Brain Tumor Pathology Current Diagnostic Hotspots And Pitfalls
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Author | : Davide Schiffer |
Publisher | : Springer Science & Business Media |
Total Pages | : 272 |
Release | : 2006-07-28 |
Genre | : Medical |
ISBN | : 1402039980 |
Since Bailey and Cushing (1926), all brain tumor classifications have been called histogenetic. The nosographic position that the tumor types progressively acquired in the classification systems derived from the resemblance of tumor cells to those of the cytogenesis, modified whenever new information became available from different biological research fields and especially from molecular genetics. Classically, on the basis of the rough correspondence between the mature/immature aspect of tumor cells and the benign/malignant biological behavior of the tumors, the histological labels contained a prognostic significance. The supposed origin of the tumors was thus a factor for prognosis. Later on, with the concept of anaplasia (Cox, 1933; Kernohan et al., 1949) new criteria were introduced for establishing the malignancy grades of tumors. Immunohistochemistry and later molecular genetics further refined the prognostic diagnoses, substantially increasing the opportunities to recognize the cell origin of tumors, beside revealing the pathogenetic mechanisms. Prognoses became more accurate, as required by the greater and more targeted possibilities of therapy.
Author | : Davide Schiffer |
Publisher | : Springer Science & Business Media |
Total Pages | : 288 |
Release | : 2006-03-09 |
Genre | : Medical |
ISBN | : 9781402039973 |
This book is not a treatise on brain tumor pathology and nosography. It has been conceived as a help to pathologists, neuropathologists and neuro-oncologists in confronting everyday problems arising in the diagnostics of brain tumors. Today, because of scientific advances in clinical diagnosis brain tumors are operated earlier, when they are still of reduced dimensions, and with new techniques and more frequently they undergo biopsy procedures. As a consequence, surgical samples for diagnosis are of a smaller size. On the other hand, the recourse to therapies ever more selective require more and more precise identification of tumor types and grades and quite often reliance must be placed on a limited number of cells, as tumor morphological patterns are no longer available. The ever greater precision leads to an increased risk of a flawed diagnosis. The book aims to illustrate the pitfalls most frequently encountered today in the practical activity of diagnosis and also of prognosis. The initial chapters cover the distinction between infiltrating tumors and normal nervous tissue, between diffuse astrocytoma and oligodendroglioma and the identification of the malignant variant of some tumor types. Moreover, in the pathology of brain tumors, some biological processes are active which show a development over the course of time, such that in surgical samples they cannot be recognized as a whole, but only from the occurrence of limited and partial aspects. Invasion modalities, angiogenesis and apoptosis fall in this category and are discussed not in an exhaustive manner, but as stages or phases of the processes identified in the tissue. The figures do not seek to illustrate the characteristic aspects of the tumors, but only the points under discussion.This book is the result of many years of personal experience in the diagnosis of brain tumors as well as of discussions with neurosurgeons and neuro-oncologists and it aspires to contribute to solving emerging everyday problems.
Author | : Andreana Rivera |
Publisher | : Lippincott Williams & Wilkins |
Total Pages | : 592 |
Release | : 2015-04-28 |
Genre | : Medical |
ISBN | : 149631879X |
Apply a state-of-the-art, integrated approach to brain cancer diagnosis and staging withAdvances in Surgical Pathology: Brain Cancer. Distinguished experts provide you with concise, current, and well-rounded guidance on all 130 brain tumor entities listed in the most recent WHO classification, with an emphasis on practical issues and new developments. This cutting-edge surgical pathology reference is an ideal tool to help you update your knowledge and skills and solve difficult diagnostic dilemmas, as well as a valuable resource for certification and recertification preparation.
Author | : Jan E. Leestma |
Publisher | : CRC Press |
Total Pages | : 766 |
Release | : 2008-10-14 |
Genre | : Law |
ISBN | : 1420008684 |
Over the past 30 years, as both forensic pathology and neuropathology have grown in sophistication, the two specialties have forged a heightened level of interaction. Reflecting the vast increase in knowledge and scientific progress in the past two decades, Forensic Neuropathology, Second Edition examines the new developments that have arisen since
Author | : Terry Lichtor |
Publisher | : BoD – Books on Demand |
Total Pages | : 652 |
Release | : 2013-02-27 |
Genre | : Medical |
ISBN | : 9535109898 |
A dramatic increase in knowledge regarding the molecular biology of brain tumors has been established over the past few years. In particular recent new avenues regarding the role of stem cells and microRNAs along with further understanding of the importance of angiogenesis, immunotherapy and explanations for the resistance of the tumors to chemotherapeutic agents and radiation therapy has been developed. It is hopeful that this new information will lead to efficacious treatment strategies for these tumors which remain a challenge. In this book a review of the latest information on these topics along with a variety of new therapeutic treatment strategies with an emphasis on molecular targeted therapies is provided.
