Adult Neurogenesis
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| Author | : Juan J. Canales |
| Publisher | : Academic Press |
| Total Pages | : 300 |
| Release | : 2016-03-23 |
| Genre | : Medical |
| ISBN | : 0128019921 |
Neurogenesis in the adult brain has emerged as one of the most dynamic and rapidly moving fields in modern neuroscience research. The implications of adult neurogenesis for health and well-being are wide-ranging, with findings in this area having distinct relevance for treatment and rehabilitation in neurology and psychopathology. Adult Neurogenesis in the Hippocampus addresses these implications by providing an up-to-date account on how neurogenesis in the adult hippocampus contributes to critical psychological and physiological processes, such as learning and memory, and how it is modified by life experiences, such as aging, environmental enrichment, exercise, and dieting. The book also provides the most current reviews of how adult hippocampal neurogenesis influences the pathogenesis of mood disorders, addiction, and key neurological disorders. This book is the ideal resource for researchers and advanced graduates seeking focused knowledge on the role of adult neurogenesis in brain health and disease. - Provides a unique overview of how adult hippocampal neurogenesis contributes to adaptive processes, brain psychopathology, and disease - Includes state-of-the-art reviews by leading world experts in adult neurogenesis
| Author | : Tatsunori Seki |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 415 |
| Release | : 2011-06-15 |
| Genre | : Medical |
| ISBN | : 4431539336 |
The discovery of adult neurogenesis caused a paradigm shift in the neurosciences. For more than 100 years, it was believed that adult neurons do not regenerate. Joseph Altman and Fernando Nottebohm found proof to the contrary and changed the course of history. Their research, included here, provides the foundations of the field. Today, adult neurogenesis is a rapidly expanding discipline applicable to the study of brain development and diseases, learning and memory, aging, and neuropsychiatric disorders. With multiple authors, the 27 chapters of this book contain the latest work in two volumes. The first presents the basic biology of adult neurogenesis in non-mammalian vertebrates and in the mammalian hippocampus and olfactory bulb, and the second discusses clinical implications and delves into adult neurogenesis and brain injury as well as neurodegenerative and neuropsychiatric pathologies. With details of the anatomy, physiology, and molecular biology of the two neurogenic brain regions, this book provides indispensable knowledge for many areas of neuroscience and for experimental and clinical applications of adult neurogenesis to brain therapy.
| Author | : Arie S. Mobley |
| Publisher | : Academic Press |
| Total Pages | : 242 |
| Release | : 2019-03-05 |
| Genre | : Psychology |
| ISBN | : 0128110147 |
Neural Stem Cells and Adult Neurogenesis provides graduate students and neuroscientists with a basic understanding of what neural stem cells are and the cell types they produce. This early graduate level reference describes their physiology and potential for medicine and provides students with fundamental stem cell information. An overview of stem cell sources in the human body and a brief mention of relevant diseases provide context for the value of this knowledge. The book also includes chapters on induced pluripotent stem cells (iPSCs), the methods used to obtain them, and a review of the ethical challenges associated with stem cell research. For each region, the book provides a description of its neurogenic niche, cellular and molecular biology, and information on the neurons' contribution to normal and diseased brain function. The level of information is appropriate for early graduate students, introducing technology and molecular biology in an accessible format.
| Author | : Gerd Kempermann |
| Publisher | : Oxford University Press, USA |
| Total Pages | : 464 |
| Release | : 2006 |
| Genre | : Language Arts & Disciplines |
| ISBN | : 9780195179712 |
This is the first comprehensive, integrated account of one of the most exciting areas of neuroscience-the intersection between the discoveries that the adult brain makes new neurons and that it contains stem cells. The book begins with the historical background and discusses theories of adult neurogenesis and neural stem cell biology in the context of learning and memory processes as well as structural plasticity. It describes in detail neurogenesis in the adult hippocampus and olfactory system and then surveys the regulatory, functional, and comparative aspects, concluding with a chapter on the provocative hypotheses that link failing adult neurogenesis with such diseases as temporal lobe epilepsy, major depression, brain tumors, and dementias. This readable, single-authored volume is a unique resource for graduate students, investigators, and clinicians in the neurosciences, developmental biology, and stem cell research.
| Author | : Anna Menini |
| Publisher | : CRC Press |
| Total Pages | : 438 |
| Release | : 2009-11-24 |
| Genre | : Science |
| ISBN | : 1420071998 |
Comprehensive Overview of Advances in OlfactionThe common belief is that human smell perception is much reduced compared with other mammals, so that whatever abilities are uncovered and investigated in animal research would have little significance for humans. However, new evidence from a variety of sources indicates this traditional view is likely
| Author | : Carla Mucignat-Caretta |
| Publisher | : CRC Press |
| Total Pages | : 614 |
| Release | : 2014-02-14 |
| Genre | : Medical |
| ISBN | : 1466553413 |
Intraspecific communication involves the activation of chemoreceptors and subsequent activation of different central areas that coordinate the responses of the entire organism—ranging from behavioral modification to modulation of hormones release. Animals emit intraspecific chemical signals, often referred to as pheromones, to advertise their presence to members of the same species and to regulate interactions aimed at establishing and regulating social and reproductive bonds. In the last two decades, scientists have developed a greater understanding of the neural processing of these chemical signals. Neurobiology of Chemical Communication explores the role of the chemical senses in mediating intraspecific communication. Providing an up-to-date outline of the most recent advances in the field, it presents data from laboratory and wild species, ranging from invertebrates to vertebrates, from insects to humans. The book examines the structure, anatomy, electrophysiology, and molecular biology of pheromones. It discusses how chemical signals work on different mammalian and non-mammalian species and includes chapters on insects, Drosophila, honey bees, amphibians, mice, tigers, and cattle. It also explores the controversial topic of human pheromones. An essential reference for students and researchers in the field of pheromones, this is also an ideal resource for those working on behavioral phenotyping of animal models and persons interested in the biology/ecology of wild and domestic species.
