Biosafety Concerns Involving Genetically Modified Mosquitoes To Combat Malaria And Dengue In Developing Countries
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| Author | : Brij Kishore Tyagi |
| Publisher | : |
| Total Pages | : 0 |
| Release | : 2021 |
| Genre | : |
| ISBN | : 9789811629655 |
This book comprehensively covers the latest development in developing and deploying the genetically modified vectors, particularly Anopheles and Aedes mosquitoes responsible for transmitting malaria parasites and dengue viruses, the most deadly and/or debilitating among all the vector-borne diseases. It is considered timely and commensurate to bring about a book dealing with the various ecological, biological and social as well as regulatory aspects for the deployment of genetically modified vectors in special context with the biosafety of humans, his associates, and the environment. Written by an array of specialists and experts in various subjects of genetically modified organisms, this book centrally addresses the (i) basic principles of the genetic manipulation of vectors and they are potential impact on human and the environment, (ii) ecological, biological, ethical, legal and social implications of the use of genetically modified vectors, (iii) identification of potential hazards; assessment and management of risks for human and environment; risk/benefit analysis, (iv) principles and practices for the assessment and management of biosecurity and biosafety in laboratories (and in the field), (v) guiding principles for creation and management of institutional or national biosafety review boards and ethics review committees, and (vi) development and application of a biosafety regulatory framework and its related legal principles at national levels for securing the development and use of vector control methods based on genetic modification strategies. This publication will be useful to researchers, scientists, and professionals engaged in academic and research institutions, government or non-government, as well as students in universities and medical colleges.
| Author | : |
| Publisher | : World Health Organization |
| Total Pages | : 196 |
| Release | : 2021-05-18 |
| Genre | : Medical |
| ISBN | : 9240025235 |
| Author | : Brij Kishore Tyagi |
| Publisher | : Springer |
| Total Pages | : 0 |
| Release | : 2022-12-15 |
| Genre | : Medical |
| ISBN | : 9789811629662 |
This book comprehensively covers the latest development in developing and deploying the genetically modified vectors, particularly Anopheles and Aedes mosquitoes responsible for transmitting malaria parasites and dengue viruses, the most deadly and/or debilitating among all the vector-borne diseases. It is considered timely and commensurate to bring about a book dealing with the various ecological, biological and social as well as regulatory aspects for the deployment of genetically modified vectors in special context with the biosafety of humans, his associates, and the environment. Written by an array of specialists and experts in various subjects of genetically modified organisms, this book centrally addresses the (i) basic principles of the genetic manipulation of vectors and they are potential impact on human and the environment, (ii) ecological, biological, ethical, legal and social implications of the use of genetically modified vectors, (iii) identification of potential hazards; assessment and management of risks for human and environment; risk/benefit analysis, (iv) principles and practices for the assessment and management of biosecurity and biosafety in laboratories (and in the field), (v) guiding principles for creation and management of institutional or national biosafety review boards and ethics review committees, and (vi) development and application of a biosafety regulatory framework and its related legal principles at national levels for securing the development and use of vector control methods based on genetic modification strategies. This publication will be useful to researchers, scientists, and professionals engaged in academic and research institutions, government or non-government, as well as students in universities and medical colleges.
| Author | : Zach N. Adelman |
| Publisher | : Academic Press |
| Total Pages | : 487 |
| Release | : 2015-10-15 |
| Genre | : Medical |
| ISBN | : 0128004053 |
Genetic Control of Malaria and Dengue focuses on the knowledge, technology, regulation and ethics of using genetically modified mosquitoes to interrupt the transmission of important vector-borne diseases including Malaria. It contains coverage of the current state of knowledge of vector-borne diseases and how they are currently controlled; vaccine, drug and insecticide development; various strategies for altering the genome of mosquitoes in beneficial ways; and the regulatory, ethical and social environment concerning these strategies. For more than five decades, the prospect of using genetically-modified mosquitoes to control vector-borne disease transmission has been a purely hypothetical scenario. We simply did not have the technology or basic knowledge to be able to do it. With the explosion of field trials and potential interventions in development, Genetic Control of Malaria and Dengue provides a comprehensive overview of research in genetics, microbiology, virology, and ecology involved in the development and implementation of genetic modification programs for virus and disease control. This book is meant to provide a practical guide to researchers, regulators and the general public about how this technology actually works, how it can be improved, and what is still unknown. - Includes coverage of vectorial capacity, critical to understanding vector-borne disease transmission - Provides a summary of the concepts of both population suppression and population replacement - Contains pivotal coverage of ethical and ecological ramifications of genetics-based control strategies
| Author | : National Academies of Sciences, Engineering, and Medicine |
| Publisher | : National Academies Press |
| Total Pages | : 231 |
| Release | : 2016-08-28 |
| Genre | : Science |
| ISBN | : 0309437873 |
Research on gene drive systems is rapidly advancing. Many proposed applications of gene drive research aim to solve environmental and public health challenges, including the reduction of poverty and the burden of vector-borne diseases, such as malaria and dengue, which disproportionately impact low and middle income countries. However, due to their intrinsic qualities of rapid spread and irreversibility, gene drive systems raise many questions with respect to their safety relative to public and environmental health. Because gene drive systems are designed to alter the environments we share in ways that will be hard to anticipate and impossible to completely roll back, questions about the ethics surrounding use of this research are complex and will require very careful exploration. Gene Drives on the Horizon outlines the state of knowledge relative to the science, ethics, public engagement, and risk assessment as they pertain to research directions of gene drive systems and governance of the research process. This report offers principles for responsible practices of gene drive research and related applications for use by investigators, their institutions, the research funders, and regulators.
