Amp Messenger
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| Author | : D. Hardie |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 313 |
| Release | : 2013-12-01 |
| Genre | : Science |
| ISBN | : 9401131082 |
The central theme of this book is that systems of cell-cell signalling via nerves, hormones, local mediators and growth factors are not distinct phenomena, but branches of one general mechanism. These topics therefore can and should be discussed in an integrated manner, and the division of cell signalling studies into separate pigeonholes such as neuroscience, endocrinology or cancer biology is unnecessary, if not counterproductive. I also believe it to be unfortunate that there is not a collective term to describe neurotransmitters, hormones, local mediators and growth factors, other than clumsy phrases such as "extracellular signal molecule". The lack of a short and distinctive word for these entities genuinely hampers people from thinking about them in an integrated way. Having decided that it was presumptuous to invent a new term, I have chosen in this book the term first messenger to cover all types of extracellular signal molecule, because of the widespread acceptance of the term second messenger to represent the intracellular signal molecules that are produced in response to many of them. I have given the book the title "biochemical messengers", which is a global term to cover both first and second messengers. The impetus for writing the book came, as must often be the case, when I had to put together a course on cell-cell signalling for biochemistry students at the University of Dundee.
| Author | : Terry P. Kenakin |
| Publisher | : Academic Press |
| Total Pages | : 260 |
| Release | : 2011-09-01 |
| Genre | : Medical |
| ISBN | : 0123848571 |
Pharmacology in Drug Discovery: Understanding Drug Response is designed for all students, recent graduates, and new researchers in the pharmaceutical and biotechnology industries who need to interpret change in physiology induced by a chemical substance. Physiological systems customize chemical signal input to their own needs; therefore the same drug can have different effects in different physiological systems. The field of pharmacology is unique in that it furnishes the tools to analyze these different behaviors and traces them to their root cause. This enables predictions of drug behavior to be made in all systems, an invaluable tool for drug discovery because almost all drugs are developed in test systems far removed from the therapeutic one. This valuable resource provides simple explanations of the ways in which biological systems use basic biochemical mechanisms to produce fine chemical control of physiology, allowing for more informed predictions of drug effects in all systems and forming the basis of the drug-discovery process. Chapters follow a logical progression on how to characterize the pharmacology of any given molecule, and include important terminology, chapter summaries, references, and review questions to aid the reader in understanding and retention of the material. - Enables the reader to interpret drug dose-response data and make mechanistic inferences at the molecular level - Bridges the gap between biochemistry and therapeutic medicine - Chapters include key topics such as drug affinity and efficacy, enzymes as drug targets, in vivo pharmacology, safety pharmacology, and more
| Author | : Sudha Vinayak Khanorkar |
| Publisher | : JP Medical Ltd |
| Total Pages | : 799 |
| Release | : 2011-12 |
| Genre | : Medical |
| ISBN | : 9350255162 |
| Author | : Shan-Ho Chou |
| Publisher | : Springer Nature |
| Total Pages | : 640 |
| Release | : 2020-03-05 |
| Genre | : Science |
| ISBN | : 3030333086 |
This book explores the broad and diverse biological and physiological impacts of established and newly discovered cyclic di-nucleotide second messenger signaling systems, while also providing descriptions of the intriguing biochemical characteristics of multiple turnover enzymes and receptors. The respective chapters discuss the commonalities and diversity of cyclic di-GMP, cyclic di-AMP and recently discovered cyclic GMP-AMP signaling systems in manifold Gram-negative and Gram-positive bacteria. The global human pathogens Mycobacterium tuberculosis, Vibrio cholerae, Salmonella typhimurium, Escherichia coli and Streptococcus pneumoniae, the facultative human pathogen Pseudomonas aeruginosa, global plant pathogens as exemplified by Xanthomonas campestris and Burkholderia spp., and the omnipresent probiotic Lactobacilli, as well as environmentally important photoautotrophic cyanobacteria, the multicellular Myxococcus xanthus, and chemolithotrophic Acidithiobacillus are among the representatives of the microbial kingdom that are described. In turn, the various aspects of bacterial physiology affected by these signaling systems– e.g. biofilm formation and dispersal, the cell cycle, motility, virulence, production of antimicrobials, fundamental metabolism and osmohomeostasis – are discussed in detail in the context of different microorganisms. Dedicated chapters focus on the population diversity of cyclic dinucleotide signaling systems, their tendency to be horizontally transferred, the cyclic di-GMP signaling system in the social amoeba Dictyostelium, honorary cyclic (di)nucleotides, and the development of strategies for interfering with cyclic dinucleotide signaling in order to manipulate microbial behavior. Taken together, the chapters provide an authoritative source of information for a broad readership: beginners and advanced researchers from various disciplines; individuals seeking a broad overview of cyclic di-nucleotide signaling; and those who want to learn more about specific aspects. Also featuring reviews with a forward-looking perspective, the book offers a valuable source of inspiration for future research directions.
