Biosynthesis Of Elastin
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Author | : Ladislas Robert |
Publisher | : CRC Press |
Total Pages | : 325 |
Release | : 2021-05-30 |
Genre | : Science |
ISBN | : 1000443426 |
Written by internationally known European and American scientists, these volumes systematically present many topics in the elastin and elastases fields. Volume I explains elastin, its biosynthesis, physicochemical properties, and alteration in a variety of pathologies and with aging. Volume II describes elastases, their physiological and pathological roles and their control by natural and synthetic inhibitors. Filled with illustrations and figures, these volumes will benefit researchers, physicians, and industrial scientists.
Author | : Ladislas Robert |
Publisher | : CRC Press |
Total Pages | : 336 |
Release | : 1989-04-30 |
Genre | : Medical |
ISBN | : 9780849364280 |
Written by internationally known European and American scientists, these volumes systematically present many topics in the elastin and elastases fields. Volume I explains elastin, its biosynthesis, physicochemical properties, and alteration in a variety of pathologies and with aging. Volume II describes elastases, their physiological and pathological roles and their control by natural and synthetic inhibitors. Filled with illustrations and figures, these volumes will benefit researchers, physicians, and industrial scientists.
Author | : E.D. Hay |
Publisher | : Springer Science & Business Media |
Total Pages | : 478 |
Release | : 2013-11-11 |
Genre | : Science |
ISBN | : 1461537703 |
In the ten-year interval since the first edition of this volume went to press, our knowledge of extracellular matrix (ECM) function and structure has enor mously increased. Extracellular matrix and cell-matrix interaction are now routine topics in the meetings and annual reviews sponsored by cell biology societies. Research in molecular biology has so advanced the number of known matrix molecules and the topic of gene structure and regulation that we won dered how best to incorporate the new material. For example, we deliberated over the inclusion of chapters on molecular genetics. We decided that with judicious editing we could present the recent findings in molecular biology within the same cell biology framework that was used for the first edition, using three broad headings: what is extracellular matrix, how is it made, and what does it do for cells? Maintaining control over the review of literature on the subject of ECM was not always an easy task, but we felt it was essential to production of a highly readable volume, one compact enough to serve the the student as an introduction and the investigator as a quick update on graduate the important recent discoveries. The first edition of this volume enjoyed con hope the reader finds this edition equally useful. siderable success; we D. Hay Elizabeth vii Contents Introductory Remarks 1 Elizabeth D. Hay PART I. WHAT IS EXTRACELLULAR MATRIX? Chapter 1 Collagen T. F. Linsenmayer 1. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 2. The Collagen Molecule . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 2. 1. Triple-Helical Domain(s) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Author | : Lily Lee Salcedo |
Publisher | : |
Total Pages | : 126 |
Release | : 1970 |
Genre | : Elastic tissue |
ISBN | : |
Author | : Eric A. Jaffe |
Publisher | : Springer Science & Business Media |
Total Pages | : 471 |
Release | : 2012-12-06 |
Genre | : Medical |
ISBN | : 146132825X |
The participation of endothelial cells in various physiologic and pathologic processes has been hypothesized since before the turn of the century. However, until recently, direct evidence for endothelial involvement in these processes has been extremely difficult to obtain due to the inability to study endothelial cell function in vitro. Though the possibility of using cultured endothelial cells to study endothelial cell function in vitro was recognized many years ago, the inability to culture unambiguously identifiable endothelial cells limited investigators in their studies of endothelial function. As a result, the field of endothelial cell biology lay relatively fallow for many years. The development in the early 1970's of routine and easily implemented methods for culturing human endothelial cells and the demonstration that cultured endothelial cells synthesized a physiologically relevant protein, Factor VIII/von Willebrand Factor, quickly changed this state of affairs. Over the following decade the scope of endothelial cell research rapidly widened, spreading in a number of directions. First, methods were developed to culture endothelial cells from a variety of species. Second, methods were developed to culture endothelial cells from different organs and types of blood vessels (arteries, veins, and capillaries) within a single species. Third, and most important, investigators began using cultured endothelial cells as tools to study the potential involvement of endothelial cells in a wide assortment of biologically interesting processes. The net result has been a tremendous increase in our understanding of endothelial cell function.
Author | : Lindsey Louise Barrineau |
Publisher | : |
Total Pages | : 130 |
Release | : 1980 |
Genre | : |
ISBN | : |
Author | : Robert Paul Mecham |
Publisher | : |
Total Pages | : 496 |
Release | : 1977 |
Genre | : Elastomers |
ISBN | : |
Author | : Beat H. Walpoth |
Publisher | : Springer |
Total Pages | : 0 |
Release | : 2020-08-21 |
Genre | : Science |
ISBN | : 9783030053352 |
Cardiovascular diseases are still the leading cause of death in developed countries. Revascularization procedures such as coronary artery and peripheral bypass grafts, as well as access surgery represent a 2$ billion market yearly for the US alone. Despite intense research over many decades, no clinically suitable, shelf-ready, synthetic, vascular, small-caliber graft exists. There is therefore still a quest for such a clinical vascular prosthesis for surgical revascularization procedures and access surgery. Many approaches have been tried and are currently under investigation with promising results. These range from acellular and cell-based, stable or bio-degradable, synthetic scaffolds to biological or decellularized grafts, not forgetting self-assembly technologies for in vitro or in vivo VTE. All these approaches can be further enhanced by functionalization, e.g. with growth factors and drug elution. This updatable book aims to cover all the relevant aspects of Vascular Tissue Engineering (VTE) and novel alternatives to develop vascular grafts for clinical applications. The chapters in this book cover different aspects of manufacturing scaffolds with various polymers, mechanical characteristics, degradation rates, decellularization techniques, cell sheet assembly, 3-D printing and autologous mandril-based VTE. All the necessary in vitro tests such as biocompatibility and thrombogenicity are reviewed. Pre-clinical assessment of in vivo experimental models include patency, compliance, intimal hyperplasia, inflammatory reaction, cellular ingrowth and remodeling. Finally, early clinical trials will be periodically updated regarding results, regulatory aspects and post-marketing quality assessment. Furthermore, the reader should get an insight into various approaches, technologies and methods to better understand the complexity of blood surface and cell interactions in VTE. Translational research has yielded early human applications clearly showing the enormous need of research in the field to provide better solutions for our patients and this continuously updated book will hopefully become a reference in the field for life sciences.
Author | : |
Publisher | : |
Total Pages | : |
Release | : |
Genre | : |
ISBN | : |
Author | : Derek J. Chadwick |
Publisher | : John Wiley & Sons |
Total Pages | : 374 |
Release | : 2008-04-30 |
Genre | : Science |
ISBN | : 0470514787 |
Drawing together contributions from a diverse group of international experts in the field, this collection of papers examines the biology and pathology of elastin at the molecular level. Topics include the structure, ultrastructure and function of elastin; elastin regulation; elastin's role in aging, lung development and disease and atherosclerosis; as well as related aspects of pharmacology and nutrition.