Anticancer Drugsao Deoxyribonucleic Acid Dna Interactions
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| Author | : Awad Momen |
| Publisher | : |
| Total Pages | : 0 |
| Release | : 2022 |
| Genre | : Science |
| ISBN | : |
The deoxyribonucleic acid (DNA) is the molecule of life that controls all the chemical changes that take place in cells. The interaction of drugs with DNA is among the most important aspects of biological studies in drug discovery and pharmaceutical development processes. Moreover, the knowledge of specific targets in rational design of chemotherapeutics is a fundamental factor, principally, for the design of molecules that can be used in the treatment of oncologic diseases. Observing the pre- and postsigns of drug-DNA interaction provides good evidence for the interaction mechanism to be elucidated. Also, this interaction could be used for the quantification of drugs and for the determination of new drugs targeting DNA. Approaches can provide new insight into rational drug design and would lead to further understanding of the interaction mechanism between anticancer drugs and DNA. The intention of this chapter is to provide several examples of anticancer drugs, DNA interaction, and the mechanisms of interaction in order to understand the influence of several interaction factors in the capacity and selectivity of the anticancer drugs to interact with DNA. In addition, different experimental and theoretical approaches to detect and to evaluate the anticancer drugs,Äô interactions with DNA were also discussed.
| Author | : Stephen Neidle |
| Publisher | : CRC Press |
| Total Pages | : 386 |
| Release | : 1994-05-03 |
| Genre | : Medical |
| ISBN | : 9780849377730 |
This cutting-edge book surveys the current knowledge on the mode of action of the major classes of DNA-interactive antitumor agents, providing information that could be crucial for the discovery of new therapeutic substances. It is an important reference for molecular biologists, cancer researchers, biochemists, biophysicists, and pharmacologists.
| Author | : Neidle |
| Publisher | : CRC Press |
| Total Pages | : 394 |
| Release | : 1993-08-16 |
| Genre | : Medical |
| ISBN | : 9780849377709 |
This cutting-edge book surveys the current knowledge on the mode of action of the major classes of DNA-interactive antitumor agents, providing information that could be crucial for the discovery of new therapeutic substances. It is an important reference for molecular biologists, cancer researchers, biochemists, biophysicists, and pharmacologists.
| Author | : Stephen Neidle |
| Publisher | : |
| Total Pages | : 0 |
| Release | : 1993 |
| Genre | : Antimitotic agents |
| ISBN | : 9780333551158 |
| Author | : Chandanamalie Punchihewa |
| Publisher | : |
| Total Pages | : 280 |
| Release | : 2006 |
| Genre | : |
| ISBN | : 9780415380874 |
DNA is both the oldest and newest of targets for cancer therapy. While it is already being targeted by many anticancer drugs in the clinic, the development of sequence-specific DNA binders has brought it back to the limelight as a valuable anticancer drug target.
| Author | : Diane Marsh Riebeth |
| Publisher | : |
| Total Pages | : 340 |
| Release | : 1987 |
| Genre | : Antimitotic agents |
| ISBN | : |
| Author | : Stephen Neidle (ed) |
| Publisher | : |
| Total Pages | : |
| Release | : 1993 |
| Genre | : |
| ISBN | : |
| Author | : Bruce C. Baguley |
| Publisher | : Elsevier |
| Total Pages | : 411 |
| Release | : 2001-11-17 |
| Genre | : Medical |
| ISBN | : 0080490441 |
Here in a single source is a complete spectrum of ideas on the development of new anticancer drugs. Containing concise reviews of multidisciplinary fields of research, this book offers a wealth of ideas on current and future molecular targets for drug design, including signal transduction, the cell division cycle, and programmed cell death. Detailed descriptions of sources for new drugs and methods for testing and clinical trial design are also provided. One work that can be consulted for all aspects of anticancer drug development Concise reviews of research fields, combined with practical scientific detail, written by internationally respected experts A wealth of ideas on current and future molecular targets for drug design, including signal transduction, the cell division cycle, and programmed cell death Detailed descriptions of the sources of new anticancer drugs, including combinatorial chemistry, phage display, and natural products Discussion of how new drugs can be tested in preclinical systems, including the latest technology of robotic assay systems, cell culture, and experimental animal techniques Hundreds of references that allow the reader to access relevant scientific and medical literature Clear illustrations, some in color, that provide both understanding of the field and material for teaching
| Author | : Michael Waring |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 300 |
| Release | : 1992-11-30 |
| Genre | : Medical |
| ISBN | : 9780792389590 |
Most of the anti-cancer drugs in use today were discovered by happy accident rather than design, yet the rational design of better anti-cancer drugs remains a cherished goal, and one of the most important challenges facing medical science. This book represents a compilation of views and progress reports which illustrate the diversity of approaches to the problem. Recent research has confirmed the belief that critical genetic changes are at work in cancer cells. The genome, then (DNA in biochemical terms), surely represents a critical target for specific chemotherapy of cancer, and several chapters address the issue of attacking DNA, gene targetting, and the like. Others deal with principles of rational design, exploitation of novel modalities and targets, or the nuts and bolts of antitumour drug testing. While no attempt has been made to provide a comprehensive coverage of this wide-ranging and vitally important subject, the present volume in the series will provide much food for thought.
| Author | : Toshiwo Andoh |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 208 |
| Release | : 2012-12-06 |
| Genre | : Science |
| ISBN | : 1461501415 |
In the mid 80's type I and II enzymes were found to be the intracellular targets of a number of efficacious anticancer drugs such as doxorubicin, mitoxantrone, etoposide and camptothecin as a result of a continued efforts of many investigators, especially Leroy Liu and his collaborators at Johns Hopkins University. Readers will find a series of chapters written by researchers actively engaged in the expanding field of topoisomerase and their inhibitors. The series of chapters cover review articles on pharmacology and the molecular mechanism of topoisomerase I- and II-targeting anticancer drugs in mammals and in the yeast Saccharomyces cerevisiae, which has proved to be a superb model organism for studies of anticancer drugs. This volume compiles up-to-date information on the topoisomerase-targeting compounds in clinical and preclinical development as a useful and important reference book for students and researchers in the field of pharmacology, toxicology, oncology and molecular biology.
