Biological Mass Spectrometry
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| Author | : A.L. Burlingame |
| Publisher | : Gulf Professional Publishing |
| Total Pages | : 520 |
| Release | : 2005-11-28 |
| Genre | : Science |
| ISBN | : 9780121828073 |
Describes and integrates the techniques of many advances in both chromatographic and mass spectrometric technologies. This book also covers various biophysical applications, such as H/D exchange for study of conformations, protein-protein and protein-metal and ligand interactions. It also describes atto-to-zepto-mole quantitation of 14C and 3H.
| Author | : Alexander R. Ivanov |
| Publisher | : Springer |
| Total Pages | : 1089 |
| Release | : 2013-01-02 |
| Genre | : Science |
| ISBN | : 9789400708297 |
The aim of this book is to provide the researcher with important sample preparation strategies in a wide variety of analyte molecules, specimens, methods, and biological applications requiring mass spectrometric analysis as a detection end-point. In this volume we have compiled the contributions from several laboratories which are employing mass spectrometry for biological analysis. With the latest inventions and introduction of highly sophisticated mass spectrometry equipment sample preparation becomes an extremely important bottleneck of biomedical analysis. We have a goal of giving the reader several successful examples of sample preparation, development and optimization, leading to the success in analytical steps and proper conclusions made at the end of the day. This book is structured as a compilation of contributed chapters ranging from protocols to research articles and reviews. The main philosophy of this volume is that sample preparation methods have to be optimized and validated for every project, for every sample type and for every downstream analytical technique.
| Author | : T. Matsuo |
| Publisher | : |
| Total Pages | : 698 |
| Release | : 1994-05-10 |
| Genre | : Science |
| ISBN | : |
Prominent active researchers present comprehensive reviews of modern biological mass spectrometry (BMS) including an excellent introduction to the instrumentation and applications currently being implemented. Profiles such recent techniques as ESI, MALDI, LC/MS, Ion-Trap and FT/ICR. Contains specific applications to proteins, drugs and natural products. Features practical guidance for problem solving within the biological sciences. Provides a detailed record of BMS in the early 90s which will serve as a reference in years to come.
| Author | : A. L. Burlingame |
| Publisher | : |
| Total Pages | : 700 |
| Release | : 1990 |
| Genre | : |
| ISBN | : |
| Author | : Pradip K. Ghosh |
| Publisher | : Academic Press |
| Total Pages | : 313 |
| Release | : 2015-12-10 |
| Genre | : Science |
| ISBN | : 0128021128 |
Introduction to Protein Mass Spectrometry provides a comprehensive overview of this increasingly important, yet complex, analytical technique. Unlike many other methods which automatically yield an absolutely unique protein name as output, protein mass spectrometry generally requires a deduction of protein identity from determination of peptide fragmentation products. This book enables readers to both understand, and appreciate, how determinations about protein identity from mass spectrometric data are made. Coverage begins with the technical basics, including preparations, instruments, and spectrometric analysis of peptides and proteins, before exploring applied use in biological applications, bioinformatics, database, and software resources. Citing the most recent and relevant work in the field of biological mass spectrometry, the book is written for researchers and scientists new to the field, but is also an ideal resource for those hoping to hone their analytical abilities. Offers introductory information for scientists and researchers new to the field, as well as advanced insight into the critical assessment of computer-analyzed mass spectrometric results and their current limitations Provides examples of commonly-used MS instruments from Bruker, Applied Biosystems, JEOL, Thermo Scientific/Thermo Fisher Scientific, IU, and Waters Includes biological applications and exploration of analytical tools and databases for bioinformatics
| Author | : Alexander R. Ivanov |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 1081 |
| Release | : 2011-06-15 |
| Genre | : Science |
| ISBN | : 9400708289 |
The aim of this book is to provide the researcher with important sample preparation strategies in a wide variety of analyte molecules, specimens, methods, and biological applications requiring mass spectrometric analysis as a detection end-point. In this volume we have compiled the contributions from several laboratories which are employing mass spectrometry for biological analysis. With the latest inventions and introduction of highly sophisticated mass spectrometry equipment sample preparation becomes an extremely important bottleneck of biomedical analysis. We have a goal of giving the reader several successful examples of sample preparation, development and optimization, leading to the success in analytical steps and proper conclusions made at the end of the day. This book is structured as a compilation of contributed chapters ranging from protocols to research articles and reviews. The main philosophy of this volume is that sample preparation methods have to be optimized and validated for every project, for every sample type and for every downstream analytical technique.
