Regulation of Bacterial Virulence

Regulation of Bacterial Virulence
Author: Michael L. Vasil
Publisher: American Society for Microbiology Press
Total Pages: 1189
Release: 2012-12-05
Genre: Science
ISBN: 1555816762

A comprehensive compendium of scholarly contributions relating to bacterial virulence gene regulation. • Provides insights into global control and the switch between distinct infectious states (e.g., acute vs. chronic). • Considers key issues about the mechanisms of gene regulation relating to: surface factors, exported toxins and export mechanisms. • Reflects on how the regulation of intracellular lifestyles and the response to stress can ultimately have an impact on the outcome of an infection. • Highlights and examines some emerging regulatory mechanisms of special significance. • Serves as an ideal compendium of valuable topics for students, researchers and faculty with interests in how the mechanisms of gene regulation ultimately affect the outcome of an array of bacterial infectious diseases.

Surgical Techniques in Rectal Cancer

Surgical Techniques in Rectal Cancer
Author: Giovanni Dapri
Publisher: Springer
Total Pages: 597
Release: 2018-02-09
Genre: Medical
ISBN: 443155579X

This book describes the various procedures, including surgery through the abdominal wall, through a transanal access or by the union of both, using an open, laparoscopic, or robotic approach. Worldwide pioneers for each technique are invited as authors and portray in step-by-step detail about each procedure. Of the 32 chapters, 23 are dedicated only for the surgical procedures. Each chapter is enriched by numerous figures, which complement the text, permitting the understanding of each surgical technique from its beginning until the last step. Eight additional chapters are dedicated to the clinical and anatomical aspects of rectal cancer. In the last decade there has been an impressive evolution in the treatment of patients with rectal cancer, with a focus not only on the preservation of a cancer-free life, but the quality of that life. This book has been written to be useful for everyone involved in rectal cancer management. From internists, gastroenterologists, endoscopists, oncologists, radiotherapists and radiologists involved in the treatment of rectal cancer during their daily practice, to surgeons specialized in colorectal surgery, to junior faculty to trainees, all interested in new and innovative techniques.

Diesel and Gasoline Engine Exhausts and Some Nitroarenes

Diesel and Gasoline Engine Exhausts and Some Nitroarenes
Author: IARC Working Group on the Evaluation of Carcinogenic Risks to Humans
Publisher: IARC Monographs on the Evaluat
Total Pages: 0
Release: 2015-06-04
Genre: Medical
ISBN: 9789283213284

This volume of the IARC Monographs provides evaluations of the carcinogenicity of diesel and gasoline engine exhausts, and of 10 nitroarenes found in diesel engine exhaust: 3,7-dinitrofluoranthene, 3,9-dinitrofluoranthene, 1,3-dinitropyrene, 1,6-dinitropyrene, 1,8-dinitropyrene, 6-nitrochrysene, 2-nitrofluorene, 1-nitropyrene, 4-nitropyrene, and 3-nitrobenzanthrone. Diesel engines are used for transport on and off roads (e.g. passenger cars, buses, trucks, trains, ships), for machinery in various industrial sectors (e.g. mining, construction), and for electricity generators, particularly in developing countries. Gasoline engines are used in cars and hand-held equipment (e.g. chainsaws). The emissions from such combustion engines comprise a complex and varying mixture of gases (e.g. carbon monoxide, nitrogen oxides), particles (e.g. PM10, PM2.5, ultrafine particles, elemental carbon, organic carbon, ash, sulfate, and metals), volatile organic compunds (e.g. benzene, formaldehyde) and semi-volatile organic compounds (e.g. polycyclic aromatic hydrocarbons) including oxygenated and nitrated derivatives of polycyclic aromatic hydrocarbons. Diesel and gasoline engines thus make a significant contribution to a broad range of air pollutants to which people are exposed in the general population as well as in different occupational settings. An IARC Monographs Working Group reviewed epidemiological evidence, animal bioassays, and mechanistic and other relevant data to reach conclusions as to the carcinogenic hazard to humans of environmental or occupational exposure to diesel and gasoline engine exhausts (including those associated with the mining, railroad, construction, and transportation industries) and to 10 selected nitroarenes. -- Back cover.

The Journal of the American Medical Association

The Journal of the American Medical Association
Author: American Medical Association
Publisher:
Total Pages: 1220
Release: 1907
Genre: American Medical Association
ISBN:

Includes proceedings of the Association, papers read at the annual sessions, and list of current medical literature.

