Cancer Care for the Whole Patient

Cancer Care for the Whole Patient
Author: Institute of Medicine
Publisher: National Academies Press
Total Pages: 455
Release: 2008-03-19
Genre: Medical
ISBN: 0309134161

Cancer care today often provides state-of-the-science biomedical treatment, but fails to address the psychological and social (psychosocial) problems associated with the illness. This failure can compromise the effectiveness of health care and thereby adversely affect the health of cancer patients. Psychological and social problems created or exacerbated by cancer-including depression and other emotional problems; lack of information or skills needed to manage the illness; lack of transportation or other resources; and disruptions in work, school, and family life-cause additional suffering, weaken adherence to prescribed treatments, and threaten patients' return to health. Today, it is not possible to deliver high-quality cancer care without using existing approaches, tools, and resources to address patients' psychosocial health needs. All patients with cancer and their families should expect and receive cancer care that ensures the provision of appropriate psychosocial health services. Cancer Care for the Whole Patient recommends actions that oncology providers, health policy makers, educators, health insurers, health planners, researchers and research sponsors, and consumer advocates should undertake to ensure that this standard is met.

How Tobacco Smoke Causes Disease

How Tobacco Smoke Causes Disease
Author: United States. Public Health Service. Office of the Surgeon General
Publisher:
Total Pages: 728
Release: 2010
Genre: Government publications
ISBN:

This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.

The Drug Development Paradigm in Oncology

The Drug Development Paradigm in Oncology
Author: National Academies of Sciences, Engineering, and Medicine
Publisher: National Academies Press
Total Pages: 145
Release: 2018-02-12
Genre: Medical
ISBN: 0309457971

Advances in cancer research have led to an improved understanding of the molecular mechanisms underpinning the development of cancer and how the immune system responds to cancer. This influx of research has led to an increasing number and variety of therapies in the drug development pipeline, including targeted therapies and associated biomarker tests that can select which patients are most likely to respond, and immunotherapies that harness the body's immune system to destroy cancer cells. Compared with standard chemotherapies, these new cancer therapies may demonstrate evidence of benefit and clearer distinctions between efficacy and toxicity at an earlier stage of development. However, there is a concern that the traditional processes for cancer drug development, evaluation, and regulatory approval could impede or delay the use of these promising cancer treatments in clinical practice. This has led to a number of effortsâ€"by patient advocates, the pharmaceutical industry, and the Food and Drug Administration (FDA)â€"to accelerate the review of promising new cancer therapies, especially for cancers that currently lack effective treatments. However, generating the necessary data to confirm safety and efficacy during expedited drug development programs can present a unique set of challenges and opportunities. To explore this new landscape in cancer drug development, the National Academies of Sciences, Engineering, and Medicine developed a workshop held in December 2016. This workshop convened cancer researchers, patient advocates, and representatives from industry, academia, and government to discuss challenges with traditional approaches to drug development, opportunities to improve the efficiency of drug development, and strategies to enhance the information available about a cancer therapy throughout its life cycle in order to improve its use in clinical practice. This publication summarizes the presentations and discussions from the workshop.

Proceedings of the Conference on Promoting Undergraduate Research in Mathematics

Proceedings of the Conference on Promoting Undergraduate Research in Mathematics
Author: Joseph A. Gallian
Publisher:
Total Pages: 455
Release: 2007
Genre: Mathematics
ISBN: 9780821843215

Descriptions of summer research programs: The AIM REU: Individual projects with a common theme by D. W. Farmer The Applied Mathematical Sciences Summer Institute by E. T. Camacho and S. A. Wirkus Promoting research and minority participantion via undergraduate research in the mathematical sciences. MTBI/SUMS-Arizona State University by C. Castillo-Chavez, C. Castillo-Garsow, G. Chowell, D. Murillo, and M. Pshaenich Summer mathematics research experience for undergraduates (REU) at Brigham Young University by M. Dorff Introducing undergraduates for underrepresented minorities to mathematical research: The CSU Channel Islands/California Lutheran University REU, 2004-2006 by C. Wyels The REUT and NREUP programs at California State University, Chico by C. M. Gallagher and T. W. Mattman Undergraduate research at Canisius. Geometry and physics on graphs, summer 2006 by S. Prassidis The NSF REU at Central Michigan University by S. Narayan and K. Smith Claremont Colleges REU, 2005-07 by J. Hoste The first summer undergraduate research program at Clayton State University by A. Lanz Clemson REU in computational number theory and combinatorics by N. Calkin and K. James Research with pre-mathematicians by C. R. Johnson Traditional roots, new beginnings: Transitions in undergraduate research in mathematics at ETSU by A. P. Godbole Undergraduate research in mathematics at Grand Valley State University by S. Schlicker The Hope College REU program by T. Pennings The REU experience at Iowa State University by L. Hogben Lafayette College's REU by G. Gordon LSU REU: Graphs, knots, & Dessins in topology, number theory & geometry by N. W. Stoltzfus, R. V. Perlis, and J. W. Hoffman Mount Holyoke College mathematics summer research institute by M. M. Robinson The director's summer program at the NSA by T. White REU in mathematical biology at Penn State Erie, The Behrend College by J. P. Previte, M. A. Rutter, and S. A. Stevens The Rice University Summer Institute of Statistics (RUSIS) by J. Rojo The Rose-Hulman REU in mathematics by K. Bryan The REU program at DIMACS/Rutgers University by B. J. Latka and F. S. Roberts The SUNY Potsdam-Clarkson University REU program by J. Foisy The Trinity University research experiences for undergraduates in mathematics program by S. Chapman Undergraduate research in mathematics at the University of Akron by J. D. Adler The Duluth undergraduate research program 1977-2006 by J. A. Gallian Promoting undergraduate research in mathematics at the University of Nebraska-Lincoln by J. L. Walker, W. Ledder, R. Rebarber, and G. Woodward REU site: Algorithmic combinatorics on words by F. Blanchet-Sadri Promoting undergraduate research by T. Aktosun Research experiences for undergraduates inverse problems for electrical networks by J. A. Morrow Valparaiso experiences in research for undergraduates in mathematics by R. Gillman and Z. Szaniszlo Wabash Summer Institute in Algebra (WSIA) by M. Axtell, J. D. Phillips, and W. Turner THe SMALL program at Williams College by C. E. Silva and F. Morgan Industrial mathematics and statistics research for undergraduates at WPI by A. C. Heinricher and S. L. Weekes Descriptions of summer enrichment programs: Twelve years of summer program for women in mathematics-What works and why? by M. M. Gupta Research experience for undergraduates in numerical analysis and scientific computing: An international program by G. Fairweather and B. M. Moskal Articles: The Long-Term Undergraduate Research (LURE) model by S. S. Adams, J. A. Davis, N. Eugene, K. Hoke, S. Narayan, and K. Smith Research with students from underrepresented groups by R. Ashley, A. Ayela-Uwangue, F. Cabrera, C. Callesano, and D. A. Narayan Research classes at Gettysburg College by B. Bajnok Research in industrial projects for students: A unique undergraduate experience by S. Beggs What students say about their REU experience by F. Connolly and J. A. Gallian Diversity issues in undergraduate research by R. Cortez, D. Davenport, H

