Antibody Fusion Proteins For The Treatment Of Rheumatoid Arthritis And Cancer
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Safety of Biologics Therapy
| Author | : Brian A. Baldo |
| Publisher | : Springer |
| Total Pages | : 623 |
| Release | : 2016-08-12 |
| Genre | : Medical |
| ISBN | : 3319304720 |
This long overdue title provides a comprehensive, up-to-date, state-of-the art review of approved biologic therapies, with coverage of mechanisms of action, Indications for therapy, immunogenicity and a detailed examination of adverse effects and safety of the many and diverse therapeutic agents presented in a total of 13 chapters. It is predicted that by 2016, biologics will make up half of the world's 20 top-selling drugs and by 2018, biologic medicine sales will account for almost half of the world's 100 biggest selling drugs. Recombinant proteins dominate the growing list of the more than 200 approved biotherapeutic agents with targeted antibodies, fusion proteins and receptors; cytokines; hormones; enzymes; proteins involved in blood-clotting, homeostasis and thrombosis; vaccines; botulinum neurotoxins; and, more recently, biosimilar preparations, comprising the majority of approved biologics. Written with clinicians, other health care professionals, and researchers in mind, Safety of Biologics Therapy examines, in a single volume, the full range of issues surrounding the safety of approved biologic therapies. A good understanding of the risks and safety issues of modern biologics therapy is increasingly being demanded of all those connected with their development, handling, prescribing, administration and subsequent patient management. In addition to being of great value to clinicians in all branches of medicine, and to nurses, pharmacists and researchers, this book will prove invaluable for students taking undergraduate and graduate courses in the above disciplines and in the biomedical sciences.
Therapeutic Antibodies
| Author | : Yuti Chernajovsky |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 381 |
| Release | : 2007-12-11 |
| Genre | : Medical |
| ISBN | : 3540732594 |
This essential work, edited by two researchers at London’s famous Queen Mary’s medical school targets one of the most important areas in medical development today. These days, antibody therapeutics are the treatment of choice for several autoimmune and oncological conditions. They are, indeed, becoming the molecules of choice for further combination therapies and cell engineering. In this timely work, a slew of expert in the field of drug development summarize all the current developments and clinical successes.
Antibody-Cytokine Fusion Proteins for the Therapy of Breast Cancer
| Author | : |
| Publisher | : |
| Total Pages | : 133 |
| Release | : 2002 |
| Genre | : |
| ISBN | : |
In this grant we proposed to explore the use of genetically engineered antibodies as therapeutic agents specifically attempting to augment and potentiate the host immune defense systems against breast cancer. The antibodies were to be specific for HER2/neu, a molecule present on the surface of many breast cancers; its increased expression is associated with poor prognosis. To these antibodies we proposed to join the cytokines IL-2, IL-12, and GM-CSF. Expression of these cytokines by cancer cells has been shown to render them immunogenic. The anti- HER2/neu antibody fusion proteins were intended to localize the cytokine at the tumor where it is expected to elicit an immune response. To accomplish our goals we proposed three specific aims. Specific Aim 1: To produce rL-2, IL-12, GM-CSF antibody fusion proteins specific for HER2/neu. Specific Aim 2: To evaluate the properties of the antibody fusion proteins in vitro. Specific Aim 3: To determine the properties of the antibody fusion proteins in vivo and their effectiveness in causing anti-tumor response. These there specific aims have been accomplished by the end of the third year of the present award.
Frontiers of Engineering
| Author | : National Academy of Engineering |
| Publisher | : National Academies Press |
| Total Pages | : 145 |
| Release | : 2017-01-30 |
| Genre | : Technology & Engineering |
| ISBN | : 030945039X |
This volume presents papers on the topics covered at the National Academy of Engineering's 2016 US Frontiers of Engineering Symposium. Every year the symposium brings together 100 outstanding young leaders in engineering to share their cutting-edge research and innovations in selected areas. The 2016 symposium was held September 19-21 at the Arnold and Mabel Beckman Center in Irvine, California. The intent of this book is to convey the excitement of this unique meeting and to highlight innovative developments in engineering research and technical work.
