An Updated View On An Emerging Target Selected Papers From The 8th International Conference On Protein Kinase Ck2
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Author | : Joachim Jose |
Publisher | : MDPI |
Total Pages | : 321 |
Release | : 2017-05-22 |
Genre | : Medical |
ISBN | : 3038424129 |
This book is a printed edition of the Special Issue "An Updated View on an Emerging Target: Selected Papers from the 8th International Conference on Protein Kinase CK2" that was published in Pharmaceuticals
Author | : Khalil Ahmed |
Publisher | : Springer Science & Business Media |
Total Pages | : 200 |
Release | : 2002-06-30 |
Genre | : Gardening |
ISBN | : 9780792376668 |
Signal Transduction through phosphorylation and dephosphorylation of proteins in the cell is now a well-recognized mechanism involved in countless physiological and pathological processes. Consequently, the enzymes, known as protein kinases, which catalyze the phosphorylation of proteins, are critical regulators of cellular events. One of these protein kinases is the protein kinase CK2 (also known as casein kinase 2) that has been implicated in multiple functions including control of cell growth and proliferation. CK2 is a protein serine/threonine kinase which is a highly conserved and ubiquitous protein kinase. It is localized in the cytoplasmic and nuclear compartments, which accords with its multiple functional activities in the cell. Pertinent to this is also the recognition that a large number of putative substrates for this kinase have been identified in various compartments of the cell. New evidence from several laboratories has further reinforced the involvement of CK2 in signal transduction related to many cellular functions, thus underscoring the significance of its functional role in normal and abnormal cell growth and proliferation. This volume provides an overview of the state of knowledge concerning this intriguing protein kinase. It brings together contributions from leading investigators engaged in research in this field. Key developments during the past three years pertain to the elaboration of the crystal structure and definition of novel functions of the kinase, such as its role as an inhibitor of apoptosis. Additionally, the shuttling of the kinase to various compartments in response to physiological and stress stimuli appears to be a key feature of the functional regulation of its activity in the cell.
Author | : Joëlle Roche |
Publisher | : MDPI |
Total Pages | : 261 |
Release | : 2018-04-09 |
Genre | : Science |
ISBN | : 3038427934 |
This book is a printed edition of the Special Issue "The Epithelial-to-Mesenchymal Transition (EMT) in Cancer" that was published in Cancers
Author | : 978-3-03842-836-7 |
Publisher | : MDPI |
Total Pages | : 247 |
Release | : 2018-07-04 |
Genre | : Medical |
ISBN | : 3038428353 |
This book is a printed edition of the Special Issue "Glycosaminoglycans and Proteoglycans" that was published in Pharmaceuticals
Author | : Antonis Zampelas |
Publisher | : CRC Press |
Total Pages | : 387 |
Release | : 2015-06-09 |
Genre | : Health & Fitness |
ISBN | : 100021902X |
Antioxidant use in health promotion and disease prevention either through dietary intake or supplementation is controversial. This book reviews the latest evidence-based research in the area, principally through prospective cohort studies and randomized controlled trials. It assesses major dietary antioxidants and discusses their use in diseases such as cancer, diabetes, stroke, coronary heart disease, HIV/AIDS, and neurodegenerative and immune diseases. The use of antioxidants in health is also discussed along with common adverse effects associated with antioxidant use.
Author | : James E. Barrett |
Publisher | : Springer Nature |
Total Pages | : 457 |
Release | : 2019-12-24 |
Genre | : Medical |
ISBN | : 3030353621 |
Celebrating 100 years of HEP, this volume will discuss key pharmacological discoveries and concepts of the past 100 years. These discoveries have dramatically changed the medical treatment paradigms of many diseases and these concepts have and will continue to shape discovery of new medicinies. Newly evolving technologies will similarly be discussed as they will shape the future of the pharmacology and, accordingly, medical therapy.
Author | : Vasilis Vasiliou |
Publisher | : Springer |
Total Pages | : 274 |
Release | : 2018-10-26 |
Genre | : Medical |
ISBN | : 3319987887 |
Following the Third Alcohol and Cancer Conference, this volume compiles the most up-to-date research on the role of alcohol consumption in carcinogenesis, from epidemiology to pathology metabolism and stem cells. More specifically, it delves into the effects of alcohol consumption and thyroid cancer, CD133+ progenitor cells, carcinogenic iron accumulation, developmental morphogens, and cancer-inducing epigenetic changes. Alcohol and Cancer: Proceedings of the Third International Conference is a timely update to Biological Basis of Alcohol-Induced Cancer, which followed the Second Alcohol and Cancer Conference, compiling cutting-edge research from graduate students, young scientists, and researchers. It is ideal for graduate students and researchers in oncology, hepatology, epigenetics, and alcohol consumption.
