Animal Models and Human Reproduction

Animal Models and Human Reproduction
Author: Heide Schatten
Publisher: John Wiley & Sons
Total Pages: 608
Release: 2017-03-20
Genre: Science
ISBN: 1118881605

Our knowledge of reproductive biology has increased enormously in recent years on cellular, molecular, and genetic levels, leading to significant breakthroughs that have directly benefitted in vitro fertilization (IVF) and other assisted reproductive technologies (ART) in humans and animal systems. Animal Models and Human Reproduction presents a comprehensive reference that reflects the latest scientific research being done in human reproductive biology utilizing domestic animal models. Chapters on canine, equine, cow, pig, frog, and mouse models of reproduction reflect frontier research in placental biology, ovarian function and fertility, non-coding RNAs in gametogenesis, oocyte and embryo metabolism, fertilization, cryopreservation, signal transduction pathways, chromatin dynamics, epigenetics, reproductive aging, and inflammation. Chapters on non-human primate models also highlight recent advancements into such issues as human in vitro fertilization (IVF) and assisted reproductive technologies (ART). This book offers animal scientists, reproductive biology scientists, clinicians and practitioners, invaluable insights into a wide range of issues at the forefront of human reproductive health.

Development and Reproduction in Humans and Animal Model Species

Development and Reproduction in Humans and Animal Model Species
Author: Werner A. Mueller
Publisher: Springer
Total Pages: 723
Release: 2015-01-03
Genre: Science
ISBN: 3662437848

This book describes human development including sexual reproduction and stem cell research with the development of model organisms that are accessible to genetic and experimental analysis in readily understandable texts and 315 multi-colored graphics. The introductory account of model organisms selected from the entire animal kingdom presents general principles, which are then outlined in subsequent chapters devoted to, for example, sexual development; genes controlling development and their contemporary molecular-analysis methods; production of clones and transgenic animals; development of the nervous and circulatory systems; regenerative medicine and ageing. Finally the evolution of developmental toolkits and novelties is discussed including the genetic basis of the enlargement of the human forebrain. Separate boxes are devoted to controversial questions such as the benefits and problems of prenatal diagnostics or the construction of ancient body plans.

Reproductive Technologies in Animals

Reproductive Technologies in Animals
Author: Giorgio Presicce
Publisher: Academic Press
Total Pages: 307
Release: 2020-05-28
Genre: Technology & Engineering
ISBN: 0128171081

Reproductive Technologies in Animals provides the most updated and comprehensive knowledge on the various aspects and applications of reproductive technologies in production animals as well as companion, wild, exotic, and laboratory animals and birds. The text synthesizes historical information and recent discoveries, while dealing with economical and geographical issues related to the implementation of the same technologies. It also presents the effects of reproductive technology implementation on animal welfare and the possible threat of pathogen transmission.Reproductive Technologies in Animals is an important resource for academics, researchers, professionals in public and private animal business, and students at the undergraduate and graduate levels, as it gives a full and detailed first-hand analysis of all species subjected to the use of reproductive technologies. - Provides research from a team of scientists and researchers whose expertise spans all aspects of animal reproductive technologies - Addresses the use of reproductive technologies in a wide range of animal species - Offers a complete description and historical background for each species described - Discusses successes and failure as well as future challenges in reproductive technologies

Scientific and Medical Aspects of Human Reproductive Cloning

Scientific and Medical Aspects of Human Reproductive Cloning
Author: National Research Council
Publisher: National Academies Press
Total Pages: 295
Release: 2002-06-17
Genre: Science
ISBN: 0309076374

Human reproductive cloning is an assisted reproductive technology that would be carried out with the goal of creating a newborn genetically identical to another human being. It is currently the subject of much debate around the world, involving a variety of ethical, religious, societal, scientific, and medical issues. Scientific and Medical Aspects of Human Reproductive Cloning considers the scientific and medical sides of this issue, plus ethical issues that pertain to human-subjects research. Based on experience with reproductive cloning in animals, the report concludes that human reproductive cloning would be dangerous for the woman, fetus, and newborn, and is likely to fail. The study panel did not address the issue of whether human reproductive cloning, even if it were found to be medically safe, would beâ€"or would not beâ€"acceptable to individuals or society.

Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease
Author: P. Michael Conn
Publisher: Academic Press
Total Pages: 1109
Release: 2013-05-29
Genre: Science
ISBN: 0124159125

Animal Models for the Study of Human Disease identifies important animal models and assesses the advantages and disadvantages of each model for the study of human disease. The first section addresses how to locate resources, animal alternatives, animal ethics and related issues, much needed information for researchers across the biological sciences and biomedicine.The next sections of the work offers models for disease-oriented topics, including cardiac and pulmonary diseases, aging, infectious diseases, obesity, diabetes, neurological diseases, joint diseases, visual disorders, cancer, hypertension, genetic diseases, and diseases of abuse. - Organized by disease orientation for ease of searchability - Provides information on locating resources, animal alternatives and animal ethics - Covers a broad range of animal models used in research for human disease

Scientific Frontiers in Developmental Toxicology and Risk Assessment

Scientific Frontiers in Developmental Toxicology and Risk Assessment
Author: National Research Council
Publisher: National Academies Press
Total Pages: 348
Release: 2000-12-21
Genre: Nature
ISBN: 0309070864

Scientific Frontiers in Developmental Toxicology and Risk Assessment reviews advances made during the last 10-15 years in fields such as developmental biology, molecular biology, and genetics. It describes a novel approach for how these advances might be used in combination with existing methodologies to further the understanding of mechanisms of developmental toxicity, to improve the assessment of chemicals for their ability to cause developmental toxicity, and to improve risk assessment for developmental defects. For example, based on the recent advances, even the smallest, simplest laboratory animals such as the fruit fly, roundworm, and zebrafish might be able to serve as developmental toxicological models for human biological systems. Use of such organisms might allow for rapid and inexpensive testing of large numbers of chemicals for their potential to cause developmental toxicity; presently, there are little or no developmental toxicity data available for the majority of natural and manufactured chemicals in use. This new approach to developmental toxicology and risk assessment will require simultaneous research on several fronts by experts from multiple scientific disciplines, including developmental toxicologists, developmental biologists, geneticists, epidemiologists, and biostatisticians.

