Bioinformatics of the Brain

Bioinformatics of the Brain
Author: Kayhan Erciyes
Publisher: CRC Press
Total Pages: 305
Release: 2024-09-25
Genre: Medical
ISBN: 1040117414

The brain consisting of billions of neurons is probably the most complex and mysterious organ of the body. Understanding the functioning of the brain in its health and disease states has baffled the researchers working in this area for many years. The diversity of brain diseases and disorders makes the analysis of brain functions an even more challenging area of research. In vitro and in vivo studies regarding the brain may be laborious, however, bioinformatics using in silico approaches may take the burden off the experimental studies and give us a clearer perspective on disease and healthy states of the brain, its functions, and disease mechanisms. Recent advancements in neuroimaging technologies, the development of high-performance computers and the development of software, algorithms and methods to analyze data obtained from various neuroimaging processes have opened new frontiers in neuroscience enabling unprecedented finer analysis of the brain functions. This relatively new approach of brain analysis which may be termed Bioinformatics of the Brain is the main subject of this volume aiming to provide a thorough review of various bioinformatics approaches for analyzing the functioning of the brain and understanding brain diseases such as neurodegenerative diseases, brain tumors, and neuropsychiatric disorders. Authors from various disciplines in this volume each focus on a different aspect aiming to expand our understanding of this area of research. Topics included are: Brain diseases and disorders Stem cell therapy of neurodegenerative diseases Tissue engineering applications of gliomas Brain tumor detection and modeling Brain tumor growth simulation Brain-computer interface Bioinformatics of brain diseases Graph-theoretical analysis of complex brain networks Brain proteomics This book is intended to aid scientists, researchers, and graduate students in carrying out interdisciplinary research in the areas of bioinformatics, bioengineering, computer engineering, software engineering, mathematics, molecular biology, genetics, and biotechnology.

Ecology of the Brain

Ecology of the Brain
Author: Thomas Fuchs
Publisher: Oxford University Press
Total Pages: 371
Release: 2018
Genre: Philosophy
ISBN: 0199646880

Present day neuroscience places the brain at the centre of study. But what if researchers viewed the brain not as the foundation of life, rather as a mediating organ? Ecology of the Brain addresses this very question. It considers the human body as a collective, a living being which uses the brain to mediate interactions. Those interactions may be both within the human body and between the human body and its environment. Within this framework, the mind is seen not as a product of the brain but as an activity of the living being; an activity which integrates the brain within the everyday functions of the human body. Going further, Fuchs reformulates the traditional mind-brain problem, presenting it as a dual aspect of the living being: the lived body and the subjective body - the living body and the objective body. The processes of living and experiencing life, Fuchs argues, are in fact inextricably linked; it is not the brain, but the human being who feels, thinks and acts. For students and academics, Ecology of the Brain will be of interest to those studying or researching theory of mind, social and cultural interaction, psychiatry, and psychotherapy.

Evolving Connectionist Systems

Evolving Connectionist Systems
Author: Nikola K. Kasabov
Publisher: Springer Science & Business Media
Total Pages: 465
Release: 2007-08-23
Genre: Computers
ISBN: 1846283477

This second edition of the must-read work in the field presents generic computational models and techniques that can be used for the development of evolving, adaptive modeling systems, as well as new trends including computational neuro-genetic modeling and quantum information processing related to evolving systems. New applications, such as autonomous robots, adaptive artificial life systems and adaptive decision support systems are also covered.

Databasing the Brain

Databasing the Brain
Author: Steven H. Koslow
Publisher:
Total Pages: 488
Release: 2005-03-10
Genre: Medical
ISBN:

Covers both basic principles and specific applications across a range of problems in brain research. It truly integrates neuroscience with informatics, providing a means for understanding the new analytical tools and models of neuronal functions now being developed. Each chapter offers practical guidance for applying this knowledge to current research, enhancing electronic collaborations, and formulating hypotheses.

Neuronal Guidance

Neuronal Guidance
Author: Marc Tessier-Lavigne
Publisher:
Total Pages: 0
Release: 2011
Genre: Medical
ISBN: 9780879698973

During the development of the brain growing nerves send out neuronal processes (axons and dendrites) that connect them to other nerve cells, sensory organs, and muscle tissue. Correct targeting of these is the basis for wiring of the entire nervous system and depends on attractive and repulsive molecular cues that guide the developing neurons to the appropriate destination. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology examines the mechanisms underlying neuronal guidance and branching and their roles in the development and function of the nervous system. The contributors examine the major guidance cues and their receptors, the intracellular signaling pathways they activate, and their function in the context of important phenomena such as laminar organization and dendrite spacing. Other chapters consider the roles of guidance cues in development of neuronal circuits dedicated to the processing of particular sensory stimuli, such as the visual and olfactory systems. In addition, they cover the roles played by guidance cues and their receptors in neuronal regeneration and human genetic disorders, revealing important clinical implications of work in this field. The book also contains chapters discussing the function of guidance molecules in other processes, such as neuronal cell body migration, axon pruning, and regulation of neuronal cell death. In addition, it explores their roles outside the nervous system for example, in development of the vasculature. This volume is thus of general interest to cell and developmental biologists, as well as all neurobiologists interested in how the nervous system develops and functions.

