Acute Toxicity Tests
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Author | : Shayne C. Gad |
Publisher | : Academic Press |
Total Pages | : 561 |
Release | : 1997-10-27 |
Genre | : Medical |
ISBN | : 008052592X |
Acute toxicology testing provides the first line of defense against potentially dangerous chemicals. This book is a complete and practical guide to conducting and interpreting all regulatory required and commonly used acute toxicity tests. It presents detailed protocols for all of the common test designs and reviews their development and objectives. Acute Toxicology Testing, Second Edition will interest not only workers in the pharmaceutical industry, but also researchers and students in toxicology and public health.Key Features* Over 100 tables summarizing and interpreting results* Complete coverage of all major test designs and their limitations and advantages* Current status of alternative test designs and models
Author | : Committee on Methods for Toxicity Tests with Aquatic Organisms |
Publisher | : |
Total Pages | : 82 |
Release | : 1975 |
Genre | : Aquatic animals |
ISBN | : |
Author | : |
Publisher | : DIANE Publishing |
Total Pages | : 275 |
Release | : 2002 |
Genre | : Water quality biological assessment |
ISBN | : 1428905375 |
Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 19 |
Release | : 2017-04-13 |
Genre | : |
ISBN | : 9264274758 |
Acute toxicity tests are an area of focus for developing alternative assays and approaches to address animal welfare concerns. In the context of this document, acute toxicity studies refer to studies involving a single exposure to a test chemical and include those assessing systemic toxicity as ...
Author | : Organisation for Economic Co-operation and Development |
Publisher | : Organisation for Economic Co-operation and Development ; [Montréal : Renouf] |
Total Pages | : |
Release | : 1981 |
Genre | : Chemical industry |
ISBN | : 9789264122215 |
Author | : W. Waynon Johnson |
Publisher | : |
Total Pages | : 106 |
Release | : 1980 |
Genre | : Acute toxicity testing |
ISBN | : |
Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 25 |
Release | : 2010-07-23 |
Genre | : |
ISBN | : 9264090894 |
This Test Guideline describes procedures designed to estimate the acute oral toxicity of substances to birds, and it provides three testing options: (1) limit dose test, (2) LD50-slope test, and (3) LD50-only test. The LD50-slope and LD50-only ...
Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 20 |
Release | : 2009-09-08 |
Genre | : |
ISBN | : 9264070605 |
This method provides information on health hazard likely to arise from short-term exposure to a test article (gas, vapour or aerosol/particulate test article) by inhalation. The revised Test Guideline describes two studies: a traditional LC50 ...
Author | : Ramesh C Gupta |
Publisher | : Academic Press |
Total Pages | : 1149 |
Release | : 2014-01-25 |
Genre | : Technology & Engineering |
ISBN | : 0124046495 |
Biomarkers in Toxicology is a timely and comprehensive reference dedicated to all aspects of biomarkers that relate to chemical exposure and their effects on biological systems. This book includes both vertebrate and non-vertebrate species models for toxicological testing and development of biomarkers. Divided into several key sections, this reference volume contains chapters devoted to topics in molecular-cellular toxicology, as well as a look at the latest cutting-edge technologies used to detect biomarkers of exposure and effects. Each chapter also contains several references to the current literature and important resources for further reading. Given this comprehensive treatment, Biomarkers in Toxicology is an essential reference for all those interested in biomarkers across several scientific and biomedical fields. - Written by international experts who have evaluated the expansive literature to provide you with one resource covering all aspects of toxicology biomarkers - Identifies and discusses the most sensitive, accurate, unique and validated biomarkers used as indicators of exposure and effect of chemicals of different classes - Covers special topics and applications of biomarkers, including chapters on molecular toxicology biomarkers, biomarker analysis for nanotoxicology, development of biomarkers for drug efficacy evaluation and much more
Author | : Frank A Barile |
Publisher | : CRC Press |
Total Pages | : 368 |
Release | : 2013-04-02 |
Genre | : Medical |
ISBN | : 1842145282 |
Nationally, toxicology programs have evolved from a traditional exploration of the chemistry and applied toxicity of chemicals and drugs to a more comprehensive study of toxicology and toxicology testing as independent entities. Consequently, the second edition of Principles of Toxicology Testing starts with basic toxicological principles, including absorption, distribution, metabolism, and elimination of toxins, including chemicals and drugs. The book then continues with animal (in vivo) and in vitro toxicology testing methods associated with toxicological analysis and preclinical drug development. As in the first edition, the book begins with an introduction into the fundamentals of toxicology (Section I) to prepare readers for the subsequent topics and continues through with a discussion of toxicokinetics and human risk assessment. This introductory material is useful in understanding the applications of toxicology testing. Section II describes the fundamental principles of toxicology testing in animals in greater detail. This section describes acute toxicity studies as well as subchronic and chronic studies performed on animals. Special emphasis is placed on study design and determination of classical indicators for acute and chronic testing, such as the LD50. The book examines other short- and long-term animal toxicity testing methodologies, including dermal, ocular, and reproductive toxicity testing. In addition, mutagenicity and carcinogenicity studies are also discussed in separate chapters. Section III introduces and discusses in vitro alternatives to animal toxicology tests. This section emphasizes cell culture methodology and cellular methods for acute systemic toxicity, target organ toxicity, and local toxicity. The contributors present the advantages and disadvantages of alternative methods. They also describe the use of high-throughput screening and its applications, the concepts of standardization and validation of in vitro techniques (especially large, organized validation efforts currently supported by US and EU regulatory agencies), and the theories supporting the development of in vitro methodologies. This second edition is a must-read for undergraduate and graduate toxicology students. Industrial and academic research centers will also find the text useful for establishing a toxicology testing laboratory.