| Author | : W. Takken |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 248 |
| Release | : 2003-07-31 |
| Genre | : Science |
| ISBN | : 9781402015854 |
This book is the reflection of a workshop, held in June 2002. Experts on mosquito ecology met for the first time to discuss the current knowledge of mosquito ecology with respect to GM-insect technology. Emphasis of the workshop was on evaluating how human health and natural ecosystems, including target wild-mosquito populations, will respond to the invasion of GM vectors. This volume will stimulate discussion by clearly showing the importance of vector ecology for prevention of vector-borne diseases.
| Author | : Institute of Medicine |
| Publisher | : National Academies Press |
| Total Pages | : 312 |
| Release | : 1991-02-01 |
| Genre | : Medical |
| ISBN | : 9780309045278 |
Malaria is making a dramatic comeback in the world. The disease is the foremost health challenge in Africa south of the Sahara, and people traveling to malarious areas are at increased risk of malaria-related sickness and death. This book examines the prospects for bringing malaria under control, with specific recommendations for U.S. policy, directions for research and program funding, and appropriate roles for federal and international agencies and the medical and public health communities. The volume reports on the current status of malaria research, prevention, and control efforts worldwide. The authors present study results and commentary on the: Nature, clinical manifestations, diagnosis, and epidemiology of malaria. Biology of the malaria parasite and its vector. Prospects for developing malaria vaccines and improved treatments. Economic, social, and behavioral factors in malaria control.
| Author | : I.W. Fong |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 326 |
| Release | : 2012-09-06 |
| Genre | : Medical |
| ISBN | : 1461444969 |
This next volume in the series will provide up to date Information and discussion on future approach to control several challenging Infectious Disease worldwide. The past decade has been highlighted by numerous advances in research of medical scientific knowledge. medical technology and the biological and diagnostic techniques-but somewhat less dramatic changes or improvement in management of medical conditions. This volume will address some of the emerging issues, challenges, and controversies in Infectious Diseases.
| Author | : World Health Organization |
| Publisher | : World Health Organization |
| Total Pages | : 316 |
| Release | : 2005 |
| Genre | : Medical |
| ISBN | : 9789241546164 |
This field manual is intended to help health professionals and public health coordinators working in emergency situations prevent, detect and control the major communicable diseases encountered by affected populations. The manual is the result of collaboration among a number of WHO departments and several external partner agencies in reviewing existing guidelines on communicable disease control and adapting them to emergency situations. The manual deals with the fundamental principles of communicable disease control in emergencies, which are: Rapid assessment to identify the communicable disease threats faced by the emergency-affected population, including those with epidemic potential, and define the health status of the population by conducting a rapid assessment; Prevention to prevent communicable disease by maintaining a healthy physical environment and good general living conditions; Surveillance to set up or strengthen disease surveillance system with an early warning mechanism to ensure the early reporting of cases to monitor disease trends, and to facilitate prompt detection and response to outbreaks; outbreak control to ensure outbreaks are rapidly detected and controlled through adequate preparedness (i.e. stockpiles, standard treatment protocols and staff training) and rapid response (i.e.confirmation, investigation and implementation of control measures); and disease management to diagnose and treat cases promptly with trained staff using effective treatment and standard protocols at all health facilities.
| Author | : Jerome Goddard |
| Publisher | : CRC Press |
| Total Pages | : 323 |
| Release | : 2022-03-10 |
| Genre | : Science |
| ISBN | : 1000543013 |
In the struggle against vector-borne diseases, it is critical that we bridge the gap among vector control workers on the ground (practitioners), public health planners and administrators, and (academic) medical entomologists. This second edition of Public Health Entomology is designed to fit certificate courses in public health entomology offered by universities and U.S. Centers of Excellence. It comprehensively examines vector-borne disease prevention, surveillance, and control from a governmental and public health perspective with worldwide application. Divided into two sections, the book begins with a historical account of the early beginnings of pest control and public health. Next, it outlines the concepts, design, and implementation of a sound public health entomology program, including issues associated with pesticide use, FEMA and other disaster response entities, and an adverse, chemophobic public. The second section provides an overview of some of the most common public health pests that are found globally. Copious photos and line drawings accentuate the text, along with text boxes and sidebars. The new edition addresses "IPM and Alternative Control Methods" in each section, expands the Lyme disease section, and includes other new and emerging tick-borne diseases (TBD). It provides enhanced discussion of working with local political figures and jurisdictions, as well as partnerships with academia, and is generally more worldwide in scope. Author Jerome Goddard designed and implemented the vector control program along the Mississippi Gulf Coast after Hurricane Katrina. His ability to communicate his knowledge and experience to public health students, professionals, and the general public make this book an essential resource for preventing disease from these vector-borne threats.