Drug-Induced Liver Injury
| Author | : |
| Publisher | : Academic Press |
| Total Pages | : 288 |
| Release | : 2019-07-13 |
| Genre | : Medical |
| ISBN | : 0128173173 |
Drug-Induced Liver Injury, Volume 85, the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this new release include Cell death mechanisms in DILI, Mitochondria in DILI, Primary hepatocytes and their cultures for the testing of drug-induced liver injury, MetaHeps an alternate approach to identify IDILI, Autophagy and DILI, Biomarkers and DILI, Regeneration and DILI, Drug-induced liver injury in obesity and nonalcoholic fatty liver disease, Mechanisms of Idiosyncratic Drug-Induced Liver Injury, the Evaluation and Treatment of Acetaminophen Toxicity, and much more. Includes the authority and expertise of leading contributors in pharmacology Presents the latest release in the Advances in Pharmacology series
Resistance to Anti-CD20 Antibodies and Approaches for Their Reversal
| Author | : |
| Publisher | : Elsevier |
| Total Pages | : 444 |
| Release | : 2023-08-30 |
| Genre | : Computers |
| ISBN | : 0443192014 |
Resistance to Anti-CD20 Antibodies and Approaches for Their Reversal presents in-depth content written by international experts in the study of resistance to anti-CD20 antibodies and approaches for their reversal. Anti-CD20 antibodies are used to achieve B cell depletion and are developed to treat B cell proliferative disorders, including non-Hodgkin’s lymphoma and chronic lymphocytic leukemia. In the past two decades, anti-CD20 antibodies have revolutionized the treatment of all B cell malignancies, however, there are patients that fail to respond to initial therapy or relapse sooner. This book explores new and existing avenues surrounding Anti-CD20 antibodies. In recent years, several next-generation anti-CD20 therapies have been developed but predicting and reversing resistance is still a challenging task. These areas are being actively studied as they represent a potential to improve anti-CD20 therapies and are discussed thoroughly in the book. It is a valuable resource for researchers, students and member of the biomedical and medical fields who want to learn more about resistance to anti-CD20 antibodies and their reversal. • Presentation of current research, critical analyses, in-depth literature reviews, and the latest clinical reports on anti-CD20 antibody treatment • Discussion of recent developments of anti-CD20 antibodies in cancer and noncancer diseases treatment, possible resistance mechanisms and their reversals, as well as the exciting therapeutic opportunities offered by anti-CD20 antibodies in combination with chemotherapy or other treatment modalities • Utilization of a number of diagrams to visually illustrate complex content and plenty of tables to summarize important information
New Antibody Formats
| Author | : |
| Publisher | : Academic Press |
| Total Pages | : 214 |
| Release | : 2022-06-29 |
| Genre | : Science |
| ISBN | : 0323994105 |
New Antibody Formats, Volume 369 in the International Review of Cell and Molecular Biology serial, highlights new advances in the field with this new volume presenting interesting chapters on a variety of important topics, including Current innovative engineered antibodies, Advances in bispecific antibodies, Applications of trimerbodies for cancer immunotherapy, Multispecific mAb-Anticalin formats, New antibody formats to treat Lung Cancer, Immunocytokines: from bench to bedside, and Single domain antibodies in cancer. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the International Review of Cell and Molecular Biology serials Updated release includes the latest information on New Antibody Formats
Proteins
| Author | : Gary Walsh |
| Publisher | : John Wiley & Sons |
| Total Pages | : 447 |
| Release | : 2014-03-13 |
| Genre | : Science |
| ISBN | : 1118851471 |
Proteins Biochemistry and Biotechnology 2e is a definitive source of information for all those interested in protein science, and particularly the commercial production and isolation of specific proteins, and their subsequent utilization for applied purposes in industry and medicine. Fully updated throughout with new or fundamentally revised sections on proteomics as, bioinformatics, protein glycosylation and engineering, well as sections detailing advances in upstream processing and newer protein applications such as enzyme-based biofuel production this new edition has an increased focus on biochemistry to ensure the balance between biochemisty and biotechnology, enhanced with numerous case studies. This second edition is an invaluable text for undergraduates of biochemistry and biotechnology but will also be relevant to students of microbiology, molecular biology, bioinformatics and any branch of the biomedical sciences who require a broad overview of the various medical, diagnostic and industrial uses of proteins. • Provides a comprehensive overview of all aspects of protein biochemisty and protein biotechnology • Includes numerous case studies • Increased focus on protein biochemistry to ensure balance between biochemisty and biotechnology • Includes new section focusing on proteomics as well as sections detailing protein function and enzyme-based biofuel production "With the potential of a standard reference source on the topic, any molecular biotechnologist will profit greatly from having this excellent book. " (Engineering in Life Sciences, 2004; Vol 5; No. 5) “Few texts would be considered competitors, and none compare favorably." (Biochemistry and Molecular Education, July/August 2002) "...The book is well written, making it informative and easy to read..." (The Biochemist, June 2002)
