An Update On Neurological Disorders Post Covid 19 Infection
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| Author | : Beatrice Paradiso |
| Publisher | : Frontiers Media SA |
| Total Pages | : 126 |
| Release | : 2023-08-02 |
| Genre | : Medical |
| ISBN | : 2832531318 |
Coronavirus disease 2019 (COVID-19), produces the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with atypical pneumonia. This infection is a global health challenge producing post-acute sequelae of SARS-CoV-2 infection (PASC), including neuro-PASC in which direct or indirect invasion of the virus into the brain causes immune dysregulation, hormonal disorders, elevated cytokine levels due to immune reaction and chronic inflammation, direct tissue injury, and persistent low-grade infection. The COVID-19 induced-neuroinflammation promotes blood-brain barrier (BBB) disruption, access of antigens and inflammatory factors into the brain, as well as infection or immune-mediated response in the neuromuscular system. It is therefore necessary to explore whether there is a close correlation with the adenosine pathway, the activation of the ACE receptor by the virus, the concentration of IL6 and the neuro-invasive effect of COVID-19. Other points of interest are the analysis of the autonomic dysfunction induced by cytokines; the effect of vaccine mRNA delivery in Central and Peripheral Nervous System, the long-term effects of Covid 19 infection and/or therapeutic approach in different pandemic countries. In this Research Topic we aim to including submissions and research from different countries, which will allow comparisons of loco-regional clinical experiences, diagnostic flow-charts, and different therapeutic approaches.
| Author | : |
| Publisher | : World Scientific |
| Total Pages | : 125 |
| Release | : 2020-06-16 |
| Genre | : Medical |
| ISBN | : 9811223092 |
A novel public health concept, the Fangcang Shelter Hospital was first proposed by Professor Wang Chen, an academician of Chinese Academy of Engineering, in Wuhan, China, in February 2020. While responding to the coronavirus disease 2019 (COVID-19) outbreak, medical staff faced the pressing situation of limited medical supplies, which led Professor Wang Chen to the suggestion of converting large-scale public venues such as exhibition centers and indoor stadiums into shelter hospitals to receive large number of patients, as this involved minimum time and monetary costs. The five essential functions of Fangcang Shelter Hospitals (isolation, triage, provision of basic medical care, frequent monitoring and rapid referral, and essential living and social engagement) enable shelter hospitals to receive patients with mild to moderate symptoms of COVID-19, and have the greatest impact on isolating the source of infection and expanding the area's health-care capacity.Two of the first three Fangcang Shelter Hospitals set up in Wuhan were redeveloped by Zall Group Property from existing buildings, while Zall Foundation was responsible for the provision of essential medical supplies and logistical support to facilitate the running of these shelter hospitals. In total, the two shelter hospitals have been instrumental in diagnosing, treating and curing 3663 patients. Under the medical expertise and guidance of Professor Wang Chen, as well as inputs from Zall Foundation's crews who contributed to the design, renovation and operation of these shelter hospitals, this manual encompasses knowledge and experience distilled from the running of these Fangcang Shelter Hospitals. Covering five important aspects, namely the proposal, design, renovation, operation, and logistical support for shelter hospitals, this booklet aims to be a useful reference for other epidemic prevention and control efforts in regions around the world. The manual has been translated into more than 20 languages.
| Author | : Peter G. E. Kennedy |
| Publisher | : Butterworth-Heinemann |
| Total Pages | : 304 |
| Release | : 1987 |
| Genre | : Medical |
| ISBN | : |
Infections of the Nervous System aims to continue the legacy of its predecessor, Modern Trends in Neurology. Its goal is to produce annually a monograph on a topic in clinical neurology in which progress through research has brought about new concepts of patient management. This book is organized into 13 chapters. It highlights the areas or subjects in which significant advances have been made which also have relevance to the treatment of patients. It covers a number of important aspects of different infectious diseases of the nervous system including acute bacterial meningitis, tuberculosis o ...