Bioinformatics and Computational Biology

Bioinformatics and Computational Biology
Author: Basant K. Tiwary
Publisher: Springer Nature
Total Pages: 239
Release: 2021-11-23
Genre: Medical
ISBN: 9811642419

This textbook introduces fundamental concepts of bioinformatics and computational biology to the students and researchers in biology, medicine, veterinary science, agriculture, and bioengineering . The respective chapters provide detailed information on biological databases, sequence alignment, molecular evolution, next-generation sequencing, systems biology, and statistical computing using R. The book also presents a case-based discussion on clinical, veterinary, agricultural bioinformatics, and computational bioengineering for application-based learning in the respective fields. Further, it offers readers guidance on reconstructing and analysing biological networks and highlights computational methods used in systems medicine and genome-wide association mapping of diseases. Given its scope, this textbook offers an essential introductory book on bioinformatics and computational biology for undergraduate and graduate students in the life sciences, botany, zoology, physiology, biotechnology, bioinformatics, and genomic science as well as systems biology, bioengineering and the agricultural, and veterinary sciences.

Micro-, Meso- and Macro-Dynamics of the Brain

Micro-, Meso- and Macro-Dynamics of the Brain
Author: György Buzsáki
Publisher: Springer
Total Pages: 181
Release: 2016-05-02
Genre: Medical
ISBN: 3319288024

This book brings together leading investigators who represent various aspects of brain dynamics with the goal of presenting state-of-the-art current progress and address future developments. The individual chapters cover several fascinating facets of contemporary neuroscience from elementary computation of neurons, mesoscopic network oscillations, internally generated assembly sequences in the service of cognition, large-scale neuronal interactions within and across systems, the impact of sleep on cognition, memory, motor-sensory integration, spatial navigation, large-scale computation and consciousness. Each of these topics require appropriate levels of analyses with sufficiently high temporal and spatial resolution of neuronal activity in both local and global networks, supplemented by models and theories to explain how different levels of brain dynamics interact with each other and how the failure of such interactions results in neurologic and mental disease. While such complex questions cannot be answered exhaustively by a dozen or so chapters, this volume offers a nice synthesis of current thinking and work-in-progress on micro-, meso- and macro- dynamics of the brain.

Divided Brains

Divided Brains
Author: Lesley J. Rogers
Publisher: Cambridge University Press
Total Pages: 241
Release: 2013-01-17
Genre: Medical
ISBN: 1107005353

Discusses brain asymmetry from four perspectives - function, evolution, development and causation - covering a wide range of species, including humans.

Neuroinformatics for Neuropsychology

Neuroinformatics for Neuropsychology
Author: Vinoth Jagaroo
Publisher: Springer Science & Business Media
Total Pages: 133
Release: 2009-08-11
Genre: Psychology
ISBN: 1441900608

Bioinformatics involves specialized application of computer technology to investigative and conceptual problems in biology and medicine; neuroinformatics (NI) is the practice of bioinformatics in the neurosciences. Over the past two decades the biomedical sciences have been revolutionized by databases, data mining and data modeling techniques. The Human Genome Project, which depended on informatics methods, has been the most well recognized bioinformatics undertaking. Bioinformatics has since been applied all across biology and medicine, and has also transformed almost every avenue in neuroscience. Yet in neuropsychology, NI perspectives remain largely unrealized. Ironically, NI offers enormous potential to the essential praxis of neuropsychology - assessing cognitive behavior and relating cognition to neural systems. Neuroinformatics can be applied to neuropsychology as richly as it has been applied across the neurosciences. Neuroinformatics for Neuropsychology is the first book to explain the relevance and value of NI to neuropsychology. It systematically describes NI tools, applications and models that can enhance the efforts of neuropsychologists. It also describes the implications of NI for neuropsychology in the 21st century – fundamental shifts away from the conventional modes of research, practice and communication that have thus far characterized the field. One of the foremost experts on the subject: Illustrates the vital role NI is playing throughout the neurosciences. Provides a sampling of NI tools and applications in neuroscience research, and lays out current organization structures that support NI. Describes the lack of NI in neuropsychology, differentiates between NI systems for neuropsychology and conventional computerized assessment methods, and proposes criteria for neuropsychology-specific NI systems. Describes NI applications and models currently in use in neuropsychology, and NI models for neuropsychology that are being pioneered in phenomics research. Discusses potential obstacles and aids to NI in neuropsychology, including issues such as data sharing, standardization of methods, and data ontology. Projects the future of neuropsychological research and practice in light of the new generation of the internet, Web 2.0, geared to collective knowledge building. A vital introduction to a profound technological practice, Neuroinformatics for Neuropsychology is important reading for clinical neuropsychologists, cognitive neuroscientists, behavioral neurologists, and speech-language pathologists. Researchers, clinicians, and graduate students interested in informatics for the brain-behavioral sciences will especially welcome this unique volume.

Data Analytics in Bioinformatics

Data Analytics in Bioinformatics
Author: Rabinarayan Satpathy
Publisher: John Wiley & Sons
Total Pages: 433
Release: 2021-01-20
Genre: Computers
ISBN: 111978560X

Machine learning techniques are increasingly being used to address problems in computational biology and bioinformatics. Novel machine learning computational techniques to analyze high throughput data in the form of sequences, gene and protein expressions, pathways, and images are becoming vital for understanding diseases and future drug discovery. Machine learning techniques such as Markov models, support vector machines, neural networks, and graphical models have been successful in analyzing life science data because of their capabilities in handling randomness and uncertainty of data noise and in generalization. Machine Learning in Bioinformatics compiles recent approaches in machine learning methods and their applications in addressing contemporary problems in bioinformatics approximating classification and prediction of disease, feature selection, dimensionality reduction, gene selection and classification of microarray data and many more.