| Author | : Catherine Belzung |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 447 |
| Release | : 2014-07-08 |
| Genre | : Medical |
| ISBN | : 364236232X |
This volume brings together authors working on a wide range of topics to provide an up to date account of the underlying mechanisms and functions of neurogenesis and synaptogenesis in the adult brain. With an increasing understanding of the role of neurogenesis and synaptogenesis it is possible to envisage improvements or novel treatments for a number of diseases and the possibility of harnessing these phenomena to reduce the impact of ageing and to provide mechanisms to repair the brain.
| Author | : Charles G. Gross |
| Publisher | : MIT Press |
| Total Pages | : 367 |
| Release | : 2012-01-13 |
| Genre | : Psychology |
| ISBN | : 0262291592 |
Essays on great figures and important issues, advances and blind alleys—from trepanation to the discovery of grandmother cells—in the history of brain sciences. Neuroscientist Charles Gross has been interested in the history of his field since his days as an undergraduate. A Hole in the Head is the second collection of essays in which he illuminates the study of the brain with fascinating episodes from the past. This volume's tales range from the history of trepanation (drilling a hole in the skull) to neurosurgery as painted by Hieronymus Bosch to the discovery that bats navigate using echolocation. The emphasis is on blind alleys and errors as well as triumphs and discoveries, with ancient practices connected to recent developments and controversies. Gross first reaches back into the beginnings of neuroscience, then takes up the interaction of art and neuroscience, exploring, among other things, Rembrandt's “Anatomy Lesson” paintings, and finally, examines discoveries by scientists whose work was scorned in their own time but proven correct in later eras.
| Author | : Arjen van Ooyen |
| Publisher | : Academic Press |
| Total Pages | : 586 |
| Release | : 2017-06-23 |
| Genre | : Science |
| ISBN | : 0128038721 |
The adult brain is not as hard-wired as traditionally thought. By modifying their small- or large-scale morphology, neurons can make new synaptic connections or break existing ones (structural plasticity). Structural changes accompany memory formation and learning, and are induced by neurogenesis, neurodegeneration and brain injury such as stroke. Exploring the role of structural plasticity in the brain can be greatly assisted by mathematical and computational models, as they enable us to bridge the gap between system-level dynamics and lower level cellular and molecular processes. However, most traditional neural network models have fixed neuronal morphologies and a static connectivity pattern, with plasticity merely arising from changes in the strength of existing synapses (synaptic plasticity). In The Rewiring Brain, the editors bring together for the first time contemporary modeling studies that investigate the implications of structural plasticity for brain function and pathology. Starting with an experimental background on structural plasticity in the adult brain, the book covers computational studies on homeostatic structural plasticity, the impact of structural plasticity on cognition and cortical connectivity, the interaction between synaptic and structural plasticity, neurogenesis-related structural plasticity, and structural plasticity in neurological disorders. Structural plasticity adds a whole new dimension to brain plasticity, and The Rewiring Brain shows how computational approaches may help to gain a better understanding of the full adaptive potential of the adult brain. The book is written for both computational and experimental neuroscientists. - Reviews the current state of knowledge of structural plasticity in the adult brain - Gives a comprehensive overview of computational studies on structural plasticity - Provides insights into the potential driving forces of structural plasticity and the functional implications of structural plasticity for learning and memory - Serves as inspiration for developing novel treatment strategies for stimulating functional repair after brain damage
| Author | : Ales Stuchlik |
| Publisher | : BoD – Books on Demand |
| Total Pages | : 180 |
| Release | : 2018-07-11 |
| Genre | : Medical |
| ISBN | : 1789233569 |
The hippocampus is an important brain region, a true central hub for memory of various kinds and other processes. Neuropsychiatric disorders such as Alzheimer's disease, drug addiction, and schizophrenia are characterized by hippocampal alterations. The dentate gyrus of the hippocampus is a site exhibiting adult neurogenesis. This book covers the topic of the hippocampus from various perspectives. It discusses adult neurogenesis, effect of enriched environments on hippocampal plasticity, and long-term potentiation-associated gene expression. The book also addresses multiscale representations of complex environments and strategies in the hippocampus-dependent spatial tasks. Finally, insight into the hippocampus as a link between negative affect and relapse to psychostimulants is provided. The book collects evidence of various hippocampal functions in healthy and disordered brain.