| Author | : Bashar Katirji |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 1565 |
| Release | : 2013-10-11 |
| Genre | : Medical |
| ISBN | : 1461465672 |
Comprehensive, thoroughly updated, and expanded, Neuromuscular Disorders in Clinical Practice, Second Edition encompasses all disorders of the peripheral nervous system, covering all aspects of neuromuscular diseases from diagnosis to treatment. Mirroring the first book, this two-volume edition is divided into two parts. Part one discusses the approach to neuromuscular disorders, covering principles and basics, neuromuscular investigations, and assessment and treatment of neurological disorders. Part two then addresses the complete range of specific neuromuscular diseases: neuronopathies, peripheral neuropathies, neuromuscular junction disorders, muscle ion channel disorders, myopathies, and miscellaneous neuromuscular disorders and syndromes. Neuromuscular Disorders in Clinical Practice, Second Edition is intended to serve as a comprehensive text for both novice and experienced practitioners. General neurologists as well as specialists in neuromuscular medicine and trainees in neuromuscular medicine, clinical neurophysiology and electromyography should find this book inclusive, comprehensive, practical and highly clinically focused. Additionally, specialists in physical medicine and rehabilitation, rheumatology, neurosurgery, and orthopedics will find the book of great value in their practice.
| Author | : Valentin A. Pavlov |
| Publisher | : Frontiers Media SA |
| Total Pages | : 222 |
| Release | : 2018-07-24 |
| Genre | : |
| ISBN | : 2889455335 |
The nervous system plays an important role in the regulation of immunity and inflammation. On the other hand unbalanced immune responses in inflammatory and autoimmune conditions may have a deleterious impact on neuronal integrity and brain function. Recent studies have characterized neural pathways communicating peripheral inflammatory signals to the CNS, and brain- and spinal cord-derived circuitries controlling various innate and adaptive immune responses and inflammation. A prototypical neural reflex circuit that regulates immunity and inflammation is the vagus nerve-based “inflammatory reflex”. Ongoing research has revealed cellular and molecular mechanisms underlying these neural circuits and indicated new therapeutic approaches in inflammatory and autoimmune disorders. Pharmacological and bioelectronic modulation of neural circuitry has been successfully explored in preclinical settings of sepsis, arthritis, inflammatory bowel disease, obesity-driven disorders, diabetes and other diseases. These studies paved the way to successful clinical trials with bioelectronic neuronal modulation in rheumatoid arthritis and inflammatory bowel disease. Dysregulated release of cytokines and other inflammatory molecules may have a severe impact on brain function. Brain inflammation (neuroinflammation), imbalances in brain neuronal integrity and neurotransmitter systems, and cognitive impairment are characteristic features of post-operative conditions, sepsis, liver diseases, diabetes and other disorders characterized by immune and metabolic dysregulation. Derangements in cytokine release also play a pivotal role in depression. Characteristic brain reactive antibodies in autoimmune conditions, including systemic lupus erythematosus and neuromyelitis optica, significantly contribute to brain pathology and cognitive impairment. These studies, and the simultaneous characterization of neuro-protective cytokines, identified new therapeutic approaches for treating neurological complications in inflammatory and autoimmune disorders. This Frontiers Research Topic is a forum for publishing research findings and methodological and conceptual advances at the intersection of immunology and neuroscience. We hope that presenting new insight into bi-directional neuro-immune communication in inflammation and autoimmunity will foster further collaborations and facilitate the development of new efficient therapeutic strategies.
| Author | : Ehud Lavi |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 892 |
| Release | : 2008-01-03 |
| Genre | : Medical |
| ISBN | : 0387255184 |
Multiple Sclerosis (MS) is an enigmatic immune mediated disease of the central nervous system that affects about 350,000 individuals in the US, and many more around the world. The mechanism of this disease is largely unknown and there is no cure for it. However, there are several well-characterized experimental animal models that help us understand and speculate about potential mechanisms of pathology in this disease. Many of the experimental therapies designed for this disease rely on testing the drugs in animal models before using it in clinical trials. This book combines for the first time the different experimental models for MS (including immune-mediated and viral) under one roof, and highlights aspects that are different or shared among these experimental models. It’s aim is to improve our understanding of this devastating disease and help us think about potential additional therapies for it.
