Advances And Challenges In Nanomedicine
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| Author | : Susan Hua |
| Publisher | : Frontiers Media SA |
| Total Pages | : 155 |
| Release | : 2019-02-28 |
| Genre | : |
| ISBN | : 2889457451 |
Nanotechnology is a multidisciplinary field that is revolutionizing the way we detect and treat damage to the human body. Nanomedicine applies nanotechnology to highly specific medical interventions for the prevention, diagnosis, and treatment of diseases. They are increasingly being used to overcome biological barriers in the body to improve the way we deliver compounds to specific tissues and organs. In particular, nanomedicines have been shown to be beneficial for stabilizing therapeutic compounds, overcoming obstacles to cellular and tissue uptake, and improving biodistribution of compounds to target sites in vivo. Nanomedicines have demonstrated significant therapeutic advantages for a multitude of biomedical applications, however the clinical translation of these nanotechnology platforms has not progressed as quickly as the plethora of positive results would have suggested. Understanding the advances in nanomedicine to date and the challenges that still need to be overcome, will allow future research to improve on existing platforms and to address the current translational and regulatory limitations. This eBook “Advances and Challenges in Nanomedicine” has brought together experts in the fields of nanomedicine, nanotechnology, nanotoxicology, pharmaceutics, manufacturing, and translation to discuss the application of nanotechnology to drug delivery. This information is presented as original research, opinion, perspective, and review articles. The goal of this eBook is to generate collaborative discussion on the current status, general trends, challenges, strategies, and future direction of pharmaceutical nanotechnology, as well as highlight current and emerging nanoparticulate platforms with potential medical applications.
| Author | : Surendra Nimesh |
| Publisher | : Woodhead Publishing |
| Total Pages | : 258 |
| Release | : 2017-04-04 |
| Genre | : Medical |
| ISBN | : 0081005636 |
Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids addresses several issues related to safe and effective delivery of nucleic acids (NAs) using nanoparticles. A further emphasis would be laid on the mechanism of delivery of NAs, the barriers encountered and the strategies adapted to combat them. An exhaustive account of the advantages as well shortcomings of all the delivery vectors being employed in delivery of various NAs will be provided. On final note the regulatory aspects of nanoparticles mediated NA would be discussed, with focus on their clinical relevance. The design and development of nucleic acid-based therapeutics for the treatment of diseases arising from genetic abnormalities has made significant progress over the past few years. NAs have been widely explored for the treatment of cancer and infectious diseases or to block cell proliferation and thereby caused diseases. Advances in synthetic oligonucleotide chemistry resulted in synthesis of NAs that are relatively stable in in vivo environments. However, cellular targeting and intracellular delivery of NAs still remains a challenge. Further development of NA-based therapeutics depends on the progress of safe and effective carriers for systemic administration. Nanomedicine has facilitated availability of vectors with diminished cytotoxicity and enhanced efficacy which are rapidly emerging as systems of choice. These vectors protect NAs from enzymatic degradation by forming condensed complexes along with targeted tissue and cellular delivery. During the past few years, a myriad reports have appeared reporting delivery of NAs mediated by nanoparticles. This book will provide an overview of nanoparticles being employed in the in vitro and in vivo delivery of therapeutically relevant NAs like DNA, siRNA, LNA, PNA, etc. - Provides a complete overview of the applicatiosn of nanomedicine in the delivery of nucleic acids, from characterization of nanoparticles, to in vitro and in vivo studies - Discusses delivery issues of less well explored nucleic acids, like PNAs, Ribozymes, DNAzymes, etc. - Summarizes the current state of research in nucleic acid delivery and underscores the future of nanomedicine in this field
| Author | : Mehdi Razavi |
| Publisher | : Academic Press |
| Total Pages | : 319 |
| Release | : 2020-07-21 |
| Genre | : Science |
| ISBN | : 012820446X |
