Biosynthesis And Molecular Genetics Of Fungal Secondary Metabolites
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| Author | : Nancy P. Keller |
| Publisher | : Humana Press |
| Total Pages | : 288 |
| Release | : 2012-10-14 |
| Genre | : Science |
| ISBN | : 9781627031219 |
Filamentous fungi have long been known for their ability to produce an enormous range of unusual chemical compounds known as secondary metabolites, many of which have potentially useful antibiotic or pharmacological properties. Recent focus on fungal genomics coupled with advances in detection and molecular manipulation techniques has galvanized a revitalization of this field. Fungal Secondary Metabolism: Methods and Protocols is aimed at providing the key methodologies currently in use and necessary for accessing and exploiting the natural product information provided by the genomes of this large and varied kingdom. Written by active researchers in the field, the chapters deal with all the steps necessary, from optimization of fungal culture conditions for metabolite production, through rapid genome sequencing and bioinformatics, and genetic manipulations for functional analysis, to detection and testing of metabolites. In addition, chapters on basic science address approaches to the genetic regulation, protein biochemistry, and cellular localization of the biosynthetic pathways. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and hands-on, Fungal Secondary Metabolism: Methods and Protocols encourages new investigators to enter the field and expands upon the expertise and range of skills of those already researching fungal natural products.
| Author | : Juan-Francisco Martín |
| Publisher | : Springer |
| Total Pages | : 357 |
| Release | : 2014-09-09 |
| Genre | : Science |
| ISBN | : 1493911910 |
This volume describes the more relevant secondary metabolites of different fungi with current information on their biosynthesis and molecular genetics. Bolstered with color illustrations and photographs, the book describes the possible application of molecular genetics to directed strain improvement in great detail. The needs for future developments in this field are also discussed at length Written by authorities in the field, Biosynthesis and Molecular Genetics of Fungal Secondary Metabolites provides a cutting-edge perspective on fungal secondary metabolism and underlying genetics and is a valuable resource for scientists, researchers, and educators in the field of fungal biology.
| Author | : Susanne Zeilinger |
| Publisher | : Springer |
| Total Pages | : 263 |
| Release | : 2015-06-15 |
| Genre | : Science |
| ISBN | : 1493925318 |
Fungi produce many chemically diverse secondary metabolites whose biological roles largely remain elusive. Within the increasing number of sequenced fungal genomes several important genes involved in secondary metabolite formation have been identified. Most of these genes are clustered and their coordinated transcription is controlled in a complex way by both narrow pathway-specific regulators as well as broad global transcription factors responsive to environmental cues. In recent years it was discovered many of the newly identified gene clusters are silent under laboratory conditions suggesting that the biosynthetic potential of fungi is far from being exploited. Besides identifying novel bioactive metabolites from still unexplored sources, the activation of these gene clusters by several approaches may result in the discovery of new substances with antibiotic and pharmaceutical benefits. This book covers recent advances in the field of fungal secondary metabolisms ranging from methodologies to biological aspects and will include the latest knowledge on fungal molecular biology, genomics, and metabolomics. With the related volume by Professor Juan-Francisco Martin, where the most relevant and well-studied fungal secondary metabolites are compiled, this book provides a comprehensive overview of the state-of-the-art of research on fungal secondary metabolites.
| Author | : Sumita Jha |
| Publisher | : Springer |
| Total Pages | : 0 |
| Release | : 2019-07-24 |
| Genre | : Science |
| ISBN | : 9783319904832 |
This reference work presents an authoritative review of endophytes and their applications to human welfare. Endophytes have become a class of interesting and curious microorganisms due to their intimate intra- and intercellular association with plants for competence, survival and reproduction. They can be bacteria or fungi, and they are usually non-pathogenic to their host. Endophytes have important applications in agriculture and industry, namely, they can help with plant growth, act as biocontrol agents and biosurfactant and secondary metabolite producers, and they are also rich sources of bioactive natural products. Novel and beneficial effects of endophytes are constantly emerging, and this book, divided into four sections, provides readers with the latest developments in this fast expanding field. In the first section, readers will discover the biology of the major groups of endophytes, followed by a summary of conventional and molecular tools for endophytes’ identification in Section II. The production of high-value metabolites by endophytes will be explored in the third section of this book, and in the final section, readers will find several case studies, examples and prospects for endophytes’ application in agriculture and industry. Written by leading international authors, this reference work will appeal to a wide readership, from students and researchers in the field of botany, biotechnology and agriculture to professionals interested in the production and applications of endophytic metabolites.
