Mechanisms of antibiotic resistance

Mechanisms of antibiotic resistance
Author: Jun Lin
Publisher: Frontiers Media SA
Total Pages: 226
Release: 2015-06-01
Genre: Antibiotics
ISBN: 2889195260

Antibiotics represent one of the most successful forms of therapy in medicine. But the efficiency of antibiotics is compromised by the growing number of antibiotic-resistant pathogens. Antibiotic resistance, which is implicated in elevated morbidity and mortality rates as well as in the increased treatment costs, is considered to be one of the major global public health threats (www.who.int/drugresistance/en/) and the magnitude of the problem recently prompted a number of international and national bodies to take actions to protect the public (http://ec.europa.eu/dgs/health_consumer/docs/road-map-amr_en.pdf: http://www.who.int/drugresistance/amr_global_action_plan/en/; http://www.whitehouse.gov/sites/default/files/docs/carb_national_strategy.pdf). Understanding the mechanisms by which bacteria successfully defend themselves against the antibiotic assault represent the main theme of this eBook published as a Research Topic in Frontiers in Microbiology, section of Antimicrobials, Resistance, and Chemotherapy. The articles in the eBook update the reader on various aspects and mechanisms of antibiotic resistance. A better understanding of these mechanisms should facilitate the development of means to potentiate the efficacy and increase the lifespan of antibiotics while minimizing the emergence of antibiotic resistance among pathogens.

Disease Control Priorities, Third Edition (Volume 6)

Disease Control Priorities, Third Edition (Volume 6)
Author: King K. Holmes
Publisher: World Bank Publications
Total Pages: 1027
Release: 2017-11-06
Genre: Medical
ISBN: 1464805253

Infectious diseases are the leading cause of death globally, particularly among children and young adults. The spread of new pathogens and the threat of antimicrobial resistance pose particular challenges in combating these diseases. Major Infectious Diseases identifies feasible, cost-effective packages of interventions and strategies across delivery platforms to prevent and treat HIV/AIDS, other sexually transmitted infections, tuberculosis, malaria, adult febrile illness, viral hepatitis, and neglected tropical diseases. The volume emphasizes the need to effectively address emerging antimicrobial resistance, strengthen health systems, and increase access to care. The attainable goals are to reduce incidence, develop innovative approaches, and optimize existing tools in resource-constrained settings.

Antimicrobial Resistance in Developing Countries

Antimicrobial Resistance in Developing Countries
Author: Aníbal de J. Sosa
Publisher: Springer Science & Business Media
Total Pages: 553
Release: 2009-10-08
Genre: Science
ISBN: 0387893709

Avoiding infection has always been expensive. Some human populations escaped tropical infections by migrating into cold climates but then had to procure fuel, warm clothing, durable housing, and crops from a short growing season. Waterborne infections were averted by owning your own well or supporting a community reservoir. Everyone got vaccines in rich countries, while people in others got them later if at all. Antimicrobial agents seemed at first to be an exception. They did not need to be delivered through a cold chain and to everyone, as vaccines did. They had to be given only to infected patients and often then as relatively cheap injectables or pills off a shelf for only a few days to get astonishing cures. Antimicrobials not only were better than most other innovations but also reached more of the world’s people sooner. The problem appeared later. After each new antimicrobial became widely used, genes expressing resistance to it began to emerge and spread through bacterial populations. Patients infected with bacteria expressing such resistance genes then failed treatment and remained infected or died. Growing resistance to antimicrobial agents began to take away more and more of the cures that the agents had brought.

Infectious Disease Emergencies, An Issue of Emergency Medicine Clinics of North America, E-Book

Infectious Disease Emergencies, An Issue of Emergency Medicine Clinics of North America, E-Book
Author: Christopher M. Colbert
Publisher: Elsevier Health Sciences
Total Pages: 297
Release: 2024-04-22
Genre: Medical
ISBN: 0443130469

In this issue of Emergency Medicine Clinics, guest editors Drs. Christopher M. Colbert, Bradley W. Frazee, and Michael Pulia bring their considerable expertise to the topic of Infectious Disease Emergencies. Top experts in the field discuss key topics such as diabetic foot infections, tick-borne illness, STI diagnosis and management in the ED, bioterrorism, fever and rash, and more. - Contains 13 relevant, practice-oriented topics including updates on pneumonia; global medicine updates; COVID diagnosis and treatment; cutting-edge diagnostics and stewardship interventions; newly-approved antibiotics; and more. - Provides in-depth clinical reviews on infectious disease emergencies, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Pediatric Infections, An Issue of Infectious Disease Clinics of North America, E-Book

Pediatric Infections, An Issue of Infectious Disease Clinics of North America, E-Book
Author: Jason G. Newland
Publisher: Elsevier Health Sciences
Total Pages: 249
Release: 2022-02-24
Genre: Medical
ISBN: 0323835430

In this issue, guest editors bring their considerable expertise to this important topic.Provides in-depth reviews on the latest updates in the field, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews.

