The food system is responsible for some of society’s most pressing sustainability challenges. Diets are currently unsustainable in many countries as evidenced by the growing burden of malnutrition, degradation of natural resources, contributions to climate change, and unaffordability of healthy diets. There is an urgent need to address the gaps in understanding of what a sustainable food system means across varying populations and geographies and how we can better measure these systems, while identifying how dietary choices impact on human health and the environment. However, decision makers and experts are questioning whether it is possible to meet environmental, social, and economic goals simultaneously, or whether trade-offs are necessary. Thus, the development of better measurements and indicators to clearly understand the benefits and considerations for healthy and sustainable food systems is needed.