Stigma of mental illness is a destructive force, significantly impacting the lives of people struggling with mental health problems and serving as a significant barrier to treatment. Vast evidence of the disparaging impact of stigma is found in the related scientific literature, as is the support for its presence across all cultures. However, the literature also suggests that there are significant differences among cultures in the scope and severity of such negativist attitudes toward consumers of mental health services. Different cultural and ethnic groups vary in the scope of their adherence to such discriminatory views and their reasons for engaging in stigmatization. The current research explored the relationship between culture and stigma of mental illness in a sample of college students enrolled at University of Hartford. In total, 86 people participated in the project, representing four cultural groups: (a) African American, (b) Hispanic, (c) Asian, and (d) Caucasian. The results supported the initial hypothesis where stigmatizing attitudes towards consumers of mental health were found among the participants, albeit not as extensive as it reportedly is in general society. Even though stigmatizing attitudes were found among the participants, the overall perception of people with mental illness was fairly positive. The participants reported willingness to have fairly close relationships with such individuals and their desired social distance did not prove overly extensive. Regardless, negative attributes associated with mental illness were reported by the participants, particularly in regards to stability of some of the disorders, a person's ability to respond to treatment and their ability to recover from the given condition. Additionally, the belief that people should be coerced into treatment, even against the given person's will, was quite dominant among the participants. Furthermore, people struggling with some of the mental health conditions were viewed as personally responsible for their condition. Interestingly, people with mental illness were not deemed highly dangerous and participants reported being quite willing to help such individuals. Lastly, as expected, cultural differences were found in such perceptions of mental illness, most significantly between African American and Caucasian respondents. Specifically, the differences were found in levels of acculturation, endorsement of segregation of people of mental illness (through such means as inpatient involuntary hospitalization), stability of depression (belief that people with depression can respond to treatment and that they will recover from the illness), and feeling pity for people struggling with cancer.