Author | : Lee Roy Morgan |
Publisher | : BoD – Books on Demand |
Total Pages | : 274 |
Release | : 2014-06-11 |
Genre | : Medical |
ISBN | : 9535115766 |
A novel concept that is reviewed and discussed in several chapters in the book alludes to the transport of drugs bound to red blood cells into the highly vascular CNS tumors - both primary and metastatic. Such a transport mechanism is unique and of significant therapeutic potential. It is hopeful that the novel information presented in this book will result in new approaches to the treatment CNS tumors.
Author | : Peter B. Barker |
Publisher | : Cambridge University Press |
Total Pages | : 275 |
Release | : 2010 |
Genre | : Medical |
ISBN | : 052186898X |
Covers all MR spectroscopy techniques and their clinical applications in neurological disorders, malignancies and musculoskeletal diseases.
Author | : Miklos Garami |
Publisher | : BoD – Books on Demand |
Total Pages | : 477 |
Release | : 2011-09-22 |
Genre | : Medical |
ISBN | : 9533076461 |
Management of CNS Tumors is a selected review of Central Nervous System (CNS) tumors with particular emphasis on pathological classification and complex treatment algorithms for each common tumor type. Additional detailed information is provided on selected CNS tumor associated disorders.
Author | : Mike R. Schoenberg |
Publisher | : Springer Science & Business Media |
Total Pages | : 974 |
Release | : 2011-01-11 |
Genre | : Psychology |
ISBN | : 0387769781 |
From translating the patient’s medical records and test results to providing recommendations, the neuropsychological evaluation incorporates the science and practice of neuropsychology, neurology, and psychological sciences. The Little Black Book of Neuropsychology brings the practice and study of neuropsychology into concise step-by-step focus—without skimping on scientific quality. This one-of-a-kind assessment reference complements standard textbooks by outlining signs, symptoms, and complaints according to neuropsychological domain (such as memory, language, or executive function), with descriptions of possible deficits involved, inpatient and outpatient assessment methods, and possible etiologies. Additional chapters offer a more traditional approach to evaluation, discussing specific neurological disorders and diseases in terms of their clinical features, neuroanatomical correlates, and assessment and treatment considerations. Chapters in psychometrics provide for initial understanding of brain-behavior interpretation as well as more advanced principals for neuropsychology practice including new diagnostic concepts and analysis of change in performance over time. For the trainee, beginning clinician or seasoned expert, this user-friendly presentation incorporating ‘quick reference guides’ throughout which will add to the practice armentarium of beginning and seasoned clinicians alike. Key features of The Black Book of Neuropsychology: Concise framework for understanding the neuropsychological referral. Symptoms/syndromes presented in a handy outline format, with dozens of charts and tables. Review of basic neurobehavioral examination procedure. Attention to professional issues, including advances in psychometrics and diagnoses, including tables for reliable change for many commonly used tests. Special “Writing Reports like You Mean It” section and guidelines for answering referral questions. Includes appendices of practical information, including neuropsychological formulary. The Little Black Book of Neuropsychology is an indispensable resource for the range of practitioners and scientists interested in brain-behavior relationships. Particular emphasis is provided for trainees in neuropsychology and neuropsychologists. However, the easy to use format and concise presentation is likely to be of particular value to interns, residents, and fellows studying neurology, neurological surgery, psychiatry, and nurses. Finally, teachers of neuropsychological and neurological assessment may also find this book useful as a classroom text. "There is no other book in the field that covers the scope of material that is inside this comprehensive text. The work might be best summed up as being a clinical neuropsychology postdoctoral residency in a book, with the most up to date information available, so that it is also an indispensible book for practicing neuropsychologists in addition to students and residents...There is really no book like this available today. It skillfully brings together the most important foundationsof clinical neuropsychology with the 'nuts and bolts' of every facet of assessment. It also reminds the more weathered neuropsychologists among us of the essential value of neuropsychological assessment...the impact of the disease on the patient’s cognitive functioning and behavior may only be objectively quantified through a neuropsychological assessment." Arch Clin Neuropsychol (2011) first published online June 13, 2011 Read the full review acn.oxfordjournals.org
Author | : Amit Agrawal |
Publisher | : BoD – Books on Demand |
Total Pages | : 490 |
Release | : 2016-07-13 |
Genre | : Medical |
ISBN | : 9535124250 |
The book contains the information of various aspects of newer developments and recent advances in the field of central nervous system (CNS) tumor molecular biology, tumor progression, clinical presentation, imaging and management. The authors from different reputed institutions shared their knowledge on this open access platform to disseminate their knowledge at global level. As it is obvious in the current text, the field of neurooncology is heterogeneous and under continuous development with addition of new knowledge and information on regular basis. The collective contributions from experts attempt to provide updates regarding ongoing research and developments pertaining to CNS tumor genetics and molecular aspects and their applied aspect in reference to patient management.