Barriers And Channels Formed By Tight Junction Proteins Ii Volume 1258
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| Author | : Kirk L. Hamilton |
| Publisher | : Springer Nature |
| Total Pages | : 390 |
| Release | : 2020-12-12 |
| Genre | : Medical |
| ISBN | : 3030553108 |
This book discusses the unique ion channels and transporters found within the epithelial tissues of various organs, including the kidney, intestine, pancreas and respiratory tract. Authors focus on demonstrating the crucial roles that each of these channels and transporters play in transepithelial ion and fluid transport across epithelia, as well as in maintaining homeostasis. It allows readers to gain an understanding of the fundamentals of ion transport, in terms of function, modelling, regulation, trafficking, structure and pharmacology. This is the second of three volumes highlighting the importance of epithelial ion channels and transporters in basic physiology and pathophysiology of human diseases. This volume focuses on a wide array of epithelial tissues and the use of organoids to study epithelial function. Furthermore, clinical researchers and basic scientists from various fields provide a medical perspective on the physiology of a number of tissues and organs of the body including the pancreas, intestine, sweat glands, mammary gland, inner ear epithelia, retinal pigment epithelia of the eye, choroid plexus, and the ectodermal epithelia in dental enamel formation. This volume aims to ‘round out’ the reader’s journey from basic science to the laboratory bench and clinical management of molecular diseases, making Volume 2 a must-read for students and scientists in the field of physiology, as well as for clinicians.
| Author | : Gert Fricker |
| Publisher | : Springer |
| Total Pages | : 169 |
| Release | : 2014-10-24 |
| Genre | : Science |
| ISBN | : 3662437872 |
Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.
| Author | : Rajib Deb |
| Publisher | : Frontiers Media SA |
| Total Pages | : 104 |
| Release | : 2022-12-06 |
| Genre | : Medical |
| ISBN | : 2832508898 |
| Author | : Satyendra Chandra Tripathi |
| Publisher | : Frontiers Media SA |
| Total Pages | : 336 |
| Release | : 2021-03-01 |
| Genre | : Science |
| ISBN | : 2889665232 |
| Author | : Jens Kurreck |
| Publisher | : Royal Society of Chemistry |
| Total Pages | : 362 |
| Release | : 2008 |
| Genre | : Medical |
| ISBN | : 0854041168 |
This book provides a compelling overall update on current status of RNA interference
| Author | : Richard O'Kennedy |
| Publisher | : Wiley |
| Total Pages | : 0 |
| Release | : 1997-04-21 |
| Genre | : Science |
| ISBN | : 9780471969976 |
Coumarins: Biology, Applications and Mode of Action predominantly focuses on the parent compound, coumarin, and its main metabolite in humans, 7-hydroxycoumarin. It describes in detail every facet of these compounds including history, toxicology, chemistry, metabolism, analysis, clinical, veterinary and other applications, their roles as immunomodulatory agents and speculates on their mode of action.
| Author | : Eva Böttcher-Friebertshäuser |
| Publisher | : Springer |
| Total Pages | : 337 |
| Release | : 2018-05-22 |
| Genre | : Medical |
| ISBN | : 3319754742 |
This book will give an overview on viruses undergoing proteolytic activation through host proteases. The chapters will be organized in three themed parts, the first part describing respective viruses and their characteristics in detail. In the second part the molecular and cellular biology of the proteases involved as well as their physiological functions will be further explored. The third part will contain a chapter on protease inhibitors that are promising tools for antiviral therapy. This book will engage scholars in virology and medical microbiology as well as researchers with an interest in enzymology and protein structure and function relationship.
| Author | : Barry J. Maron |
| Publisher | : John Wiley & Sons |
| Total Pages | : 527 |
| Release | : 2008-04-15 |
| Genre | : Medical |
| ISBN | : 140514615X |
Diagnosis and Management of Hypertrophic Cardiomyopathy is aunique, multi-authored compendium of information regarding thecomplexities of clinical and genetic diagnosis, natural history,and management of hypertrophic cardiomyopathy (HCM)—the mostcommon and important of the genetic cardiovasculardiseases—as well as related issues impacting the health oftrained athletes. Edited by Dr. Barry J. Maron, a world authority on HCM, and withmajor contributions from all of the international experts in thisfield, this book provides a single comprehensive source ofinformation concerning HCM. Recent advances in the field arediscussed, including the importance of left ventricular outflowtract obstruction, the use of implantable defibrillators for theprevention of sudden death in young people, definition of thegenetic basis for HCM and its role in clinical diagnosis and riskstratification, the development of more precise strategies forassessing the level of risk for sudden death among all patientswith HCM, and the evolution of invasive interventions for heartfailure symptoms, such as surgical management and its alternatives(alcohol septal ablation and dual-chamber pacing). Key Features: Contributions from all experts in the field,representing diverse viewpoints regarding this heterogeneousdisease and related issues in athletes Information to dispel misunderstandings regarding issuesassociated with HCM and cardiovascular disease in athletes The only comprehensive source of information available on thetopic
| Author | : Silvia Melgar |
| Publisher | : Frontiers Media SA |
| Total Pages | : 250 |
| Release | : 2024-04-30 |
| Genre | : Medical |
| ISBN | : 2832548598 |
An interplay between the diet and the microbiota appears to regulate the host responses. It is now well acknowledged that the microbiota and their metabolites such as short chain fatty acids, bile acids, etc modulates the metabolic status, educates the host’s intestinal immune system, and protects the host against invading pathogens and injury. Concomitantly, environmental factors such as diets and dietary components play a major role in shaping the microbiota, thereby modulating the host immune and epithelial responses, and ultimately directing the individual’s health status. Disruption in any of these elements or their interactions have been linked to the development and progression of a wide range of conditions including Inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), colorectal cancer, obesity, Parkinson’s disease, autism, asthma etc. While westernised diets (rich in fat/sugar and low in fibres) and dietary additives (e.g. emulsifiers) have been identified as risk factors for these disorders, other diets such as Mediterranean, Ketogenic and probiotics and prebiotics can serve as treatment strategies due to their impact on the microbiota and possibly the host.
| Author | : A.G. de Boer |
| Publisher | : CRC Press |
| Total Pages | : 240 |
| Release | : 1997-04-08 |
| Genre | : Medical |
| ISBN | : 9789057020322 |
The availability of various in vitro and in vivo techniques has considerably advanced the research on drug transport and metabolism across the blood-brain barrier (BBB). These specialized and sophisticated experimental strategies are of fundamental importance if one is to gain a greater understanding of enhanced and selective drug delivery to the brain. The reader will find in this book methods for in vitro endothelial/astrocyte cell culture models, and for in vivo intracerebral microdialysis to study drug tranport across the BBB. This book, however, is not merely a laboratory manual consisting of recipes for BBB research; it permits the presentation of the different methods in fine detail, revealing tricks and short cuts that frequently do not appear in the literature. The researcher is well aware that differences (subtle or otherwise) in experimental steps used in different laboratories may influence the outcome of any particular procedure. The book also illustrates the accessibility and the application of the different methods in different species. Background information of the protocol is given in every chapter, which also contains a literature list that the reader may wish to refer to for further information. This volume will be invaluable to basic researchers as well as to those involved in the search for agents suitable for pharmaceutic intervention in the central nervous system.
