Excerpt from Archives of Neurology and Psychiatry, Vol. 6 In the following article we desire to summarize the development of our knowledge of sensory phenomena associated with pernicious anemia and to record the sensory changes encountered in forty-one cases of pernicious anemia studied in the Elliott Memorial Hospital of the University of Minnesota and in the university service of the Minneapolis General Hospital. Nearly all these cases were also studied by the members of Dr. Rowntree's staff in internal medicine and no case appears in our list in which the diagnosis of pernicious anemia was disputed. Most of our cases belong to the Addison-Biermer type of pernicious anemia. Historical Survey Addison (1855), in his original description of pernicious anemia, said nothing of involvement of the nervous system except that he found some fatty degeneration of a portion of the semilunar ganglion of the solar plexus. Biermer (1872) referred to: weakness, giddiness and palpitation and also reported capillary hemorrhages in the brain and the retina. In 1880, Herbert W. Little stated: "The indications of the nervous affection in this disease are: frequent cephalalgia, vertigo, syncope, neuralgic pains, dyspepsia, vomiting, diarrhea, mental depression, muscular weakness, pallor of the skin, reduction or rise of temperature." The author thought the nervous system the primary seat of trouble and involvement of the vasomotor system important. About the Publisher Forgotten Books publishes hundreds of thousands of rare and classic books. Find more at www.forgottenbooks.com This book is a reproduction of an important historical work. Forgotten Books uses state-of-the-art technology to digitally reconstruct the work, preserving the original format whilst repairing imperfections present in the aged copy. In rare cases, an imperfection in the original, such as a blemish or missing page, may be replicated in our edition. We do, however, repair the vast majority of imperfections successfully; any imperfections that remain are intentionally left to preserve the state of such historical works.