This is a manual on how to do applied psychophysiological research and why. It is timely and necessary. Timely because applied psychophysiology has come to the attention of providers and the public who would like to benefit from the applications. In medicine many current publications address translational research. Applied psychophysiology is translational research in the area of psychophysiology. It is necessary because the validity of many claims of benefits for technologies and procedures are limited to testimonials and poorly designed research. It is necessary because there are few resources to specifically guide a researcher who undertakes applied psychophysiology. The goals of applied psychophysiology such as producing a useful effect are much different than the goals of basic research which are focused on validating a theoretical model. Different tools are required to attain those goals. Dr. Sherman is a seasoned psychophysiologist with extensive publications in basic and applied research. He has been a leader in professional societies fostering applied psychophysiology and he has refined the teachability of this material through years of teaching students in a graduate program of applied psychophysiology. It begins immediately with cardinal rules for establishing credibility when you are preparing a clinical presentation or attending to a clinical presentation. The rest of the book details how to address those rules. An introduction orients the reader to the purpose, needed statistical software, definitions of applied psychophysiology, the rationale of the discipline and a discussion of the scientific method. The content is then presented in five sections covering: A) The need to know what you are doing—from inspiration through protocol development, research ethics and protocol approval process, B) Basic study structures such as research designs appropriate for office or clinical environments, C) Establishing credibility of data and psychophysiological publications, D) Statistics for evaluating and interpreting psychophysiological data, and E) Synthesizing these elements so that write-ups and presentations use appropriate research designs and statistics, provide an adequate basis to secure any needed grants and provide credible evidence to the professional community. Additional sections F through J provide helps in the form of a glossary, sample protocols that exemplify good and bad models, recommendations for further readings and references. This book would work well for graduate students in applied psychophysiology, as it takes one through a carefully laid out series of steps from the beginning of inspiration through completed investigation and publication. It is an important resource for anyone reading or producing applied psychophysiology research because most training in research methods do not clearly address applied research.