Neural Regenerative Nanomedicine presents novel, significant, experimental results relating to nanoscience and nanotechnology in neural regeneration. As current research is at the forefront of healing the nervous system, the content in the book focuses on basic, translational and clinical research in neural repair and regeneration. Chapters focus on stem cell biology to advance medical therapies for devastating disorders, the complex, delicate structures that make up the nervous system, and neurodegenerative diseases that cause progressive deterioration, including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis (ALS), multiple sclerosis and multiple system atrophy. - Presents a multidisciplinary focus on all research areas surrounding the applications of nanotechnology in neural regeneration - Provides a guide for physician and scientists, including necessary expertise for bioengineers, materials engineers, those in biomaterials and nanoengineering, stem cell biologists, and chemists - Covers many disciplines, including bioengineering, biomaterials, tissue engineering, regenerative medicine, neural regenerative medicine, and nanomedicine
| Author | : Vijay Mishra |
| Publisher | : Academic Press |
| Total Pages | : 553 |
| Release | : 2017-05-23 |
| Genre | : Medical |
| ISBN | : 0128097183 |
Nanotechnology-Based Approaches for Targeting and Delivery of Drugs and Genes provides an overview of the important aspects of nanomedicine in order to illustrate how to design and develop novel and effective drug delivery systems using nanotechnology. The book is organized into three sections, beginning with an introduction to nanomedicine and its associated issues. Section two discusses the latest technologies in nanomedicine, while the third section covers future developments and challenges in the field. By focusing on the design, synthesis, and application of a variety of nanocarriers in drug and gene delivery, this book provides pharmaceutical and materials science students, professors, clinical researchers, and industry scientists with a valuable resource aimed at tackling the challenges of delivering drugs and genes in a more targeted manner. - Explores a wide range of promising approaches for the diagnosis and treatment of diseases using the latest advances in cutting-edge nanomedical technologies - Contains contributions from world-renowned experts and researchers working in the area of nanomedicine and drug delivery - Covers the associated challenges and potential solutions to working with nanotechnology in drug delivery - Highlights crucial topics, such as biopharmaceutical and toxicity issues, quality by design, drug targeting, and more
| Author | : Rajaventhan Srirajaskanthan |
| Publisher | : CRC Press |
| Total Pages | : 462 |
| Release | : 2011-12-20 |
| Genre | : Medical |
| ISBN | : 1578087279 |
The nanosciences are a rapidly expanding field of research with a wide applicability to all areas of health. They encompass a variety of technologies ranging from particles to networks and nanostructures. This book focuses on the application of nanomedicine and nanotechnology to cancer. It introduces nanocarriers, nanorods, nanoprobes nanoplatforms, nanorings, nanotubes nanowires, nano-sensor arrays and a variety of methodological techniques. This is done within the framework of numerous cancer types. Contributors are all leading experts and are carrying out groundbreaking work. The book is essential reading for oncologists, research scientists, doctors, health care professionals, pathologists, biologists, biochemists, chemists and physicists as well as those interested in disease and nanosciences or cancer in general.
| Author | : Malay K. Das |
| Publisher | : Springer Nature |
| Total Pages | : 634 |
| Release | : 2020-12-09 |
| Genre | : Science |
| ISBN | : 9811562555 |
This book reviews the application of Nanobiotechnology in the development of Nanomedicine, while also discussing the latest trends and challenges in the clinical translation of Nanomedicine. Nanomedicine refers to the application of Nanotechnology to medicine and holds tremendous potential for achieving improved efficiency, bioavailability, dose response, personalized medicine and enhanced safety as compared to conventional medicines. The book first introduces readers to the basic concepts of Nanomedicine, and to technological advances in and applications of Nanotechnology in treatment, diagnosis, monitoring, and drug delivery. In turn, it reviews the current status of multi-functionalization strategies for using Nanoparticles in the targeted delivery of therapeutic agents. The book’s third and final section focuses on the regulatory and safety challenges posed by Nanomedicine, including industry and regulatory agencies’ efforts to address them.
