Aptamers In Biotechnology
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| Author | : Gulab Singh Yadav |
| Publisher | : Springer Nature |
| Total Pages | : 200 |
| Release | : 2019-11-11 |
| Genre | : Science |
| ISBN | : 9811388369 |
The book discusses the basics of aptamers and the advent of aptamer-based technology in recent times. The book covers the diverse applications of aptamers, such as in detection of animal and plant pathogens, disease diagnosis and therapeutics, environmental contamination detection etc. Besides these applications, the book also describes the use of these synthetic or modified DNA, as drug delivery vehicles. The different chapters describe how the binding capacity and specificity of aptamers can be exploited in various ways. The book also discusses how these attributes of aptamers can outdo the antibody technology in biomedical and diagnostic solutions. This crisp and concise book gives the readers an insight into the most recent biotechnological applications of aptamers.
| Author | : Katharina Urmann |
| Publisher | : Springer Nature |
| Total Pages | : 217 |
| Release | : 2020-07-31 |
| Genre | : Science |
| ISBN | : 3030540618 |
This book reviews the development, characterization and applications of aptamers in different areas of biotechnology ranging from therapeutics to diagnostics and protein purification. Hailed as chemical antibodies, these single-stranded nucleic acid receptors were predicted to supersede antibodies in traditional assays, such as ELISA, within a short time. While this has yet to happen, readers will find in this book a deep insight into the progress of aptamer technology and a critical discussion about the limitations that need to be overcome in order to find wider acceptance and use outside of the still relatively small aptamer-community. This book covers all aspects of aptamer generation and application for the aptamer-experienced reader and curious novice alike, with the addition of an industry perspective on the future of aptamer-use in biotechnology.
| Author | : Sven Klussmann |
| Publisher | : John Wiley & Sons |
| Total Pages | : 518 |
| Release | : 2006-08-21 |
| Genre | : Science |
| ISBN | : 3527607919 |
In The Aptamer Handbook, leading scientists from academia as well as biotech and pharma companies introduce the revolutionary concept of designing RNA and DNA oligonucleotides with novel functions by in vitro selection. These functions comprise high affinity binding (aptamers), catalytic activity (ribozymes and deoxyribozymes) or combinations of binding and catalytic properties (aptazymes). Basic concepts and technologies describing in detail how these functional oligonucleotides can be identified are presented. Numerous examples demonstrate the versatility of in vitro selected oligonucleotides. Special emphasis has been put on a section that shows the broad applicability of aptamers, e. g. in target validation, for analytics, or as new therapeutics. This first overview in the field is of prime interest for a broad audience of scientists both in academia and in industry who wish to expand their knowledge on the potential of new oligonucleotide functions and their applications.
| Author | : Yiyang Dong |
| Publisher | : Springer Nature |
| Total Pages | : 470 |
| Release | : 2021-03-25 |
| Genre | : Science |
| ISBN | : 9813348380 |
This book outlines comprehensively the main medical uses of aptamers, from diagnosis to therapeutics in fourteen chapters. Pioneering topics covered include aptamer pharmaceuticals, aptamers for malign tumors, aptamers for personalized therapeutics and aptamers for point-of-care testing. The book offers an essential guide for medical scientists interested in developing aptamer-based schemes for better theranostics. It is therefore of interest for not only academic researchers, but also practitioners and medical researchers in various fields of medical science, medical research and bio-analytical chemistry.
| Author | : Yiyang Dong |
| Publisher | : John Wiley & Sons |
| Total Pages | : 426 |
| Release | : 2019-02-11 |
| Genre | : Science |
| ISBN | : 3527342672 |
An essential guide that puts the focus on method developments and applications in aptamers In recent years, aptamer-based systems have been developed for a wide-range of analytical and medical applications. Aptamers for Analytical Applications offers an introduction to the topic, outlines the common protocols for aptamer synthesis, as well as providing information on the different optimization strategies that can obtain higher affinities to target molecules. The contributors?noted experts on the topic?provide an in-depth review of the characterization of aptamer-target molecule interaction and immobilization strategies and discuss the developments of methods for all the relevant applications. The book outlines different schemes to efficiently immobilize aptamers on substrates as well as summarizing the characterization methods for aptamer-ligand complexes. In addition, aptamer-based colorimetric, enzyme-linked, fluorescent, electrochemical, lateral flow and non-labeling analytical methods are presented. The book also reflects state-of-the-art and emerging applications of aptamer-based methods. This important resource: -Provides a guide to aptamers which provide highly specific and sensitive molecular recognition, with affinities in the range of antibodies and are much cheaper to produce -Offers a discussion of the analytical method developments and improvements with established systems and beyond -Offers a comprehensive guide to all the relevant application areas -Presents an authoritative book from contributors who are noted experts in the field Written for analytical chemists, biochemists, analytical researchers, Aptamers for Analytical Applications is a comprehensive book that adopts a methodological point of view to the important aspects of aptamer generation and modification with a strong emphasis on method developments for relevant applications.
| Author | : Matilde Otero-Losada |
| Publisher | : BoD – Books on Demand |
| Total Pages | : 350 |
| Release | : 2020-11-26 |
| Genre | : Medical |
| ISBN | : 1838804390 |
Neurological disease affects nearly 25%–30% of the world’s population, exerting enormous financial strain on the healthcare system. Estimated current costs are around $800 annual billion, and this number is expected to increase exponentially as the global population ages. As such, new and alternative neuroprotective strategies are urgently needed. This book examines some of the most promising approaches in neuroprotection as well as discusses current goals and prospects. Organized into three sections, chapters cover such topics as the use of cannabinoids, medicinal plants, and essential oils in Alzheimer’s and Parkinson’s; protein misfolding and the neuroprotective potential of vitamin E in cerebral ischemia; and potential new neurological treatments and their mechanisms of action.
