Biology Of The Nmda Receptor
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Author | : Antonius M. VanDongen |
Publisher | : CRC Press |
Total Pages | : 368 |
Release | : 2008-10-29 |
Genre | : Medical |
ISBN | : 142004415X |
The NMDA receptor plays a critical role in the development of the central nervous system and in adult neuroplasticity, learning, and memory. Therefore, it is not surprising that this receptor has been widely studied. However, despite the importance of rhythms for the sustenance of life, this aspect of NMDAR function remains poorly studied. Written
Author | : Edward D. Levin |
Publisher | : CRC Press |
Total Pages | : 395 |
Release | : 2006-06-22 |
Genre | : Medical |
ISBN | : 1420004336 |
The costs associated with a drug's clinical trials are so significant that it has become necessary to validate both its safety and efficacy in animal models prior to the continued study of the drug in humans. Featuring contributions from distinguished researchers in the field of cognitive therapy research, Animal Models of Cognitive Impairmen
Author | : G. L. Collingridge |
Publisher | : Oxford University Press, USA |
Total Pages | : 503 |
Release | : 1994 |
Genre | : Medical |
ISBN | : 9780192623713 |
Fingerprint Wizards is a Capstone Press publication.
Author | : Scott L. Zeller |
Publisher | : Cambridge University Press |
Total Pages | : 297 |
Release | : 2017-02-15 |
Genre | : Medical |
ISBN | : 110714812X |
A practical guide to the origins and treatment options for agitation, a common symptom of psychiatric and neurologic disorders.
Author | : Dalip J.S. Sirinathsinghji |
Publisher | : Birkhäuser |
Total Pages | : 212 |
Release | : 2012-11-28 |
Genre | : Medical |
ISBN | : 3034881398 |
There is now considerable preclinical evidence that glutamate acting via the NMDA receptor is involved in the transmission of nociceptive information and in the triggering mechanisms for hyperalgesia and allodynia. This evidence allows rational development of a new class of analgesic drugs that act as antagonists of the NMDA receptor, supported by emerging evidence with existing excitatory amino acid antagonists. Leading scientists in excitatory amino acid and analgesia research have compiled in this volume the most recent information on molecular biology, physiology and pharmacology of NMDA receptors, their neuroanatomical localisation within specific neural pathways involved in nociception, and experimental and clinical evidence demonstrating the potential of receptor antagonists of NMDA and other excitatory amino acids in the treatment of pain states.
Author | : Toshiyuki Fukada |
Publisher | : Springer Nature |
Total Pages | : 412 |
Release | : 2019-12-13 |
Genre | : Medical |
ISBN | : 9811505578 |
This book, now in an extensively revised second edition, describes the crucial role of zinc signaling in biological processes on a molecular and physiological basis. Global leaders in the field review the latest knowledge, including the very significant advances in understanding that have been achieved since publication of the first edition. Detailed information is provided on all the essentials of zinc signaling, covering molecular aspects and the roles of zinc transporters, the zinc sensing receptor, and metallothioneins. Detection techniques for zinc signals, involving genetically encoded and chemical probes, are also described. The critical contributions of the zinc signal in maintaining health and the adverse consequences of any imbalance in the signal are then thoroughly addressed. Here, readers will find up-to-date information on the significance of the zinc signal in a wide range of conditions, including cardiovascular disorders, neurodegenerative diseases, diabetes, autoimmune diseases, inflammatory conditions, skin disease, osteoarthritis, and cancer. The book will be of value for researchers, clinicians, and advanced students.
Author | : Raymond S. Sinatra |
Publisher | : Cambridge University Press |
Total Pages | : 551 |
Release | : 2010-10-14 |
Genre | : Medical |
ISBN | : 1139491989 |
The Essence of Analgesia and Analgesics is an invaluable practical resource for clinicians giving pain relief in any clinical setting, describing the pharmacologic principles and clinical use of all available pain medications. As well as detailed overviews of pain processing and analgesic theory, sections are dedicated to oral and panteral opioid analgesics, neuraxial opioids, NSAIDs, local anesthetics, anticonvulsant type analgesics, NMDA antagonists, alpha adrenergic analgesics, antidepressant analgesics, muscle relaxants, adjuvant medications, and new and emerging analgesics. The concise format of the chapters allows for quick and easy reading and assimilation of information. Enhanced by summary tables and figures, each chapter provides an overview of a particular drug, covering chemical structure, mode of activity, indications, contraindications, common doses and uses, advantages and disadvantages, and drug related adverse events. Key references are also provided. Edited by leading experts in pain management, this is essential reading for any clinician involved in pain management.
Author | : Maria Teresa Gentile |
Publisher | : BoD – Books on Demand |
Total Pages | : 244 |
Release | : 2018-03-21 |
Genre | : Medical |
ISBN | : 9535138855 |
A team of authors from prestigious academic schools contributed to draw up a project that would give a detailed account of astrocyte's morphology and physiology, examining thoroughly all the astrocyte's types; giving an accurate description of their morphology, location, function in the brain; and illustrating their physiology and pathology in terms of dealing with neurons through "gliotransmitters," ionic channels, and membrane receptors expression. This book gives an overview of the crucial role of astrocytes in the physiology of the CNS and in the pathogenesis of several CNS disorders suggesting that the shift from a neurocentric view to one that incorporates astrocytes in disease models for drug discovery is a critical step in renewing drug development strategies to treat neurodegenerative diseases.
Author | : Wulfram Gerstner |
Publisher | : Cambridge University Press |
Total Pages | : 591 |
Release | : 2014-07-24 |
Genre | : Computers |
ISBN | : 1107060834 |
This solid introduction uses the principles of physics and the tools of mathematics to approach fundamental questions of neuroscience.
Author | : |
Publisher | : Academic Press |
Total Pages | : 404 |
Release | : 2020-06-29 |
Genre | : Medical |
ISBN | : 0128201908 |
The Advances in Pharmacology series presents a variety of chapters from the best authors in the field. Includes the authority and expertise of leading contributors in pharmacology Presents the latest release in the Advances in Pharmacology series