Due to the importance for a range of sustainability challenges, it is important to understand the spatial dynamics of human settlements. The rapid expansion of built-up land is among the most extensive global land changes, even though built-up land occupies only a small fraction of the terrestrial biosphere. Moreover, the different ways in which human settlements are manifested are crucially important for their environmental and socioeconomic impacts. Yet, current analysis of human settlements heavily relies on land cover datasets, which typically have only one class to represent human settlements. Consequently, the analysis of human settlements does often not account for the heterogeneity within urban environment or their subtle changes. This simplistic representation severely limits our understanding of change processes in human settlements, as well as our capacity to assess socioeconomic and environmental impacts. This thesis aims to advance large-scale analysis of human settlements and their dynamics through the lens of land systems, with a specific focus on the role of land-use intensity. Chapter 2 explores the use of human settlement systems as an approach to understanding their variation in space and changes over time. Results show that settlement systems exist along a density gradient, and their change trajectories are typically gradual and incremental. In addition, results indicate that the total increase in built-up land in village landscapes outweighs that of dense urban regions. This chapter suggests that we should characterize human settlements more comprehensively to advance the analysis of human settlements, going beyond the emergence of new built-up land in a few mega-cities only. In Chapter 3, urban land-use intensity is operationalized by the horizontal and vertical spatial patterns of buildings.