Biomarkers Of Cardiometabolic Risk Inflammation And Disease
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Author | : Filipe Palavra |
Publisher | : Springer |
Total Pages | : 172 |
Release | : 2015-04-11 |
Genre | : Medical |
ISBN | : 3319160184 |
This book discusses recent advances in the area of cardiometabolic risk biomarkers of chronic inflammatory and cardiovascular disorders. Tackling the topic in a systematic manner, the book starts with an introduction to cardiometabolic risk and its clinical relevance, comparing emergent and classical biomarkers. It then goes on to discuss cardiometabolic risk biomarkers in a range of diseases, including diabetes, ischemic stroke and neurodegenerative disorders. Biomarkers of Cardiometabolic Risk, Inflammation and Disease is aimed at doctors specializing in internal medicine, neurology, cardiology, rheumatology, nephrology or endocrinology and will also be of interest to GPs, trainee doctors and clinical and basic researchers working on cardiovascular and autoimmune disorders.
Author | : Vijay Nambi |
Publisher | : Elsevier Health Sciences |
Total Pages | : 199 |
Release | : 2018-11-27 |
Genre | : Medical |
ISBN | : 0323548369 |
Get a quick, expert overview of the ways in which biomarkers can be used to assess and guide the management of cardiovascular disease in the clinical setting. This concise, clinically-focused resource by Dr. Vijay Nambi consolidates today's available information on this rapidly changing topic into one convenient resource, making it an ideal, easy-to-digest reference for cardiology practitioners, fellows, and residents. - Covers lab standards and statistical interpretation of biomarkers with a clinical focus. - Discusses relevant conditions such as hypertension and diabetes as key markers of injury and prognosis. - Includes current information on biomarkers to assess and guide the management of heart failure, acute coronary syndrome, chest pain, shortness of breath, and more. - Concludes the book with a timely chapter on how biomarkers may guide cardiologists in the future.
Author | : Dimitris Tousoulis |
Publisher | : CRC Press |
Total Pages | : 452 |
Release | : 2013-07-29 |
Genre | : Medical |
ISBN | : 1466587148 |
The establishment of precise and reliable biomarker tests for the early stages of cardiovascular disease is of great importance and can be the cornerstone in the prevention of future cardiovascular disease (CVD). Furthermore, some biomarkers may provide important information concerning the pathogenesis of CVD or appear to be useful in risk stratification, in CVD diagnosis, or in monitoring therapy; many others may be risk factors themselves, representing therefore potential targets of therapy. The ideal biomarker should have the following characteristics: highly sensitive, specific, reliable, accessible, standardized, dependable, cost effective, and easily interpretable by clinicians. The present book focuses on the presentation and evaluation of the most promising classical and novel biochemical markers used in CVD (coronary artery disease, hypertension, heart failure, hyperlipidemia, peripheral arterial disease). The underlying pathophysiological characteristics of each biomarker, as well as potential clinical implications in daily practice are reviewed in this book.
Author | : Bibiana Garcia Bailo |
Publisher | : |
Total Pages | : |
Release | : 2013 |
Genre | : |
ISBN | : |
Author | : James L. Januzzi |
Publisher | : Jones & Bartlett Learning |
Total Pages | : 922 |
Release | : 2011 |
Genre | : Medical |
ISBN | : 0763761613 |
Cardiac Biomarkers in Clinical Practice was just honored with 4 Stars from Doody's Book Review! Cardiac Biomarkers in Clinical Practice presents a case based approach to biomarkers in heart diseases including heart failure, ischemic heart disease, and outpatient. Divided into six sections, this book provides physicians and other health care providers with a clear understanding of the role of biomarkers in clinical cardiovascular medicine.
Author | : Mirjana Macvanin |
Publisher | : Frontiers Media SA |
Total Pages | : 100 |
Release | : 2024-08-22 |
Genre | : Medical |
ISBN | : 2832553494 |
Cardiometabolic disease (CMD) represents the major cause of mortality, accounting for one-third of all global deaths, 75% of which occur in middle- and low-income countries. CMD encompasses a broad spectrum of conditions characterized by limited prediction, based mainly on classical risk factors due to a lack of accurate molecular CMD predictors. Thus, there is an urgent need for improved diagnostics solutions to support early intervention and improve outcomes. Early detection and adequate intervention are crucial to prevent CMD-associated complications, encouraging the quest for appropriate biomarkers with diverse applications ranging from risk assessment and screening to diagnosis and prognosis. Different circulating biomarkers for quantifying the CMD risk have been reported in the literature, such as C-reactive protein (CRP), leptin, and adiponectin. In addition, accumulating evidence in the literature points to the emergence of novel CMD biomarkers, such as cytokines, various metabolites, apelin, microRNAs, inflammasome molecules, and cardiac fibrosis markers. However, large meta-analyses have not sufficiently investigated and confirmed their biological roles in CMD diagnosis, prognosis, and/or potential reduction.