| Author | : Jean-Michel Mérillon |
| Publisher | : Springer |
| Total Pages | : 0 |
| Release | : 2017-02-20 |
| Genre | : Science |
| ISBN | : 9783319250007 |
This handbook compiles authoritative information about fungal metabolites and their chemistry and biotechnology. The first in the reference work series “Phytochemicals”, and written by a team of international expert authors, this book provides reference information ranging from the description of fungal natural products, over their use e.g. as anticancer agents, to microbial synthesis, even spanning to the production of secondary metabolites on industrial scale. On the other hand it also describes global health issues related to aflatoxin production in foods and agriculture, including perspectives for detoxification. The handbook characterizes different compound classes derived from fungal secondary metabolites, like ergot alkaloids and aflatoxins. The discussion puts a special emphasis on how potentially useful compounds can be obtained and what applications they can find, on the one hand, and how potential dangers can be encountered on the other hand. The comprehensive chapters in this handbook will thus appeal to readers from diverse backgrounds in chemistry, biology, life sciences, and even medicine, who are working or planning to work with fungal (secondary) metabolites and their application. They provide the readers with rich sources of reference information on important topics in this field.
| Author | : Vijai Kumar Gupta |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 608 |
| Release | : 2012-12-09 |
| Genre | : Science |
| ISBN | : 1461423562 |
Laboratory Protocols in Fungal Biology presents the latest techniques in fungal biology. This book analyzes information derived through real experiments, and focuses on cutting edge techniques in the field. The book comprises 57 chapters contributed from internationally recognised scientists and researchers. Experts in the field have provided up-to-date protocols covering a range of frequently used methods in fungal biology. Almost all important methods available in the area of fungal biology viz. taxonomic keys in fungi; histopathological and microscopy techniques; proteomics methods; genomics methods; industrial applications and related techniques; and bioinformatics tools in fungi are covered and complied in one book. Chapters include introductions to their respective topics, list of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting. Each chapter is self-contained and written in a style that enables the reader to progress from elementary concepts to advanced research techniques. Laboratory Protocols in Fungal Biology is a valuable tool for both beginner research workers and experienced professionals. Coming Soon in the Fungal Biology series: Goyal, Manoharachary / Future Challenges in Crop Protection Against Fungal Pathogens Martín, García-Estrada, Zeilinger / Biosynthesis and Molecular Genetics of Fungal Secondary Metabolites Zeilinger, Martín, García-Estrada / Biosynthesis and Molecular Genetics of Fungal Secondary Metabolites, Volume 2 van den Berg, Maruthachalam / Genetic Transformation Systems in Fungi Schmoll, Dattenbock / Gene Expression Systems in Fungi Dahms / Advanced Microscopy in Mycology
| Author | : D. L. Hawksworth |
| Publisher | : Springer |
| Total Pages | : 158 |
| Release | : 1984-09-01 |
| Genre | : Science |
| ISBN | : 9780216916340 |
Lichen assocIations include some of the oldest living organisms and represent a major nutritional method adopted by one in five fungi. Major advances in our knowledge of these biologically fascinating organisms have been made in recent years and they now have a great deal to offer to teaching in colleges and universities. In addition to being examples of biotrophic systems, they merit discussion in courses on fungal phylogeny, fungal nutrition, ecology, ecophysiology, biogeography, evolution, chemo taxonomy, environmental monitoring, and algology. As all aspects of lichenology cannot be treated adequately in a book of this length, we have emphasized topics which we have found to be of particular interest to a advanced undergraduate and postgraduate biologists (or biogeographers) or those contemplating more detailed studies in particular areas. Consequently we have endeavoured to place lichen associations in the broader context of biological and biogeographical teaching. Examples are drawn from many areas of the world, including North America, but it is inevitable that European ones predominate, as lichens there are better known than in other regions. Technical terms are defined when first used, and definitions can therefore be located with the aid of the index. Lichens are not a systematic group and so are not appropriately treated in a groups-orientated programme, but are a major biological phenomenon all too commonly accorded scant attention in university courses.
| Author | : Bob B. Buchanan |
| Publisher | : John Wiley & Sons |
| Total Pages | : 1280 |
| Release | : 2015-08-31 |
| Genre | : Science |
| ISBN | : 0470714220 |
With over 1000 original drawings and 500 photographs, this work offers complete coverage of cell biology, plant physiology and molecular biology.
| Author | : Yasuji Asada |
| Publisher | : |
| Total Pages | : 388 |
| Release | : 1982 |
| Genre | : Botanical chemistry |
| ISBN | : |
| Author | : P. Vidhyasekaran |
| Publisher | : CRC Press |
| Total Pages | : 536 |
| Release | : 2007-08-09 |
| Genre | : Science |
| ISBN | : 1420021036 |
Dramatic progress in molecular biology and genetic engineering has recently produced an unparalleled wealth of information on the mechanisms of plant and pathogen interactions at the cellular and molecular levels. Completely revised and expanded, Fungal Pathogenesis in Plants and Crops: Molecular Biology and Host Defense Mechanisms, Second Edition
