release | : 1995 |
| Genre | : Caenorhabditis elegans |
| ISBN | : 0125641494 |
The first of its kind, this laboratory handbook emphasizes diverse methods and technologies needed to investigate C. elegans, both as an integrated organism and as a model system for research inquiries in cell, developmental, and molecular biology, as well as in genetics and pharmacology. Four primary sections--Genetic and Culture Methods, Neurobiology, Cell and Molecular Biology, and Genomics and Informatics--reflect the cross-disciplinary nature of C. elegans research. Because C. elegans is a simple and malleable organism with a small genome and few cell types, it provides an elegant demonstr.
| Author | : Kevin Strange |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 292 |
| Release | : 2008-02-05 |
| Genre | : Medical |
| ISBN | : 1597451517 |
Molecular biology has driven a powerful reductionist, or “molecule-c- tric,” approach to biological research in the last half of the 20th century. Red- tionism is the attempt to explain complex phenomena by defining the functional properties of the individual components of the system. Bloom (1) has referred to the post-genome sequencing era as the end of “naïve reductionism. ” Red- tionist methods will continue to be an essential element of all biological research efforts, but “naïve reductionism,” the belief that reductionism alone can lead to a complete understanding of living organisms, is not tenable. Organisms are clearly much more than the sum of their parts, and the behavior of complex physiological processes cannot be understood simply by knowing how the parts work in isolation. Systems biology has emerged in the wake of genome sequencing as the s- cessor to reductionism (2–5). The “systems” of systems biology are defined over a wide span of complexity ranging from two macromolecules that interact to carry out a specific task to whole organisms. Systems biology is integrative and seeks to understand and predict the behavior or “emergent” properties of complex, multicomponent biological processes. A systems-level characteri- tion of a biological process addresses the following three main questions: (1) What are the parts of the system (i. e.