Author | : Mu Wang |
Publisher | : BoD – Books on Demand |
Total Pages | : 262 |
Release | : 2016-08-17 |
Genre | : Medical |
ISBN | : 9535125052 |
The use of biomarkers in basic and clinical research has become routine in many areas of medicine. They are accepted as molecular signatures that have been well characterized and repeatedly shown to be capable of predicting relevant disease states or clinical outcomes. In Role of Biomarkers in Medicine, expert researchers in their individual field have reviewed many biomarkers or potential biomarkers in various types of diseases. The topics address numerous aspects of medicine, demonstrating the current conceptual status of biomarkers as clinical tools and as surrogate endpoints in clinical research. This book highlights the current state of biomarkers and will aid scientists and clinicians to develop better and more specific biomarkers for disease management.
Author | : Benedicte Fontaine-Bisson |
Publisher | : |
Total Pages | : 294 |
Release | : 2008 |
Genre | : |
ISBN | : 9780494398890 |
Chronic inflammation is a common feature of obesity, type 2 diabetes and cardiovascular disease. Nuclear factor kappa B (NF-kappaB) is a transcription factor that plays a central role in inflammation by regulating the expression of a number of important genes, such as the major pro-inflammatory cytokine tumor necrosis factor (TNF)-alpha. Both NF-kappaB and TNF-alpha have been implicated in the pathogenesis of insulin resistance and the development of a pro-atherogenic lipid profile. Their production can be modulated by dietary polyunsaturated fatty acids (PUFAs), from both the n-3 and n-6 series, as well as by genetic variations that alter transcriptional activity. The objective of this thesis was to determine whether common variations in major genes regulating inflammation (NF-kappaB and TNF-alpha) modify the association between dietary PUFAs intake and biomarkers of cardiovascular disease in two different populations. In summary, the NF-kappaB -49Ins/Del ATTG and TNF-alpha -238G>A and -308 G>A polymorphisms modify the association between dietary PUFAs intake and plasma HDL-cholesterol in two different populations. Taken together, these findings suggest that inflammation may mediate the effect of dietary PUFAs on the reverse cholesterol transport and impact the risk of cardiovascular disease. The first population involved overweight or obese men and women (n=109) aged 42--75 years with type 2 diabetes. The second population involved mostly lean and healthy men and women (n=595) aged 20--29 years. Subjects were genotyped for the NF-kappaB -49Ins/Del ATTG and for the TNF-alpha -238G>A and -308G>A polymorphisms. Dietary intake was assessed using either a 3-day food record or a food frequency questionnaire. Among individuals with type 2 diabetes, the association between dietary PUFAs intake and plasma HDL-cholesterol concentrations was modified by variations in both the NF-kappaB and TNF-alpha genes. The association between PUFAs intake and HDL-cholesterol was either positive, inverse or null, depending on the particular NF-kappaB and TNF-alpha genotype. In the population of young adults, genetic variations in both the NF-kappaB and TNF-alpha genes also modified the association between dietary PUFAs intake and plasma HDL-cholesterol. NF-kappaB and TNF-alpha genotypes did not modify the association between other dietary fatty acids and other plasma lipids in either population.
Author | : Philip Peplow |
Publisher | : Royal Society of Chemistry |
Total Pages | : 396 |
Release | : 2015-05-22 |
Genre | : Medical |
ISBN | : 178262046X |
Cardiovascular and metabolic diseases remain the number one cause of death in developed countries and their prevalence is increasing rapidly in developing nations. This book brings together the recent information on these disorders and the links that exist between them in order to provide a complete picture of drug discovery for these conditions. The main three sections comprehensively discuss obesity, hypertension and cardiovascular disease, and diabetes in turn, following an introduction to the molecular links between them. The final chapter provides perspectives on future directions of the field. Chapters are contributed by leaders in the field from academia and industry and cover biomarkers, risk factors, gene-environment interactions, therapies and the various types of animal models that have been used to study each disease. Case studies describing the implementation of animal models in drug development further enhance the book’s usefulness as a comprehensive guide to this important therapeutic area. Providing a full picture of the various types of animal models that have been used to study obesity, hypertension, and insulin resistance with recent case studies, this book provides a valuable resource for medicinal chemists and clinicians working in these disease areas.
Author | : Yuli Huang |
Publisher | : Frontiers Media SA |
Total Pages | : 249 |
Release | : 2022-10-21 |
Genre | : Medical |
ISBN | : 2832503136 |