Ancistrocladus Naphthylisoquinoline Alkaloids
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| Author | : A. Douglas Kinghorn |
| Publisher | : Springer Nature |
| Total Pages | : 344 |
| Release | : 2023-01-01 |
| Genre | : Science |
| ISBN | : 3031104579 |
This book describes a unique class of secondary metabolites, the mono- and dimeric-naphthylisoquinoline alkaloids. They exclusively occur in lianas of the palaeotropical Ancistrocladaceae and Dioncophyllaceae plant families. Their unprecedented structures include stereogenic centers and rotationally hindered, and therefore stereogenic, axes. Extended recent investigations on six Ancistrocladus species from Asia, as reported in this contribution, shed light on their fascinating phytochemical productivity, with over 100 intriguing natural products. This high chemodiversity arises from a similarly unique biosynthesis from acetate-malonate units, following a novel polyketidic pathway to plant-derived isoquinoline alkaloids. Some of the compounds show most promising anti-parasitic activities. Additionally, strategies for the regio- and stereoselective total synthesis of the alkaloids, including the directed construction of the chiral axis, are also presented.
| Author | : |
| Publisher | : Elsevier |
| Total Pages | : 446 |
| Release | : 2024-05-27 |
| Genre | : Science |
| ISBN | : 0443295557 |
The Alkaloids: Chemistry and Biology, Volume 91, the newest release in a series that has covered the topic for more than 60 years, discusses key aspects of alkaloid chemistry, biology and pharmacology. Sections in this release include chapters on Recent Progress in the Chemistry of Naphthylisoquinoline Alkaloids. - Provides the latest information on the study of alkaloids - Covers alkaloid chemistry, biology, pharmacology, and medical applications - Contains more than 80 published volumes in this interesting field of study
| Author | : Margaret F. Roberts |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 492 |
| Release | : 2013-04-17 |
| Genre | : Science |
| ISBN | : 1475729057 |
Not since the late 1970s has a single work presented the biology of this heterogenous group of secondary alkaloids in such depth. Alkaloids, a unique treatise featuring leaders in the field, presents both the historical use of alkaloids and the latest discoveries in the biochemistry of alkaloid production in plants alkaloid ecology, including marine invertebrates, animal and plant parasites, and alkaloids as antimicrobial and current medicinal use . Highlights include chapters on the chemical ecology of alkaloids in host-predator interactions, and on the compartmentation of alkaloids synthesis, transport, and storage. Extensive cross-referencing in tabular format makes this volume an excellent reference.
| Author | : Da-Cheng Hao |
| Publisher | : Academic Press |
| Total Pages | : 406 |
| Release | : 2018-04-23 |
| Genre | : Medical |
| ISBN | : 0128142332 |
Ranunculales Medicinal Plants: Biodiversity, Chemodiversity and Pharmacotherapy comprehensively covers this order of flowering plants, detailing the phytochemistry, chemotaxonomy, molecular biology, and phylogeny of selected medicinal plants families and genera and their relevance to drug efficacy. The book carries out an exhaustive survey of the literature in order to characterize global trends in the application of flexible technologies. The interrelationship between Chinese species, and between Chinese and non-Chinese species, is inferred through molecular phylogeny and based on nuclear and chloroplast DNA sequencing. The book discusses the conflict between chemotaxonomy and molecular phylogeny in the context of drug discovery and development. Users will find invaluable and holistic coverage on the study of Ranunculales that will make this the go-to pharmaceutical resource. - Describes current perceptions of biodiversity and chemodiversity of Ranunculales - Explains how the conceptual framework of plant pharmacophylogeny benefits the sustainable exploitation of Ranunculales - Details how Ranunculales medicinal plants work from the chemical level upward - Covers how the polypharmacology of Ranunculales compounds might inspire new chemical entity design and development for improved treatment outcomes
| Author | : Jose M Lassaletta |
| Publisher | : World Scientific |
| Total Pages | : 676 |
| Release | : 2019-05-23 |
| Genre | : Science |
| ISBN | : 1786346478 |
Chapter contribution from Ben Feringa, Nobel Laureate in Chemistry 2016.Atropisomerism and Axial Chirality provides a global survey of the chemistry of axially chiral compounds including biaryls, heterobiaryls, non-biaryl atropisomers, allenes and spyrocyclic derivatives. From the perspective of a synthetic organic chemist, this book provides a unique compilation of the available methodologies for their synthesis, with emphasis on the most efficient and modern strategies, a review of the huge amount of practical applications in the field of asymmetric catalysis, either as transition metal ligands or as organocatalysts, and an overview of their occurrence as bioactive compounds and natural products.The first of its kind, this book serves as a general introduction and a practical reference to advanced chemistry students and researchers, while also offering creative ideas for further developments in the field.