| Author | : Valerie C. Scanlon |
| Publisher | : F.A. Davis |
| Total Pages | : 1454 |
| Release | : 2018-10-24 |
| Genre | : Medical |
| ISBN | : 0803694172 |
Tried and true - build A&P confidence every step of the way! Here’s the approach that makes A&P easier to master. A student-friendly writing style, superb art program, and learning opportunities in every chapter build a firm foundation in this must-know subject to ensure success. See what students are saying online… Great book!“This is THE best Anatomy & Physiology book I've ever used. Clear and easy to understand. Some of the areas of physiology I've had problems with in the past were made clear this term with this book! I had to have it for class of course, but I'd also read it for fun. (I plan to keep the book instead of sell it)”—A. Francis Good.“This was a great text for my Anatomy and Physiology class. It was easy to understand and I got a great grade.”—Alisa M. Also Available Student Workbook for Essentials of Anatomy and Physiology, 8th Edition
| Author | : Anthony K. Campbell |
| Publisher | : John Wiley & Sons |
| Total Pages | : 841 |
| Release | : 2014-10-16 |
| Genre | : Science |
| ISBN | : 1118675533 |
Thousands of imaginative scientists, over more than a century, have revealed the fascinating story of intracellular calcium, through a pathway of ingenious invention and discovery. Intracellular Calcium, the definitive book on this topic, reveals: The pathway of discovery and invention of intracellular calcium over more than 100 years. The evidence for intracellular calcium as a universal switch in all animal, plant, fungal and microbial cells How the components required for calcium signalling are named and classified. The ingenious technology, which has been developed to study intracellular calcium. How calcium is regulated inside cells and how it works to trigger an event. The role of intracellular calcium in disease, cell injury and cell death. How many drugs work through the calcium signalling system. How intracellular calcium is involved in the action of many natural toxins. How the intracellular calcium signalling system has evolved over 4000 million years, showing why it was crucial to the origin of life. A key principle presented throughout the book is the molecular variation upon which the intracellular calcium signalling system depends. This variation occurs within the same cell type and between cells with different functions, providing the invisible matrix upon which Darwin and Wallace’s Natural Selection depends. Featuring more than 100 figures, including detailed chemical structures as well as pictures of key pioneers in the field, a bibliography of more than 1500 references, as well as detailed subject and organism indices, this definitive work provides a unique source of scholarship for teachers and researchers in the biomedical sciences and beyond.
| Author | : C.M. Taylor |
| Publisher | : Newnes |
| Total Pages | : 508 |
| Release | : 2012-12-02 |
| Genre | : Science |
| ISBN | : 0080966942 |
This important new reference work offers an outstanding collection of articles devoted to the discussion of "intracellular messengers". Extracellular stimuli ("first messengers") bind to receptors on the plasma membrane of cells to trigger changes in the concentration of intracellular messengers ("second messengers") which leads, in turn, to changes in cellular activity. However, the intracellular activities of so called "third messengers" may also be involved complicating the concept of a rigid sequence of events between receptor and response. The preference for the term "intracellular messengers", and, hence, the title of this volume, recognizes that a complex web of interactions between intercellular messengers determines the concentrations and ultimate effects of each.
| Author | : Bryan H. Derrickson |
| Publisher | : John Wiley & Sons |
| Total Pages | : 914 |
| Release | : 2024-03-26 |
| Genre | : Science |
| ISBN | : 111982107X |
Human Physiology is known for its clear exposition, lifelike imagery, and dynamic animations, which provide students with intuitive instruction on the core principles of human physiology. The new edition offers updated research, case studies, enhanced illustrations, updated assessment, and careful attention to diversity, equity, and inclusion. Numerous real-world applications and activities keep students engaged and help them develop critical thinking and problem-solving skills. Human Physiology, 3rd edition offers students learning introductory physiology all the tools they need to succeed in the course and in their future careers.
| Author | : I. W. Jennings |
| Publisher | : Butterworth-Heinemann |
| Total Pages | : 161 |
| Release | : 2014-04-24 |
| Genre | : Medical |
| ISBN | : 1483192881 |
Vitamins in Endocrine Metabolism covers the problems of nutritional diseases in the fields of endocrinology, pathology, enzymology, and vitamin research. This book is divided into 11 chapters that discuss the conditions affecting vitamin requirements. The introductory chapters deal with the intracellular localization, synthesis, molecular structure, and reaction rate of enzymes. The succeeding chapters examine the methods of analysis and mode of action of hormones; pathology of vitamin A deficiency in man and animals; description of vitamin B complex; and diseases of vitamin C deficiency. Other chapters explore the modifying effects of the diet and availability of enzymic activators, as well as the biochemical aspects of isoenzymes, pre-enzymes, coenzymes, and enzyme cofactors. A chapter highlights the characteristics of vitamin, while another chapter is devoted to the chemical structure of vitamin E and the essential fatty acids. The final chapters focus on the exogenous chemical carcinogen. The book can provide useful information to doctors, nutritionists, students, and researchers.
| Author | : M Daniel |
| Publisher | : Routledge |
| Total Pages | : 636 |
| Release | : 2017-11-22 |
| Genre | : Science |
| ISBN | : 1351442155 |
Provides the latest information on nearly all of the phytoalexins of crop plants studied worldwide over the past 50 years-describing experimental approaches to the research of specific plants and offering detailed explanations on methods of isolation and characterization. Supplies in-depth coverage of cotton, soybean, groundnut, citrus, mustard, grapevine, potato, pepper, sweet potato, yam, sesame, tea, tobacco, pea, pigeon pea, and many more.