| Author | : M. Filippi |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 233 |
| Release | : 2008-02-01 |
| Genre | : Medical |
| ISBN | : 8847003911 |
Written by world-renowned scientists, the volume provides a state-of-the-art on the most recent MRI techniques related to MS, and it is an indispensable tool for all those working in this field. The context in which this book exists is that there is an increasing perception that modern MR methodologies should be more extensively employed in clinical trials to derive innovative information.
| Author | : Mohamed Boutjdir |
| Publisher | : Frontiers Media SA |
| Total Pages | : 263 |
| Release | : 2020-01-30 |
| Genre | : |
| ISBN | : 2889633977 |
| Author | : Robert W. Baloh |
| Publisher | : Springer Nature |
| Total Pages | : 203 |
| Release | : 2020-03-19 |
| Genre | : Medical |
| ISBN | : 3030407462 |
It is one of the most extraordinary cases in the history of science: the mating calls of insects were mistaken for a “sonic weapon” that led to a major diplomatic row. Since August 2017, the world media has been absorbed in the “attack” on diplomats from the American and Canadian Embassies in Cuba. While physicians treating victims have described it as a novel and perplexing condition that involves an array of complaints including brain damage, the authors present compelling evidence that mass psychogenic illness was the cause of “Havana Syndrome.” This mysterious condition that has baffled experts is explored across 11-chapters which offer insights by a prominent neurologist and an expert on psychogenic illness. A lively and enthralling read, the authors explore the history of similar scares from the 18th century belief that sounds from certain musical instruments were harmful to human health, to 19th century cases of “telephone shock,” and more contemporary panics involving people living near wind turbines that have been tied to a variety of health complaints. The authors provide dozens of examples of kindred episodes of mass hysteria throughout history, in addition to psychosomatic conditions and even the role of insects in triggering outbreaks. Havana Syndrome: Mass Psychogenic Illness and the Real Story Behind the Embassy Mystery and Hysteria is a scientific detective story and a case study in the social construction of mass psychogenic illness.
| Author | : Institute of Medicine |
| Publisher | : National Academies Press |
| Total Pages | : 251 |
| Release | : 2015-03-16 |
| Genre | : Medical |
| ISBN | : 0309316928 |
Myalgic encephalomyelitis (ME) and chronic fatigue syndrome (CFS) are serious, debilitating conditions that affect millions of people in the United States and around the world. ME/CFS can cause significant impairment and disability. Despite substantial efforts by researchers to better understand ME/CFS, there is no known cause or effective treatment. Diagnosing the disease remains a challenge, and patients often struggle with their illness for years before an identification is made. Some health care providers have been skeptical about the serious physiological - rather than psychological - nature of the illness. Once diagnosed, patients often complain of receiving hostility from their health care provider as well as being subjected to treatment strategies that exacerbate their symptoms. Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome proposes new diagnostic clinical criteria for ME/CFS and a new term for the illness - systemic exertion intolerance disease(SEID). According to this report, the term myalgic encephalomyelitis does not accurately describe this illness, and the term chronic fatigue syndrome can result in trivialization and stigmatization for patients afflicted with this illness. Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome stresses that SEID is a medical - not a psychiatric or psychological - illness. This report lists the major symptoms of SEID and recommends a diagnostic process.One of the report's most important conclusions is that a thorough history, physical examination, and targeted work-up are necessary and often sufficient for diagnosis. The new criteria will allow a large percentage of undiagnosed patients to receive an accurate diagnosis and appropriate care. Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome will be a valuable resource to promote the prompt diagnosis of patients with this complex, multisystem, and often devastating disorder; enhance public understanding; and provide a firm foundation for future improvements in diagnosis and treatment.
