The 48-year U.S. embargo on Cuba aims to deny resources to the Castro regime by prohibiting most trade, travel, and financial transactions with Cuba. The Depts. of Commerce, Homeland Security, Justice, and the Treasury are responsible for enforcing the embargo as well as protecting homeland and national security. Since 2001, U.S. agencies have changed the embargo¿s rules in response to new laws and policies. This report examines: (1) the rule changes in 2001-2005 and their impact on U.S. exports, travel, cash transfers, and gifts to Cuba; (2) U.S. agencies¿ embargo-related activities and workloads; and (3) factors affecting the embargo¿s enforcement. Includes recommendations. Charts and tables.