Hormonally Active Agents in the Environment

Hormonally Active Agents in the Environment
Author: National Research Council
Publisher: National Academies Press
Total Pages: 453
Release: 2000-02-03
Genre: Science
ISBN: 0309064198

Some investigators have hypothesized that estrogens and other hormonally active agents found in the environment might be involved in breast cancer increases and sperm count declines in humans as well as deformities and reproductive problems seen in wildlife. This book looks in detail at the science behind the ominous prospect of "estrogen mimics" threatening health and well-being, from the level of ecosystems and populations to individual people and animals. The committee identifies research needs and offers specific recommendations to decision-makers. This authoritative volume: Critically evaluates the literature on hormonally active agents in the environment and identifies known and suspected toxicologic mechanisms and effects of fish, wildlife, and humans. Examines whether and how exposure to hormonally active agents occursâ€"in diet, in pharmaceuticals, from industrial releases into the environmentâ€"and why the debate centers on estrogens. Identifies significant uncertainties, limitations of knowledge, and weaknesses in the scientific literature. The book presents a wealth of information and investigates a wide range of examples across the spectrum of life that might be related to these agents.

Evaluating Chemical and Other Agent Exposures for Reproductive and Developmental Toxicity

Evaluating Chemical and Other Agent Exposures for Reproductive and Developmental Toxicity
Author: National Research Council
Publisher: National Academies Press
Total Pages: 261
Release: 2001-04-13
Genre: Nature
ISBN: 0309073162

The United States Navy has been concerned for some time with protecting its military and civilian personnel from reproductive and developmental hazards in the workplace. As part of its efforts to reduce or eliminate exposure of Naval personnel and their families to reproductive and developmental toxicants, the Navy requested that the National Research Council (NRC) recommend an approach that can be used to evaluate chemicals and physical agents for their potential to cause reproductive and developmental toxicity. The NRC assigned this project to the Committee on Toxicology, which convened the Subcommittee on Reproductive and Developmental Toxicology, to prepare this report. In this report, the subcommittee recommends an approach for evaluating agents for potential reproductive and developmental toxicity and demonstrates how that approach can be used by the Navy. This report has been reviewed in draft form by individuals chosen for their diverse perspectives and technical expertise, in accordance with procedures approved by the NRC's Report Review Committee. The purpose of this independent review is to provide candid and critical comments that will assist the institution in making its published report as sound as possible and to ensure that the report meets institutional standards for objectivity, evidence, and responsiveness to the study charge. The review comments and draft manuscript remain confidential to protect the integrity of the deliberative process. We wish to thank the following individuals for their review of this report: James Chen (National Center for Toxicological Research), George Daston (Procter and Gamble Company), Jerry Heindel (National Institute of Environmental Health Sciences), Grace Lemasters (University of Cincinnati), and John Young (National Center for Toxicological Research).

Use of Laboratory Animals in Biomedical and Behavioral Research

Use of Laboratory Animals in Biomedical and Behavioral Research
Author: National Research Council
Publisher: National Academies Press
Total Pages: 113
Release: 1988-02-01
Genre: Science
ISBN: 0309038391

Scientific experiments using animals have contributed significantly to the improvement of human health. Animal experiments were crucial to the conquest of polio, for example, and they will undoubtedly be one of the keystones in AIDS research. However, some persons believe that the cost to the animals is often high. Authored by a committee of experts from various fields, this book discusses the benefits that have resulted from animal research, the scope of animal research today, the concerns of advocates of animal welfare, and the prospects for finding alternatives to animal use. The authors conclude with specific recommendations for more consistent government action.

Physiology of Human Reproduction

Physiology of Human Reproduction
Author: George Osol
Publisher: John Wiley & Sons
Total Pages: 112
Release: 2021-03-22
Genre: Medical
ISBN: 1119609585

Physiology of Human Reproduction provides students with a concise and accessible overview of more than 200 vital concepts, from the basic physiology of the male and the nonpregnant female, to fertilization, embryonic and fetal growth, labor, lactation, and more. Presented in a readable style, key terms are highlighted throughout the main text to enable students to quickly find a concept and read the appropriate information. Whether reading the book from cover to cover, or using a focused approach to learn about specific concepts, readers will find this textbook to be an invaluable tool for increasing their understanding of human reproduction. An essential companion for standard Anatomy and Physiology courses, this student-friendly textbook: Covers physiology of the male, the physiology of the nonpregnant female, pregnancy and lactation, and age-related changes such as menopause Discusses pregnancy, birth control, and the reproductive system in childhood, adolescence, and puberty Describes the anatomy, physiology, and phases of the human sexual response Explains genetic conditions and disorders including androgen insensitivity syndrome and Kallman’s syndrome Physiology of Human Reproduction is a must-have learning guide for students in the medical and life sciences, including medicine, nursing, biology, physiology, and biomedicine, as well as those in courses covering human reproduction and pregnancy.