| Author | : Chhabil Dass |
| Publisher | : John Wiley & Sons Incorporated |
| Total Pages | : 500 |
| Release | : 2016-03-28 |
| Genre | : Science |
| ISBN | : 9780470546024 |
This book provides professionals in the biological sciences with a solid basis in the fundamentals of contemporary mass spectrometry so that they can confidently choose and apply the best instrumentation and experimental approaches for their needs. The only single-volume guide of its kind, the book offers comprehensive coverage of various aspects of the latest instrumentation (including ionization methods, mass analyzers, detectors, tandem MS, and hyphenated techniques), techniques used in the analysis of important classes of biological materials such as peptides, proteins, lipids, carbohydrates, and oligonucleotides, and applications to real-world problems.
| Author | : M.L Gross |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 462 |
| Release | : 2012-12-06 |
| Genre | : Science |
| ISBN | : 9401126186 |
The developments in mass spectrometry over the past fifteen years have been impressive in their implications in bioanalytical chemistry. The achievements begin with the inventions of Cf-252 Plasma Desorption Mass Spectrometry by Macfarlane and Fourier Transform Mass Spectrometry by Comisarow and Marshall in the mid 1970s. The former showed the feasibility of producing large gas-phase ions from large biomolecules whereas the latter enhanced the capabilities for ion trapping especially in analytical mass spectrometry. A major achievement was the development by Barber of Fast Atom Bombardment (FAB) mass spectrometry, an advance that heralded a new era in biological mass spectrometry. Contemporary and routine instruments such as magnetic sectors and quadrupoles were rapidly adapted to F AB, and nearly the entire universe of small molecules became amenable to study by mass spectrometry. The introduction of FAB also paved the way for improvement of instrument capability. For example, the upper mass limit of magnet sector mass spectrometers was increased by nearly an order of magnitude by the instrument manufacturers. Furthermore, the technique of tandem mass spectrometry (MS/MS) was given new meaning because important structural information for biomolecules could now be produced for ions introduced by FAB into the tandem instrument. The evolution of MS/MS continues today with the development of ion traps, time-of-flight, and sector instruments equipped with array detection.
| Author | : Norberto Peporine Lopes |
| Publisher | : Royal Society of Chemistry |
| Total Pages | : 312 |
| Release | : 2017-11-16 |
| Genre | : Science |
| ISBN | : 1788013468 |
Mass spectrometry is one of the most widespread technologies in chemistry and has been increasingly used in biology with the rise of omics sciences. This book summarizes some important methodological approaches in mass spectrometry and applications in the field of chemical biology. The core chapters build on basic concepts introduced in the opening chapter and explore established fields such as high throughput screening, proteomics and metabolomics. Emerging applications of mass spectrometry in elucidating biosynthetic pathways, enzyme mechanisms and protein-protein interactions are then presented. Connections between these diverse research fields are highlighted throughout. The book concludes with a discussion of databases and future perspectives. This book will be a useful tool to early chemical biology researchers wishing to incorporate mass spectrometry as a tool in their research.
| Author | : Igor A. Kaltashov |
| Publisher | : John Wiley & Sons |
| Total Pages | : 312 |
| Release | : 2012-04-03 |
| Genre | : Science |
| ISBN | : 0470937793 |
The definitive guide to mass spectrometry techniques in biology and biophysics The use of mass spectrometry (MS) to study the architecture and dynamics of proteins is increasingly common within the biophysical community, and Mass Spectrometry in Structural Biology and Biophysics: Architecture, Dynamics, and Interaction of Biomolecules, Second Edition provides readers with detailed, systematic coverage of the current state of the art. Offering an unrivalled overview of modern MS-based armamentarium that can be used to solve the most challenging problems in biophysics, structural biology, and biopharmaceuticals, the book is a practical guide to understanding the role of MS techniques in biophysical research. Designed to meet the needs of both academic and industrial researchers, it makes mass spectrometry accessible to professionals in a range of fields, including biopharmaceuticals. This new edition has been significantly expanded and updated to include the most recent experimental methodologies and techniques, MS applications in biophysics and structural biology, methods for studying higher order structure and dynamics of proteins, an examination of other biopolymers and synthetic polymers, such as nucleic acids and oligosaccharides, and much more. Featuring high-quality illustrations that illuminate the concepts described in the text, as well as extensive references that enable the reader to pursue further study, Mass Spectrometry in Structural Biology and Biophysics is an indispensable resource for researchers and graduate students working in biophysics, structural biology, protein chemistry, and related fields.
