Advances In Toxicity And Drug Testing
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| Author | : Judith Baker |
| Publisher | : |
| Total Pages | : 0 |
| Release | : 2015-01-17 |
| Genre | : Drugs |
| ISBN | : 9781632420374 |
This book discusses the latest advances and developments in toxicity and drug testing. It encompasses rising technologies (3D cultures, next generation sequencing, profiling technologies, etc.), available techniques and models to assess potential drugs and medicinal plants with reference to drug testing and advancement, and toxicity. Contributions have been made in this book by veterans from across the world. The aim of this book is to serve as a valuable source of information for physicians as well as scientists who are directly dealing with drugs/medicines and human life.
| Author | : Michael G. Bissell |
| Publisher | : Elsevier Health Sciences |
| Total Pages | : 216 |
| Release | : 2012-09-28 |
| Genre | : Medical |
| ISBN | : 1455747874 |
This issue of Clinics in Laboratory Medicine, titled Toxicology Testing, includes the following topics; Progress in Clinical Toxicology Testing, The Prescription Drug Abuse Epidemic, Substance Abuse Among Healthcare Professionals, Pain Management Drug Testing, Ethanol Biomarkers, Newly-emerging Drugs of Abuse, Synthetic Cannabinoids, Synthetic Cathenones, Immunoassay Methodology in Drugs-of-abuse Testing, Toxicology Testing in Alternative Specimen Matrices, Principles and Procedures in Postmortem Toxicology, and Pharmacogenetics and the Future of Toxicology Testing. Advances in toxicology testing are paving the way for major improvements in the way scientists evaluate health risks posed by toxic chemicals. Toxicity tests help scientists better understand how the human body carries out normal functions that are key to maintaining health. Therefore, this topic is important to the field of Laboratory Medicine.
| Author | : Uwe Marx |
| Publisher | : John Wiley & Sons |
| Total Pages | : 318 |
| Release | : 2007-02-27 |
| Genre | : Science |
| ISBN | : 3527609563 |
Here, expert scientists from industry and academia share their knowledge on the assembly of functional human tissues in vitro and how to design drug screenings predictive of human exposure. In so doing, they combine the latest technological developments with strategic outlooks, such as novel cell and tissue systems for drug screening and testing, as well as emerging in vitro culture technologies. Equally importantly, the book does not shy away from regulatory acceptance and ethical issues.
| Author | : Judith Baker |
| Publisher | : |
| Total Pages | : 0 |
| Release | : 2015-02-13 |
| Genre | : Drugs |
| ISBN | : 9781632423511 |
Present-day drug design and testing includes experimental in-vitro and in-vivo measurements of the drug candidate's adsorption, distribution, metabolism, elimination and toxicity (ADMET) properties in the initial stages of drug discovery. Just a poor percentage of the recommended drug candidates get the authorization of government and reach the market place. Disadvantageous pharmacokinetic properties, bad bioavailability and efficiency, negative side effects, poor solubility and toxicity matters are responsible for most of the drug failures confronted in the pharmaceutical industry. Authors from across the globe have provided information elucidating pharmaceutical concerns, regulatory policies and clinical properties in their respective countries hoping that the open trade of scientific ideas and outcomes compiled in this book will result in enhanced pharmaceutical products. This book has a section on drug design covering several research chapters.
| Author | : National Research Council |
| Publisher | : National Academies Press |
| Total Pages | : 217 |
| Release | : 2007-10-05 |
| Genre | : Nature |
| ISBN | : 0309109922 |
Advances in molecular biology and toxicology are paving the way for major improvements in the evaluation of the hazards posed by the large number of chemicals found at low levels in the environment. The National Research Council was asked by the U.S. Environmental Protection Agency to review the state of the science and create a far-reaching vision for the future of toxicity testing. The book finds that developing, improving, and validating new laboratory tools based on recent scientific advances could significantly improve our ability to understand the hazards and risks posed by chemicals. This new knowledge would lead to much more informed environmental regulations and dramatically reduce the need for animal testing because the new tests would be based on human cells and cell components. Substantial scientific efforts and resources will be required to leverage these new technologies to realize the vision, but the result will be a more efficient, informative and less costly system for assessing the hazards posed by industrial chemicals and pesticides.
