Neuroplasticity is the ability of neural networks in the brain to change through growth and reorganization. It is when the brain is rewired to function in some way that differs from how it previously functioned. How does aging affect neuroplasticity? As we grow older, plasticity decreases to stabilize what we have already learned. What influence does the aging process have on memory? Forgetfulness can be a normal part of aging. As people get older, changes occur in all parts of the body, including the brain. As a result, some people may notice that it takes longer to learn new things, they don't remember information as well as they did, or they lose things like their glasses. This book on evolving neuroscience is unique in its lifespan focus on driving neuroplasticity in a positive direction to influence the Flynn effect of increasing human intelligence as the preferred way to prevent, delay onset, and/or reverse dementia. It considers potential impact from the first moments of life through end of life. It includes intergenerational activities. Its inclusion of centenarians and supercentenarians provides examples of “Super Agers” who have maintained and/or increased neurocognitive capacity, often with a health span that approximated their vigorous longevity. It discusses the use of the Artificial Intelligence (AI) revolution to refine, personalize, and broaden our global reach to enhance the Flynn effect as the preferred effort to improve global statistics on neurocognitive functioning at any age. Driving neuroplasticity in a positive direction at all ages is urgent. With this book’s focus on evidence-based interventions at any age which can have physical, emotional, neurobiological, neurochemical, immunological, and social health benefits, it is a unique overview and application of evolving neuroscience to address the UN/WHO Decade of Action for Healthy Ageing for All.