Iron Physiology and Pathophysiology in Humans

Iron Physiology and Pathophysiology in Humans
Author: Gregory J. Anderson
Publisher: Springer Science & Business Media
Total Pages: 705
Release: 2012-01-14
Genre: Medical
ISBN: 1603274855

Iron Physiology and Pathophysiology in Humans provides health professionals in many areas of research and practice with the most up-to-date and well-referenced volume on the importance of iron as a nutrient and its role in health and disease. This important new volume is the benchmark in the complex area of interrelationships between the essentiality of iron, its functions throughout the body, including its critical role in erythropoiesis, the biochemistry and clinical relevance of iron-containing enzymes and other molecules involved in iron absorption, transport and metabolism, he importance of optimal iron status on immune function, and links between iron and the liver, heart, brain and other organs. Moreover, the interactions between genetic and environmental factors and the numerous co-morbidities seen with both iron deficiency and iron overload in at risk populations are clearly delineated so that students as well as practitioners can better understand the complexities of these interactions. Key features of the volume include an in-depth index and recommendations and practice guidelines are included in relevant chapters. The volume contains more than 100 detailed tables and informative figures and up-to-date references that provide the reader with excellent sources of information about the critical role of iron nutrition, optimal iron status and the adverse clinical consequences of altered iron homeostasis. Iron Physiology and Pathophysiology in Humans is an excellent new text as well as the most authoritative resource in the field.

Handbook of Sports Medicine and Science

Handbook of Sports Medicine and Science
Author: Ronald J. Maughan
Publisher: John Wiley & Sons
Total Pages: 201
Release: 2008-04-15
Genre: Medical
ISBN: 1405140550

Sports Nutrition, which focuses on the importance of proper nutritional preparation for athletes, provides a practical supplement to Nutrition in Sport. It provides an essential reference on all aspects of sports nutrition for the team coach, athletic trainer, physical therapist and allied health-related professional working with athletes and sports teams, and the knowledgeable athlete.

Introduction to EEG- and Speech-Based Emotion Recognition

Introduction to EEG- and Speech-Based Emotion Recognition
Author: Priyanka A. Abhang
Publisher: Academic Press
Total Pages: 200
Release: 2016-03-23
Genre: Medical
ISBN: 0128045310

Introduction to EEG- and Speech-Based Emotion Recognition Methods examines the background, methods, and utility of using electroencephalograms (EEGs) to detect and recognize different emotions. By incorporating these methods in brain-computer interface (BCI), we can achieve more natural, efficient communication between humans and computers. This book discusses how emotional states can be recognized in EEG images, and how this is useful for BCI applications. EEG and speech processing methods are explored, as are the technological basics of how to operate and record EEGs. Finally, the authors include information on EEG-based emotion recognition, classification, and a proposed EEG/speech fusion method for how to most accurately detect emotional states in EEG recordings. - Provides detailed insight on the science of emotion and the brain signals underlying this phenomenon - Examines emotions as a multimodal entity, utilizing a bimodal emotion recognition system of EEG and speech data - Details the implementation of techniques used for acquiring as well as analyzing EEG and speech signals for emotion recognition

Animal Toxins

Animal Toxins
Author: Hervé Rochat
Publisher: Springer Science & Business Media
Total Pages: 394
Release: 2000
Genre: Medical
ISBN: 9783764359836

Natural toxins form a major component of the molecular tools used increasingly frequently by the ever growing number of laboratories of various kinds. Evidence for this is provided not only by the increasing number of firms including such toxins in their catalogues but also by the large number of demands received by those who discover new toxins. Twenty chapters survey important aspects of toxin origin, their structure and molecular mechanism, and their cellular and pathogenic effects. In addition, the text provides comprehensive and specific methodology for the application of these toxins in the research laboratory. This begins with the description of the method of extraction, biochemical and pharmacological characterization, and assessment of purity, and continues with methods for chemical modification, e.g. labelling, and eventually describes applications in pharmacological studies in vivo and/or in vitro. The length of this book has been kept reasonable by concentrating on...

Current Trends in Monoclonal Antibody Development and Manufacturing

Current Trends in Monoclonal Antibody Development and Manufacturing
Author: Steven J. Shire
Publisher: Springer Science & Business Media
Total Pages: 348
Release: 2009-11-11
Genre: Medical
ISBN: 038776643X

Monoclonal antibodies represent one of the fastest growing areas of new drug development within the pharmaceutical industry. Several blockbuster products have been approved over the past several years including Rituxan, Remicade, Avastin, Humira, and Herceptin. In addition, over 300 new drugs are currently in clinical trials. With both large, established biotechnology companies and small start-ups involved in the development of this important class of molecules, monoclonal antibodies products will become increasingly prevalent over the next decade. Recently the regulatory review of monoclonal antibodies has been moved from Center for Biologics and Research to the Center for Drug Evaluation and Research (CDER) division of the US Food and Drug Administration. It is anticipated that CDER will expect a certain minimal amount of data to be provided as more of these products move through the regulatory pipeline. Current Trends in Monoclonal Antibody Development and Manufacturing will provide readers with an understanding of what is currently being done in the industry to develop, manufacture, and release monoclonal antibody products and what will be required for a successful regulatory submission.