This economic literature research emerged as evidence on the impact of Brain Drain (Skilled Workers) as a critical role in developing countries. In this paper, we tested emigration panel data estimations for a sample of all Sub-Saharan African countries. Our empirical strategy plan employs the Fixed Effect and Random Effect regression analysis techniques on a unique model. We utilized a dataset of 43 Sub-Saharan African countries between 2004-2015. We show that economic down in most African countries is likely to cause increases in Brain Drain turnover in the region. Additionally, our panel data tested the wide range of diminishing returns and the prediction model of emigration rates in this region. The estimated cross-region findings in this region of the combined effects increase on Brain Drain have caused a frequency of prone economies. However, the main cause for the present poverty in the region is due to poor African political specifications.