Sexually Transmitted Infections, An Issue of Infectious Disease Clinics of North America, E-Book

Sexually Transmitted Infections, An Issue of Infectious Disease Clinics of North America, E-Book
Author: Jeanne Marrazzo
Publisher: Elsevier Health Sciences
Total Pages: 249
Release: 2023-04-28
Genre: Medical
ISBN: 0443183031

In this issue of Infectious Disease Clinics of North America, guest editor Dr. Jeanne Marrazzo brings her considerable expertise to the topic of Sexually Transmitted Infections. The CDC approximates that 20% of Americans have experienced a sexually transmitted infection (STI), and the World Health Organization has estimated that over 340 million people live with STIs worldwide every year. In this issue, top experts provide important updates in this area, with goals to provide the relevant clinical information to aid physicians in prevention, diagnosis, and management. - Contains 14 practice-oriented topics including syphilis: a modern resurgence; update in management and prevention of chlamydial infections; non-herpes and non-syphilis causes of genital ulcer disease (including monkeypox, LGV, chancroid); diagnostic advances in sexually transmitted infections; immunizations for sexually transmitted infections; and more. - Provides in-depth clinical reviews on sexually transmitted infections, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Antimicrobial Resistance

Antimicrobial Resistance
Author: World Health Organization
Publisher:
Total Pages: 232
Release: 2014
Genre: Medical
ISBN: 9789241564748

Summary report published as technical document with reference number: WHO/HSE/PED/AIP/2014.2.

Antimicrobial Resistance

Antimicrobial Resistance
Author: Institute of Medicine
Publisher: National Academies Press
Total Pages: 128
Release: 1998-06-13
Genre: Science
ISBN: 0309060842

Antibiotic resistance is neither a surprising nor a new phenomenon. It is an increasingly worrisome situation, however, because resistance is growing and accelerating while the world's tools for combating it decrease in power and number. In addition, the cost of the problemâ€"especially of multidrug resistanceâ€"in terms of money, mortality, and disability are also rising. This book summarizes a workshop on antimicrobial resistance held by the Forum on Emerging Infections. The goal of the Forum on Emerging Infections is to provide an opportunity for representatives of academia, industry, government, and professional and interest groups to examine and discuss scientific and policy dilemmas of common interest that are specifically related to research on and the prevention, detection, and management of emerging infections. Organized as a topic-by-topic synthesis of presentations and exchanges during the workshop, the book highlights lessons learned, delineates a range of pivotal issues and the problems they raise, and proposes some simplified ideas about possible responses.

Transplant-Related Infections, An Issue of Infectious Disease Clinics of North America, E-Book

Transplant-Related Infections, An Issue of Infectious Disease Clinics of North America, E-Book
Author: Kimberly E. Hanson
Publisher: Elsevier Health Sciences
Total Pages: 249
Release: 2023-08-02
Genre: Medical
ISBN: 0443183791

In this issue, guest editors bring their considerable expertise to this important topic. - Contains 14 practice-oriented topics including COVID-19 prevention in organ transplant recipients; COVID-19 management in organ transplant recipients; updates in molecular diagnostics in organ transplant recipients; updates in immunizations for organ transplant recipients; data that inform "low hanging fruit antimicrobial stewardship interventions among solid organ transplant recipients; and more. - Provides in-depth clinical reviews of transplant-related infections, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

After the COVID-19 Crisis: Update on Complex Infectious Disease Issues in the Intensive Care Unit, An Issue of Infectious Disease Clinics of North America, E-Book

After the COVID-19 Crisis: Update on Complex Infectious Disease Issues in the Intensive Care Unit, An Issue of Infectious Disease Clinics of North America, E-Book
Author: Naomi P. O'Grady
Publisher: Elsevier Health Sciences
Total Pages: 209
Release: 2022-11-03
Genre: Medical
ISBN: 032396088X

In this issue of Infectious Disease Clinics of North America, guest editors Drs. Naomi P. O'Grady and Sameer Kadri bring their considerable expertise to the topic of Complex Infectious Diseases Issues in the Intensive Care Unit. Affected immunity of patients with COVID-19 has made management of complex infectious diseases in the intensive care unit more important than ever. This issue provides key updates for managing these complex infectious diseases and includes current clinical information for COVID-19 patients, making this a state-of-the-art collection of review articles for practicing infectious disease physicians. - Contains 13 practice-oriented topics including timing and spectrum of antibiotic treatment for suspected sepsis and septic shock; preparing an ICU for a lethal viral respiratory pandemic; rapid implementation of a system-level ICU pandemic surge staffing amidst quarantined staff and infection control barriers; management of serious SARS-CoV-2 infection with immunotherapies; supportive care in patients with critical COVID-19; and more. - Provides in-depth clinical reviews on complex infectious diseases issues in the ICU, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.