Author | : Stanley Stylli |
Publisher | : Mdpi AG |
Total Pages | : 282 |
Release | : 2021-12-21 |
Genre | : |
ISBN | : 9783036525990 |
This book is a compilation of articles that brings together current knowledge from an international team of contributors who are dedicated investigators exploring novel strategies for the treatment of glioblastoma. These articles describe some of the latest concepts that will provide students, researchers and clinicians with an overview of the therapeutic approaches being developed in the field of neuro-oncology to combat this deadly disease.
Author | : Sangeeta Saxena |
Publisher | : Springer |
Total Pages | : 332 |
Release | : 2017-10-14 |
Genre | : Science |
ISBN | : 9811059845 |
Begomoviruses are one of the most interesting plant viruses to study for basic and applied research as they cause huge economic losses to agriculture industries and farmers all over the world. They belong to family Geminiviridae and are emergent plant viral pathogens which cause diseases in various crops in the tropical and subtropical regions. They are transmitted by the whitefly (B. tabaci) and have either one (monopartite DNA-A) or two (bipartite DNA-A and DNA-B) genomic components. DNA-A and DNA-B are of ~2600 - 2800 nucleotides each. A number of serious diseases of cultivated crops of the Fabaceae, Malvaceae, Solanaceae and Cucurbitaceae families are caused by Begomoviruses which are considered as threat to their cultivation in many countries. Accurate diagnosis is important for successful diseases management, since plants infected by Begomovirus do not recover, suffer serious yield losses and act as further sources of inoculum, which is then picked up and spread by their vector whitefly (B. tabaci). Reports of occurrence of new viruses and re-emergence of several known viruses in new niches have become regular event. In such a dynamic system, growth of several crop species relies on an accurate diagnosis, management and better understanding of the biology of the casual virus. This is crucial to evolve appropriate control practices and to prevent the virus infection. Researchers have achieved considerable progress in characterization, detection and management of virus on different crop species in the last decade. This book covers latest information in diagnosis of begomoviruses in the present scenario and explores the new vistas in the field of genomics and proteomics. Chapters in Section 1 illustrates the occurrence, genome organisation, transmission and diagnostics of begomoviruses. It also details the diseases caused by begomoviruses on different crops, detection techniques and management strategies in support of research findings by presentation of data, graphics, figures and tables. Section 2 is a chapterwise collection of occurrence, diversity and status of begomoviruses in Asian Africa counties where the diseases are most prevalent. This book will provide wide opportunity to the readers to have complete information and status of begomovirus in Asia and Africa. This will be useful resource for researchers and extension workers involved in the begomvirus disease diagnosis and molecular biology. Expert detection, accurate diagnosis and timely management play a significant role in keeping plants free from pathogens. In this book expert researchers share their research knowledge and literature which are vital towards the diagnosis of begomoviruses, addressing traditional plant pathology techniques as well as advanced molecular diagnostic approach. The book deals with the economically important crops including fruits, vegetables along with challenges in crop protection against diseases caused by begomovirus. This will be resourceful and handy for researcher, practitioners and also students.
Author | : Vincenzo Zappia |
Publisher | : Springer Science & Business Media |
Total Pages | : 313 |
Release | : 2013-03-09 |
Genre | : Medical |
ISBN | : 1475732309 |
This volume includes contributions presented at the Second International Sym posium on Nutrition and Cancer, held in Naples, Italy, in October 1998 at the National Tumor Institute "Fondazione Pascale." During the Conference, experts from different disciplines discussed pivotal and timely subjects on the interactions between human nutrition and the development of malignancies. Comparing the themes of this Meeting with those discussed at the First Sympo sium in 1992, the major scientific advancements certainly derive from the extensive use of molecular approaches to perform research in nutrition. Moreover, the fundamental observation of R. Doll and R. Peto (1981), which suggested that at least 35% of all cancers (with large differences among different tumors) might be prevented by dietary regimens, has been definitively confirmed by epidemiological studies. On the other hand, the relationships between diet and cancer are quite intricate and complex; it is difficult, and at the same time not methodologically correct, to reduce them to simple terms. Metabolic and hormonal factors, contaminants and biological agents, and deficiency of specific protective nutrients are all pieces of the same puzzle.