Applied Statistics for Network Biology

Applied Statistics for Network Biology
Author: Matthias Dehmer
Publisher: John Wiley & Sons
Total Pages: 441
Release: 2011-04-08
Genre: Medical
ISBN: 3527638083

The book introduces to the reader a number of cutting edge statistical methods which can e used for the analysis of genomic, proteomic and metabolomic data sets. In particular in the field of systems biology, researchers are trying to analyze as many data as possible in a given biological system (such as a cell or an organ). The appropriate statistical evaluation of these large scale data is critical for the correct interpretation and different experimental approaches require different approaches for the statistical analysis of these data. This book is written by biostatisticians and mathematicians but aimed as a valuable guide for the experimental researcher as well computational biologists who often lack an appropriate background in statistical analysis.

Fundamentals Of Network Biology

Fundamentals Of Network Biology
Author: Wenjun Zhang
Publisher: World Scientific
Total Pages: 568
Release: 2018-05-18
Genre: Medical
ISBN: 1786345102

As the first comprehensive title on network biology, this book covers a wide range of subjects including scientific fundamentals (graphs, networks, etc) of network biology, construction and analysis of biological networks, methods for identifying crucial nodes in biological networks, link prediction, flow analysis, network dynamics, evolution, simulation and control, ecological networks, social networks, molecular and cellular networks, network pharmacology and network toxicology, big data analytics, and more.Across 12 parts and 26 chapters, with Matlab codes provided for most models and algorithms, this self-contained title provides an in-depth and complete insight on network biology. It is a valuable read for high-level undergraduates and postgraduates in the areas of biology, ecology, environmental sciences, medical science, computational science, applied mathematics, and social science.

Analyzing Network Data in Biology and Medicine

Analyzing Network Data in Biology and Medicine
Author: Nataša Pržulj
Publisher: Cambridge University Press
Total Pages: 647
Release: 2019-03-28
Genre: Science
ISBN: 1108386245

The increased and widespread availability of large network data resources in recent years has resulted in a growing need for effective methods for their analysis. The challenge is to detect patterns that provide a better understanding of the data. However, this is not a straightforward task because of the size of the data sets and the computer power required for the analysis. The solution is to devise methods for approximately answering the questions posed, and these methods will vary depending on the data sets under scrutiny. This cutting-edge text introduces biological concepts and biotechnologies producing the data, graph and network theory, cluster analysis and machine learning, before discussing the thought processes and creativity involved in the analysis of large-scale biological and medical data sets, using a wide range of real-life examples. Bringing together leading experts, this text provides an ideal introduction to and insight into the interdisciplinary field of network data analysis in biomedicine.

Discriminative Pattern Discovery on Biological Networks

Discriminative Pattern Discovery on Biological Networks
Author: Fabio Fassetti
Publisher: Springer
Total Pages: 51
Release: 2017-09-01
Genre: Computers
ISBN: 3319634771

This work provides a review of biological networks as a model for analysis, presenting and discussing a number of illuminating analyses. Biological networks are an effective model for providing insights about biological mechanisms. Networks with different characteristics are employed for representing different scenarios. This powerful model allows analysts to perform many kinds of analyses which can be mined to provide interesting information about underlying biological behaviors. The text also covers techniques for discovering exceptional patterns, such as a pattern accounting for local similarities and also collaborative effects involving interactions between multiple actors (for example genes). Among these exceptional patterns, of particular interest are discriminative patterns, namely those which are able to discriminate between two input populations (for example healthy/unhealthy samples). In addition, the work includes a discussion on the most recent proposal on discovering discriminative patterns, in which there is a labeled network for each sample, resulting in a database of networks representing a sample set. This enables the analyst to achieve a much finer analysis than with traditional techniques, which are only able to consider an aggregated network of each population.

Networks of Networks in Biology

Networks of Networks in Biology
Author: Narsis A. Kiani
Publisher: Cambridge University Press
Total Pages: 215
Release: 2021-04
Genre: Computers
ISBN: 1108428878

Introduces network inspired approaches for the analysis and integration of large, heterogeneous data sets in the life sciences.

Computational Network Analysis with R

Computational Network Analysis with R
Author: Matthias Dehmer
Publisher: John Wiley & Sons
Total Pages: 368
Release: 2016-07-22
Genre: Medical
ISBN: 3527694404

This new title in the well-established "Quantitative Network Biology" series includes innovative and existing methods for analyzing network data in such areas as network biology and chemoinformatics. With its easy-to-follow introduction to the theoretical background and application-oriented chapters, the book demonstrates that R is a powerful language for statistically analyzing networks and for solving such large-scale phenomena as network sampling and bootstrapping. Written by editors and authors with an excellent track record in the field, this is the ultimate reference for R in Network Analysis.

Computational Network Theory

Computational Network Theory
Author: Matthias Dehmer
Publisher: John Wiley & Sons
Total Pages: 200
Release: 2015-04-28
Genre: Medical
ISBN: 3527691537

This comprehensive introduction to computational network theory as a branch of network theory builds on the understanding that such networks are a tool to derive or verify hypotheses by applying computational techniques to large scale network data. The highly experienced team of editors and high-profile authors from around the world present and explain a number of methods that are representative of computational network theory, derived from graph theory, as well as computational and statistical techniques. With its coherent structure and homogenous style, this reference is equally suitable for courses on computational networks.

Advances in Network Complexity

Advances in Network Complexity
Author: Matthias Dehmer
Publisher: John Wiley & Sons
Total Pages: 298
Release: 2013-06-21
Genre: Medical
ISBN: 3527670483

A well-balanced overview of mathematical approaches to complex systems ranging from applications in chemistry and ecology to basic research questions on network complexity. Matthias Dehmer, Abbe Mowshowitz, and Frank Emmert-Streib, well-known pioneers in the fi eld, have edited this volume with a view to balancing classical and modern approaches to ensure broad coverage of contemporary research problems. The book is a valuable addition to the literature and a must-have for anyone dealing with network compleaity and complexity issues.

Statistical Diagnostics for Cancer

Statistical Diagnostics for Cancer
Author: Matthias Dehmer
Publisher: John Wiley & Sons
Total Pages: 301
Release: 2012-11-28
Genre: Medical
ISBN: 3527665455

This ready reference discusses different methods for statistically analyzing and validating data created with high-throughput methods. As opposed to other titles, this book focusses on systems approaches, meaning that no single gene or protein forms the basis of the analysis but rather a more or less complex biological network. From a methodological point of view, the well balanced contributions describe a variety of modern supervised and unsupervised statistical methods applied to various large-scale datasets from genomics and genetics experiments. Furthermore, since the availability of sufficient computer power in recent years has shifted attention from parametric to nonparametric methods, the methods presented here make use of such computer-intensive approaches as Bootstrap, Markov Chain Monte Carlo or general resampling methods. Finally, due to the large amount of information available in public databases, a chapter on Bayesian methods is included, which also provides a systematic means to integrate this information. A welcome guide for mathematicians and the medical and basic research communities.

Probabilistic Graphical Models for Genetics, Genomics, and Postgenomics

Probabilistic Graphical Models for Genetics, Genomics, and Postgenomics
Author: Christine Sinoquet
Publisher: Oxford University Press, USA
Total Pages: 483
Release: 2014
Genre: Mathematics
ISBN: 0198709021

At the crossroads between statistics and machine learning, probabilistic graphical models (PGMs) provide a powerful formal framework to model complex data. An expanding volume of biological data of various types, the so-called 'omics', is in need of accurate and efficient methods for modelling and PGMs are expected to have a prominent role to play.