| Author | : Pradipta Ranjan Rauta |
| Publisher | : CRC Press |
| Total Pages | : 293 |
| Release | : 2019-10-10 |
| Genre | : Medical |
| ISBN | : 0429521545 |
Nanotechnology in biology and medicine: Research advancements & future perspectives is focused to provide an interdisciplinary, integrative overview on the developments made in nanotechnology till date along with the ongoing trends and the future prospects. It presents the basics, fundamental results/current applications and latest achievements on nanobiotechnological researches worldwide scientific era. One of the major goals of this book is to highlight the multifaceted issues on or surrounding of nanotechnology on the basis of case studies, academic and theoretical articles, technology transfer (patents and copyrights), innovation, economics and policy management. Moreover, a large variety of nanobio-analytical methods are presented as a core asset to the early career researchers. This book has been designed for scientists, academician, students and entrepreneurs engaged in nanotechnology research and development. Nonetheless, it should be of interest to a variety of scientific disciplines including agriculture, medicine, drug and food material sciences and consumer products. Features It provides a thoroughly comprehensive overview of all major aspects of nanobiotechnology, considering the technology, applications, and socio-economic context It integrates physics, biology, and chemistry of nanosystems It reflects the state-of-the-art in nanotechnological research (biomedical, food, agriculture) It presents the application of nanotechnology in biomedical field including diagnostics and therapeutics (drug discovery, screening and delivery) It also discusses research involving gene therapy, cancer nanotheranostics, nano sensors, lab-on-a-chip techniques, etc. It provides the information about health risks of nanotechnology and potential remedies. It offers a timely forum for peer-reviewed research with extensive references within each chapter
| Author | : Daan J.A. Crommelin |
| Publisher | : Springer |
| Total Pages | : 390 |
| Release | : 2015-06-24 |
| Genre | : Medical |
| ISBN | : 3319162411 |
The rise of bio- and nano-technology in the last decades has led to the emergence of a new and unique type of medicine known as non-biological complex drugs (NBCDs). This book illustrates the challenges associated with NBCD development, as well as the complexity of assessing the effects of manufacturing changes on innovator and follow-on batches of NBCDs. It also touches upon proven marketing authorization requirements for biosimilars that could be effective in evaluating follow-on NBCDs, including a demonstration of control over the manufacturing process and a need for detailed physico-chemical characterization and (pre)clinical tests. This book is meant to be used for years to come as a standard reference work for the development of NBCDs. Moreover, this book aims to stimulate discussions and further our thinking to ensure that decisions regarding the approval of complex drugs are made with relevant scientific data on the table.
| Author | : Shaker A. Mousa |
| Publisher | : CRC Press |
| Total Pages | : 681 |
| Release | : 2020-01-17 |
| Genre | : Medical |
| ISBN | : 1000021270 |
The enormous advances in nanomedicine and precision medicine in the past two decades necessitated this comprehensive reference, which can be relied upon by researchers, clinicians, pharmaceutical scientists, regulators, policymakers, and lawyers alike. This standalone, full-color resource broadly surveys innovative technologies and advances pertaining to nanomedicine and precision medicine. In addition, it addresses often-neglected yet crucial areas such as translational medicine, intellectual property law, ethics, policy, FDA regulatory issues, nano-nomenclature, and artificial nano-machines—all accomplished in a user-friendly, broad yet interconnected format. The book is essential reading for the novice and the expert alike in diverse fields such as medicine, law, pharmacy, genomics, biomedical sciences, ethics, and regulatory science. The book’s multidisciplinary approach will attract a global audience and serve as a valuable reference resource for industry, academia, and government.
| Author | : Alexandru Mihai Grumezescu |
| Publisher | : William Andrew |
| Total Pages | : 581 |
| Release | : 2019-03-14 |
| Genre | : Science |
| ISBN | : 0128166290 |
Nanomaterials for Drug Delivery and Therapy presents recent advances in the field of nanobiomaterials and their important applications in drug delivery, therapy and engineering. The book offers pharmaceutical perspectives, exploring the development of nanobiomaterials and their interaction with the human body. Chapters show how nanomaterials are used in treatments, including neurology, dentistry and cancer therapy. Authored by a range of contributors from global institutions, this book offers a broad, international perspective on how nanotechnology-based advances are leading to novel drug delivery and treatment solutions. It is a valuable research resource that will help both practicing medics and researchers in pharmaceutical science and nanomedicine learn more on how nanotechnology is improving treatments. - Assesses the opportunities and challenges of nanotechnology-based drug delivery systems - Explores how nanotechnology is being used to create more efficient drug delivery systems - Discusses which nanomaterials make the best drug carriers