| Author | : Sudhir Agrawal |
| Publisher | : Royal Society of Chemistry |
| Total Pages | : 566 |
| Release | : 2019-02-08 |
| Genre | : Science |
| ISBN | : 1788017323 |
The sequencing of the human genome and subsequent elucidation of the molecular pathways that are important in the pathology of disease have provided unprecedented opportunities for the development of new therapeutics. Nucleic acid-based drugs have emerged in recent years to yield extremely promising candidates for drug therapy to a wide range of diseases. Advances in Nucleic Acid Therapeutics is a comprehensive review of the latest advances in the field, covering the background of the development of nucleic acids for therapeutic purposes to the array of drug development approaches currently being pursued using antisense, RNAi, aptamer, immune modulatory and other synthetic oligonucleotides. Nucleic acid therapeutics is a field that has been continually innovating to meet the challenges of drug discovery and development; bringing contributions together from leaders at the forefront of progress, this book depicts the many approaches currently being pursued in both academia and industry. A go-to volume for medicinal chemists, Advances in Nucleic Acid Therapeutics provides a broad overview of techniques of contemporary interest in drug discovery.
| Author | : Hengjian Tong |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 300 |
| Release | : 2010-10-06 |
| Genre | : Computers |
| ISBN | : 3642163874 |
CCIS 107 is the second volume of the proceedings of the Fifth International Symposium on Intelligence Computation and Applications (ISICA 2010)held in Wuhan, China, October 22–24, 2010. Thirty-one papers among 267 submissions were selected and included in CCIS 107. This volume features the most up-to-date research in evolutionary design, evolutionary optimization, hybrid evolutionary algorithms, intelligent systems, particle swarm optimization, and predictive modeling. CCIS 107 is dedicated to the memory of Lishan Kang. ISICA conferences were one of the ?rst series of international conferences on computational - telligence that combined elements of learning, adaptation, evolution and fuzzy logic to create programs as alternative solutions to arti?cial intelligence. The idea for ISICA came about after Lishan Kang organized an international s- posium on evolutionarycomputation at Wuhan University in 2000. After he was invited to be the Director of the School of Computer Science, China University of Geosciences, he wondered whether he could establish such discussion forums on computational intelligence at China University of Geosciences. With support from his university, the School of Computer Science organizedthe ?rst ISICA in 2005, in which some of the leading ?gures from the scienti?c computing world were invited, including H. -P. Schwefel, Germany, M. Schoenauer, France, D. J. Evans, UK, T. Higuchi, Japan, Z. Michalewicz, Australia, and X. Yao, UK. The Second ISICA was jointly held in 2007 with the 7th International C- ference on Evolvable Systems: From Biology to Hardware (ICES 2007).
| Author | : Mahendra Rai |
| Publisher | : John Wiley & Sons |
| Total Pages | : 416 |
| Release | : 2020-11-10 |
| Genre | : Science |
| ISBN | : 1119671795 |
Presents nanobiotechnology in drug delivery and disease management Featuring contributions from noted experts in the field, this book highlights recent advances in the nano-based drug delivery systems. It also covers the diagnosis and role of various nanomaterials in the management of infectious diseases and non-infectious disorders, such as cancers and other malignancies and their role in future medicine. Nanobiotechnology in Diagnosis, Drug Delivery and Treatment starts by introducing how nanotechnology has revolutionized drug delivery, diagnosis, and treatments of diseases. It then focuses on the role of various nanocomposites in diagnosis, drug delivery, and treatment of diseases like cancer, Alzheimer's disease, diabetes, and many others. Next, it discusses the application of a variety of nanomaterials in the diagnosis and management of gastrointestinal tract disorders. The book explains the concept of nanotheranostics in detail and its role in effective monitoring of drug response, targeted drug delivery, enhanced drug accumulation in the target tissues, sustained as well as triggered release of drugs, and reduction in adverse effects. Other chapters cover aptamer-incorporated nanoparticle systems; magnetic nanoparticles; theranostics and vaccines; toxicological concerns of nanomaterials used in nanomedicine; and more. Provides a concise overview of state-of-the-art nanomaterials and their application like drug delivery in infectious diseases and non-infectious disorders Highlights recent advances in the nano-based drug delivery systems and role of various nanomaterials Introduces nano-based sensors which detect various pathogens Covers the use of nanodevices in diagnostics and theranostics Nanobiotechnology in Diagnosis, Drug Delivery and Treatment is an ideal book for researchers and scientists working in various disciplines such as microbiology, biotechnology, nanotechnology, pharmaceutical biotechnology, pharmacology, pharmaceutics, and nanomedicine.
| Author | : Elisabeth Eppard |
| Publisher | : BoD – Books on Demand |
| Total Pages | : 156 |
| Release | : 2021-09-29 |
| Genre | : Medical |
| ISBN | : 1839627832 |
In recent years, due to advancing technology and diagnostic and therapeutic techniques, medicine and health care have become more patient-oriented. This concept of personalized medicine or theranostics can be traced back to the beginnings of nuclear medicine when radioisotopes were uncovered as diagnostic and therapeutic tools. Nowadays, the field of theranostics is in flux, as new techniques and materials allow a growing range of applications beneficial for patients. This book examines new developments in theranostics and provides a comprehensive overview of the state of the art in this exciting discipline.
