This book collects papers presented at the Virtual International Conference on Soft Computing, Optimization Theory and Applications (SCOTA 2021), held at the Birla Institute of Technology, Mesra, Ranchi, India, from 26–27 March 2021. Topics discussed in the book are on fuzzy logic, neural networks and optimization algorithms, as well as their hybrid combinations, and their application in areas such as intelligent control and robotics, pattern recognition, medical diagnosis, time series prediction and optimization of complex problems. The book highlights research on: (a) hybrid intelligent systems based on soft computing, new concepts and algorithms based on fuzzy logic and their applications, (b) theory and practice of meta-heuristics in different areas of application, (c) applications of fuzzy logic, (d) neural networks and hybrid intelligent systems in medical applications, (e) neural networks and optimization and evolutionary algorithms and their different applications and (f) applications of fuzzy logic, neural networks and meta-heuristics in pattern recognition problems. Some papers contain applications background like approximate solution of fractional differential equations via fixed-point algorithms and applications to equilibrium problems and image deburring problems. The book will be of great use to students, researchers and scientists in computer science, optimization and engineering, and those interested on computational intelligence and soft computing and their applications.