| Author | : Sivakumar Joghi Thatha Gowder |
| Publisher | : BoD – Books on Demand |
| Total Pages | : 255 |
| Release | : 2013-01-23 |
| Genre | : Medical |
| ISBN | : 9535109464 |
This book "New Insights into Toxicity and Drug Testing" covers all emerging technologies (profiling technologies, 3D cultures, next generation sequencing etc.), available methods and models to evaluate candidate drugs and medicinal plants with reference to toxicity, drug testing and development. This book is an original contribution of experts from different parts of the globe and the in-depth information will be a significant resource for scientists and physicians who are directly dealing with drugs / medicines and human life.
| Author | : Frank A. Barile |
| Publisher | : CRC Press |
| Total Pages | : 338 |
| Release | : 2007-07-23 |
| Genre | : Medical |
| ISBN | : 1420008323 |
The evolution of toxicology testing finds its impetus in the continuing growth of the chemical and pharmaceutical industries, as well as the awareness of public health initiatives, needs, and responses that demand faster, more accurate, more economical methods for screening potential toxicity. Concurrent advances in biotechnology enable viable in v
| Author | : Ali S. Faqi |
| Publisher | : Academic Press |
| Total Pages | : 988 |
| Release | : 2016-11-03 |
| Genre | : Medical |
| ISBN | : 0128036214 |
A Comprehensive Guide to Toxicology in Nonclinical Drug Development, Second Edition, is a valuable reference designed to provide a complete understanding of all aspects of nonclinical toxicology in the development of small molecules and biologics. This updated edition has been reorganized and expanded to include important topics such as stem cells in nonclinical toxicology, inhalation and dermal toxicology, pitfalls in drug development, biomarkers in toxicology, and more. Thoroughly updated to reflect the latest scientific advances and with increased coverage of international regulatory guidelines, this second edition is an essential and practical resource for all toxicologists involved in nonclinical testing in industry, academic, and regulatory settings. Provides unique content that is not always covered together in one comprehensive resource, including chapters on stem cells, abuse liability, biomarkers, inhalation toxicology, biostatistics, and more Updated with the latest international guidelines for nonclinical toxicology in both small and large molecules Incorporates practical examples in order to illustrate day-to-day activities and the expectations associated with working in nonclinical toxicology
| Author | : Michael G. Bissell |
| Publisher | : Saunders |
| Total Pages | : 0 |
| Release | : 2012-09-18 |
| Genre | : Medical |
| ISBN | : 9781455749607 |
This issue of Clinics in Laboratory Medicine, titled Toxicology Testing, includes the following topics; Progress in Clinical Toxicology Testing, The Prescription Drug Abuse Epidemic, Substance Abuse Among Healthcare Professionals, Pain Management Drug Testing, Ethanol Biomarkers, Newly-emerging Drugs of Abuse, Synthetic Cannabinoids, Synthetic Cathenones, Immunoassay Methodology in Drugs-of-abuse Testing, Toxicology Testing in Alternative Specimen Matrices, Principles and Procedures in Postmortem Toxicology, and Pharmacogenetics and the Future of Toxicology Testing. Advances in toxicology testing are paving the way for major improvements in the way scientists evaluate health risks posed by toxic chemicals. Toxicity tests help scientists better understand how the human body carries out normal functions that are key to maintaining health. Therefore, this topic is important to the field of Laboratory Medicine.
| Author | : Keith Green |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 282 |
| Release | : 2012-12-06 |
| Genre | : Medical |
| ISBN | : 1461559375 |
This volume represents the proceedings of the Fifth Congress of the International Society of Ocular Toxicology (ISOT), which was held at the Grove Park Inn and Resort in Asheville, North Carolina, October 13-17, 1996. We are delighted to present this volume to the ophthalmic community, especially those with a significant interest in ocular toxicol ogy. The Fifth Congress was developed around themes relating to ocular drug metabolism, the ocular pathophysiological effects of nitric oxide, government issues relating to the use of alternative methods for toxicity testing, and a workshop that encompassed comparisons of both in vitro versus in vivo models as well as different animal models. The outcome of this congress, embodied in this volume, is a contribution to the methodologies currently employed or under development and to various drug or physical effects on different ocular tissues. While the focus of this proceedings is on ocular effects of drugs or other materials, many of the contributions deal with topics that have a much broader interest. The workshop concerning the use of different model systems and the choice of the best animal model for drug testing covers a wide range of interests that ex tends far beyond specific ocular effects. This is especially true in the area of alternative methods and in the choice of the best animal model for examination of different disease entities.
