Acculturative stress, perceived racial discrimination, family cohesion, familism, and ethnic racial identity are sociocultural factors that have often been associated with depressive symptoms in Latinx populations. Higher levels of acculturative stress and perceived racial discrimination are related to higher levels of depressive symptoms; higher levels of family cohesion, familism, and ethnic racial identity, as it related to belonging, are related to lower psychological distress. However, research has mainly examined these relationships cross-sectionally, therefore, little is known about the development of such relationships over time. Such findings are crucial in understanding the context of cultural background in psychopathology, and its influence on future psychological adjustment from the transition from youth to emerging adulthood. Therefore the primary purpose of the current study was to examine (1) the influence of acculturative stress perceived racial discrimination, family cohesion, familism, and ethnic racial identity on depressive symptoms at four various time points (2 youth, 2 emerging adult); (2) potential moderating variables (i.e., family cohesion, familism, ethnic racial identity) that may buffer or mitigate the impact of migration/minority stressors (i.e., acculturative stress, discrimination) on depressive symptoms; and (3) potential influences of the developmental trajectory of depression among a longitudinal Latinx subsample (N=2,631) (following cases from youth to emerging adulthood) from the Drug Use and Cultural Factors Among Hispanic Adolescents and Emerging Adults, Los Angeles, 2006-2016 dataset (Unger, 2016). Bivariate correlations revealed significant associations between acculturative stress, perceived racial discrimination, and family cohesion on depressive symptoms. No significant associations were found between familism and ethnic racial identity. However, for exploratory purposes, hypothesized models were untransformed, therefore, including all variables of interest, when possible. Findings revealed ethnic racial identity to be a significant moderator in the relationship between acculturative stress and depressive symptoms. Depressive symptoms consistently predicted paths to subsequent depression. Lastly perceived racial discrimination, acculturative stress, and family cohesion influenced the developmental trajectories of depression at the baseline level and rate of change, such that higher levels of perceived racial discrimination and acculturative stress and lower levels of family cohesion were associated with higher levels of depressive symptoms. Future research should explore differences based on gender as well as U.S. and non-U.S. born samples as these two control variables showed to be significantly related to outcome of interest. The current study and future studies on this topic can further expand our current understanding on the developmental impact that migration/minority stressors, cultural background and familial context have on psychopathology to better inform the creation of culturally responsive prevention and intervention efforts aimed at promoting positive psychosocial adjustment in at-risk, ethnic-minority youth.