| Author | : Goutam Brahmachari |
| Publisher | : Elsevier |
| Total Pages | : 461 |
| Release | : 2019-04-15 |
| Genre | : Science |
| ISBN | : 0128157240 |
Discovery and Development of Therapeutics from Natural Products against Neglected Tropical Diseases draws together research on medicinal agents from natural sources as starting points for the design of drugs against Neglected Tropical Diseases (NTDs). From the prediction of promising leads and identification of active agents, to the extraction of complex molecules, the book explores novel, economical and efficacious therapeutics for these diseases. It describes current research and the role of natural products, antimalarial compounds from marine natural products and sesquiterpene lactones, natural antileprotic agents, natural products with potential against Leishmaniasis, Trypanosomiasis and Dengue, and more. In addition, Quinoline and Isoquinoline alkaloids for developing new antiprotozoal agents are discussed, alongside anti-trypanosomatid heterocyclic compounds as structures for development. Combining the expertise of specialists from around the world, this volume aims to support and encourage researchers in the investigation of natural sources as starting points for the development of novel, safe and effective agents for use against neglected tropical diseases. - Includes chapters written by active researchers and leading global experts deeply engaged in the research field of natural product chemistry for drug discovery - Draws together cutting-edge research advances in natural product chemistry that are targeted at neglected tropical diseases - Highlights the future potential of natural products as sources of novel medicinal compounds against neglected tropical diseases
| Author | : Christophe Wiart |
| Publisher | : World Scientific |
| Total Pages | : 756 |
| Release | : 2006-01-11 |
| Genre | : Medical |
| ISBN | : 9814480339 |
This invaluable book provides a readable, introductory text to the fascinating subject of drug discovery from the medicinal plants of Asia-Pacific. A carefully designed layout presents more than 400 medicinal plants, and includes description of compound structure, molecular properties, pharmacology and clinical uses. With its broad scope and extensive compound listings, this is a premier reference source for natural products research using a pharmacological approach. Starting from a collection of plants in the rainforests of Asia-Pacific, Wiart shows how the present state of knowledge fosters a whole new way of looking at the discovery of drugs from medicinal plants.Wiart uses his approach to deal with a remarkable array of fundamental problems: from the phylogeny of plants, to the molecular basis of activity, limitations of phytochemistry, and the possibility of a truly fundamental theory of ethnopharmacology.Written with exceptional clarity, and illustrated by more than 300 original pictures and 400 chemical structures, this seminal book allows scientists and non-scientists alike to participate in what promises to be a major intellectual revolution.
| Author | : |
| Publisher | : Elsevier |
| Total Pages | : 672 |
| Release | : 2024-06-18 |
| Genre | : Science |
| ISBN | : 0443293392 |
African Plant-Based Products as a Source of Potent Drugs to Overcome Cancers and their Chemoresistance: Part One: Cancer Chemoresistance, Screening, Methods, and the Updated cut-off Points for the Classification of Natural Cytotoxic Products, Volume 111 offers an overview of the potential of African medicinal plants as a source of anticancer agents to overcome with an emphasis on cancer drug resistance. Based on the collected data, the book also offers a rational classification basis for the cytotoxic activity of natural products. The general knowledge of state-of-the-art of cancer drug resistance globally and the screening methods for cytotoxic agents are described.This book clearly identifies the best African medicinal plants that could be useful for the development of efficient herbal drugs, as well as the best phytochemicals that could be explored as potential pharmaceuticals to efficiently tackle cancers and their refractory phenotypes. The book appears a unique tool for Scientists for anticancer drug discovery from the exceptional flora of Africa. - Provides the first of its type reference to focus on the potential of African plants as an alternative medicine to tackle cancers and their recalcitrant phenotypes - Analyzes the recorded data to propose a rational basis for the classification of naturally occurring cytotoxic agents - Clearly identifies and discusses plants and phytochemicals that could be useful in the development of new cytotoxic drugs to overcome cancer and cancer drug resistance
| Author | : Liliana Mammino |
| Publisher | : Springer Nature |
| Total Pages | : 472 |
| Release | : 2020-02-05 |
| Genre | : Science |
| ISBN | : 3030349411 |
This edited, multi-author book gathers selected, peer-reviewed contributions based on papers presented at the 23rd International Workshop on Quantum Systems in Chemistry, Physics, and Biology (QSCP-XXIII), held in Mopani Camp, The Kruger National Park, South Africa, in September 2018. The content is primarily intended for scholars, researchers, and graduate students working at universities and scientific institutes who are interested in the structure, properties, dynamics, and spectroscopy of atoms, molecules, biological systems, and condensed matter.
| Author | : A. Douglas Kinghorn |
| Publisher | : Springer |
| Total Pages | : 0 |
| Release | : 2022-11-22 |
| Genre | : Science |
| ISBN | : 9783031104565 |
This book describes a unique class of secondary metabolites, the mono- and dimeric-naphthylisoquinoline alkaloids. They exclusively occur in lianas of the palaeotropical Ancistrocladaceae and Dioncophyllaceae plant families. Their unprecedented structures include stereogenic centers and rotationally hindered, and therefore stereogenic, axes. Extended recent investigations on six Ancistrocladus species from Asia, as reported in this contribution, shed light on their fascinating phytochemical productivity, with over 100 intriguing natural products. This high chemodiversity arises from a similarly unique biosynthesis from acetate-malonate units, following a novel polyketidic pathway to plant-derived isoquinoline alkaloids. Some of the compounds show most promising anti-parasitic activities. Additionally, strategies for the regio- and stereoselective total synthesis of the alkaloids, including the directed construction of the chiral axis, are also presented.