Advancing the Science of Cancer in Latinos

Advancing the Science of Cancer in Latinos
Author: Amelie G. Ramirez
Publisher: Springer Nature
Total Pages: 320
Release: 2019-11-21
Genre: Medical
ISBN: 303029286X

This open access book gives an overview of the sessions, panel discussions, and outcomes of the Advancing the Science of Cancer in Latinos conference, held in February 2018 in San Antonio, Texas, USA, and hosted by the Mays Cancer Center and the Institute for Health Promotion Research at UT Health San Antonio. Latinos – the largest, youngest, and fastest-growing minority group in the United States – are expected to face a 142% rise in cancer cases in coming years. Although there has been substantial advancement in cancer prevention, screening, diagnosis, and treatment over the past few decades, addressing Latino cancer health disparities has not nearly kept pace with progress. The diverse and dynamic group of speakers and panelists brought together at the Advancing the Science of Cancer in Latinos conference provided in-depth insights as well as progress and actionable goals for Latino-focused basic science research, clinical best practices, community interventions, and what can be done by way of prevention, screening, diagnosis, and treatment of cancer in Latinos. These insights have been translated into the chapters included in this compendium; the chapters summarize the presentations and include current knowledge in the specific topic areas, identified gaps, and top priority areas for future cancer research in Latinos. Topics included among the chapters: Colorectal cancer disparities in Latinos: Genes vs. Environment Breast cancer risk and mortality in women of Latin American origin Differential cancer risk in Latinos: The role of diet Overcoming barriers for Latinos on cancer clinical trials Es tiempo: Engaging Latinas in cervical cancer research Emerging policies in U.S. health care Advancing the Science of Cancer in Latinos proves to be an indispensable resource offering key insights into actionable targets for basic science research, suggestions for clinical best practices and community interventions, and novel strategies and advocacy opportunities to reduce health disparities in Latino communities. It will find an engaged audience among researchers, academics, physicians and other healthcare professionals, patient advocates, students, and others with an interest in the broad field of Latino cancer.

Improving Palliative Care for Cancer

Improving Palliative Care for Cancer
Author: National Research Council
Publisher: National Academies Press
Total Pages: 344
Release: 2001-10-19
Genre: Medical
ISBN: 0309074029

In our society's aggressive pursuit of cures for cancer, we have neglected symptom control and comfort care. Less than one percent of the National Cancer Institute's budget is spent on any aspect of palliative care research or education, despite the half million people who die of cancer each year and the larger number living with cancer and its symptoms. Improving Palliative Care for Cancer examines the barriersâ€"scientific, policy, and socialâ€"that keep those in need from getting good palliative care. It goes on to recommend public- and private-sector actions that would lead to the development of more effective palliative interventions; better information about currently used interventions; and greater knowledge about, and access to, palliative care for all those with cancer who would benefit from it.

Cancer Evolution

Cancer Evolution
Author: Charles Swanton
Publisher: Perspectives Cshl
Total Pages: 350
Release: 2017
Genre: Medical
ISBN: 9781621821434

Tumor progression is driven by mutations that confer growth advantages to different subpopulations of cancer cells. As a tumor grows, these subpopulations expand, accumulate new mutations, and are subjected to selective pressures from the environment, including anticancer interventions. This process, termed clonal evolution, can lead to the emergence of therapy-resistant tumors and poses a major challenge for cancer eradication efforts. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine examines cancer progression as an evolutionary process and explores how this way of looking at cancer may lead to more effective strategies for managing and treating it. The contributors review efforts to characterize the subclonal architecture and dynamics of tumors, understand the roles of chromosomal instability, driver mutations, and mutation order, and determine how cancer cells respond to selective pressures imposed by anticancer agents, immune cells, and other components of the tumor microenvironment. They compare cancer evolution to organismal evolution and describe how ecological theories and mathematical models are being used to understand the complex dynamics between a tumor and its microenvironment during cancer progression. The authors also discuss improved methods to monitor tumor evolution (e.g., liquid biopsies) and the development of more effective strategies for managing and treating cancers (e.g., immunotherapies). This volume will therefore serve as a vital reference for all cancer biologists as well as anyone seeking to improve clinical outcomes for patients with cancer.